The Semmelweis Study: a longitudinal occupational cohort study within the framework of the Semmelweis Caring University Model Program for supporting healthy aging

Zoltan Ungvari; Adam G. Tabák; Roza Adany; György Purebl; Csilla Kaposvári; Vince Fazekas-Pongor; Tamás Csípő; Zsófia Szarvas; Krisztián Horváth; Peter Mukli; Piroska Balog; Robert Bodizs; Peter Ujma; Adrienne Stauder; Daniel W. Belsky; Illés Kovács; Andriy Yabluchanskiy; Andrea B. Maier; Mariann Moizs; Piroska Östlin; Yongjie Yon; Péter Varga; Zoltán Vokó; Magor Papp; István Takács; Barna Vásárhelyi; Péter Torzsa; Péter Ferdinandy; Anna Csiszar; Zoltán Benyó; Attila J. Szabó; Gabriella Dörnyei; Mika Kivimäki; Miklos Kellermayer; Bela Merkely

doi:10.1007/s11357-023-01018-7

The Semmelweis Study: a longitudinal occupational cohort study within the framework of the Semmelweis Caring University Model Program for supporting healthy aging

Zoltan Ungvari^*, Adam G. Tabák, Roza Adany^*, György Purebl, Csilla Kaposvári, Vince Fazekas-Pongor, Tamás Csípő, Zsófia Szarvas, Krisztián Horváth, Peter Mukli, Piroska Balog, Robert Bodizs, Peter Ujma, Adrienne Stauder, Daniel W. Belsky, Illés Kovács, Andriy Yabluchanskiy, Andrea B. Maier, Mariann Moizs, Piroska ÖstlinYongjie Yon, Péter Varga, Zoltán Vokó, Magor Papp, István Takács, Barna Vásárhelyi, Péter Torzsa, Péter Ferdinandy, Anna Csiszar, Zoltán Benyó, Attila J. Szabó, Gabriella Dörnyei, Mika Kivimäki, Miklos Kellermayer, Bela Merkely

^*Corresponding author for this work

Research output: Contribution to Journal › Review article › Academic › peer-review

Abstract

The Semmelweis Study is a prospective occupational cohort study that seeks to enroll all employees of Semmelweis University (Budapest, Hungary) aged 25 years and older, with a population of 8866 people, 70.5% of whom are women. The study builds on the successful experiences of the Whitehall II study and aims to investigate the complex relationships between lifestyle, environmental, and occupational risk factors, and the development and progression of chronic age-associated diseases. An important goal of the Semmelweis Study is to identify groups of people who are aging unsuccessfully and therefore have an increased risk of developing age-associated diseases. To achieve this, the study takes a multidisciplinary approach, collecting economic, social, psychological, cognitive, health, and biological data. The Semmelweis Study comprises a baseline data collection with open healthcare data linkage, followed by repeated data collection waves every 5 years. Data are collected through computer-assisted self-completed questionnaires, followed by a physical health examination, physiological measurements, and the assessment of biomarkers. This article provides a comprehensive overview of the Semmelweis Study, including its origin, context, objectives, design, relevance, and expected contributions.

Original language	English
Pages (from-to)	191-218
Number of pages	28
Journal	GeroScience
Volume	46
Issue number	1
Early online date	7 Dec 2023
DOIs	https://doi.org/10.1007/s11357-023-01018-7
Publication status	Published - Feb 2024

Bibliographical note

Publisher Copyright:
© 2023, The Author(s).

Funding

Funding for the initial infrastructure and the baseline data collection of the study has been provided by a series of grants obtained from the Ministry of Innovation and Technology of Hungary, the National Research, Development and Innovation Fund, the European University for Well-Being (EUniWell) program, and by the leadership of Semmelweis University through the allocation of resources for the purposes of the study. Once the cohort is assembled, continuing support will be sought from Semmelweis University and national and international funding organizations. The leadership team of the Semmelweis Study will apply for research funding from a variety of sponsors, including the National Research, Development and Innovation Fund, the Hungarian Academy of Sciences, the European Research Council, and private foundations. The goal is to secure funding to allow for an increasingly rich data collection in the upcoming phases through personal contact with the cohort participants. Open access funding provided by Semmelweis University. Project no. TKP2021-NKTA-47 has been implemented with the support provided by the Ministry of Innovation and Technology of Hungary from the National Research, Development and Innovation Fund, financed under the TKP2021-NKTA funding scheme. Funding for the project through the National Cardiovascular Laboratory Program (RRF-2.3.1–21-2022–00003) was provided by the Ministry of Innovation and Technology of Hungary from the National Research, Development and Innovation Fund. Project no. 135784 has also been implemented with the support provided from the National Research, Development and Innovation Fund of Hungary, financed under the K_20 funding scheme. This work was also supported by grants from the National Research, Development and Innovation Office (RRF-2.3.1-NKL), the Hungarian Academy of Sciences (TK2016-78) and the European University for Well-Being (EUniWell) program (grant agreement number: 101004093/ EUniWell/EAC-A02-2019 / EAC-A02-2019–1). The project has received funding from the HUN-REN Hungarian Research Network (TKCS-2021/32). Dr Adam Tabák was supported by the UK Medical Research Council (S011676), NordForsk (the Nordic Research Programme on Health and Welfare, 75021). Dr. Daniel W. Belsky is a fellow of the CIFAR CBD Network. Dr Mika Kivimäki is supported by the Wellcome Trust (221854/Z/20/Z), the Medical Research Council (R024227, S011676), the National Institute on Aging (R01AG056477, R01AG062553), and Academy of Finland (350426). Drs. Anna Csiszar, Zoltan Ungvari, Peter Mukli and Andriy Yabluchanskiy were supported by the National Institute on Aging (RF1AG072295, R01AG055395, R01AG068295; R01AG070915, R03AG070479), the National Institute of Neurological Disorders and Stroke (R01NS100782), the National Cancer Institute (R01CA255840), the Oklahoma Shared Clinical and Translational Resources (U54GM104938) with an Institutional Development Award (IDeA) from NIGMS, the Presbyterian Health Foundation, the Reynolds Foundation, the Oklahoma Nathan Shock Center (P30AG050911), and the Cellular and Molecular GeroScience CoBRE (P20GM125528). The funding sources had no role in the study design; in the collection, analysis and interpretation of data; in the writing of the report; and in the decision to submit the article for publication.

Funders	Funder number
Presbyterian Health Foundation
National Institute of General Medical Sciences
Ministry of Innovation and Technology
Semmelweis Egyetem
Ministry of Innovation and Technology of Hungary
European Research Council
Richard S. Reynolds Foundation
Wellcome Trust	221854/Z/20/Z, 221854
Nemzeti Kutatási Fejlesztési és Innovációs Hivatal	RRF-2.3.1-NKL
National Institute of Neurological Disorders and Stroke	R01NS100782
NordForsk	75021
Medical Research Council	MR/S011676/1, R024227, S011676
National Cancer Institute	R01CA255840
Academy of Finland	R01AG070915, R01AG068295, R01AG055395, RF1AG072295, R03AG070479
Oklahoma Shared Clinical and Translational Resources	U54GM104938
National Cardiovascular Laboratory Program	RRF-2.3.1–21-2022–00003, 135784
European University for Well-Being	101004093/ EUniWell/EAC-A02-2019 / EAC-A02-2019–1
National Health and Medical Research Council	350426
HUN-REN Hungarian Research Network	TKCS-2021/32
Magyar Tudományos Akadémia	TK2016-78
Oklahoma Nathan Shock Center	P30AG050911
National Institute on Aging	R01AG062553, R01AG056477
Nemzeti Kutatási, Fejlesztési és Innovaciós Alap	TKP2021-NKTA-47
Cellular and Molecular GeroScience CoBRE	P20GM125528

Keywords

Age-associated diseases
Biological age
Central Europe
Epidemiology
Health Promoting University
Healthy aging
Workplace cohort

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Ungvari, Z., Tabák, A. G., Adany, R., Purebl, G., Kaposvári, C., Fazekas-Pongor, V., Csípő, T., Szarvas, Z., Horváth, K., Mukli, P., Balog, P., Bodizs, R., Ujma, P., Stauder, A., Belsky, D. W., Kovács, I., Yabluchanskiy, A., Maier, A. B., Moizs, M., ... Merkely, B. (2024). The Semmelweis Study: a longitudinal occupational cohort study within the framework of the Semmelweis Caring University Model Program for supporting healthy aging. GeroScience, 46(1), 191-218. https://doi.org/10.1007/s11357-023-01018-7

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abstract = "The Semmelweis Study is a prospective occupational cohort study that seeks to enroll all employees of Semmelweis University (Budapest, Hungary) aged 25 years and older, with a population of 8866 people, 70.5\% of whom are women. The study builds on the successful experiences of the Whitehall II study and aims to investigate the complex relationships between lifestyle, environmental, and occupational risk factors, and the development and progression of chronic age-associated diseases. An important goal of the Semmelweis Study is to identify groups of people who are aging unsuccessfully and therefore have an increased risk of developing age-associated diseases. To achieve this, the study takes a multidisciplinary approach, collecting economic, social, psychological, cognitive, health, and biological data. The Semmelweis Study comprises a baseline data collection with open healthcare data linkage, followed by repeated data collection waves every 5 years. Data are collected through computer-assisted self-completed questionnaires, followed by a physical health examination, physiological measurements, and the assessment of biomarkers. This article provides a comprehensive overview of the Semmelweis Study, including its origin, context, objectives, design, relevance, and expected contributions.",

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doi = "10.1007/s11357-023-01018-7",

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Ungvari, Z, Tabák, AG, Adany, R, Purebl, G, Kaposvári, C, Fazekas-Pongor, V, Csípő, T, Szarvas, Z, Horváth, K, Mukli, P, Balog, P, Bodizs, R, Ujma, P, Stauder, A, Belsky, DW, Kovács, I, Yabluchanskiy, A, Maier, AB, Moizs, M, Östlin, P, Yon, Y, Varga, P, Vokó, Z, Papp, M, Takács, I, Vásárhelyi, B, Torzsa, P, Ferdinandy, P, Csiszar, A, Benyó, Z, Szabó, AJ, Dörnyei, G, Kivimäki, M, Kellermayer, M & Merkely, B 2024, 'The Semmelweis Study: a longitudinal occupational cohort study within the framework of the Semmelweis Caring University Model Program for supporting healthy aging', GeroScience, vol. 46, no. 1, pp. 191-218. https://doi.org/10.1007/s11357-023-01018-7

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T1 - The Semmelweis Study: a longitudinal occupational cohort study within the framework of the Semmelweis Caring University Model Program for supporting healthy aging

AU - Ungvari, Zoltan

AU - Tabák, Adam G.

AU - Adany, Roza

AU - Purebl, György

AU - Kaposvári, Csilla

AU - Fazekas-Pongor, Vince

AU - Csípő, Tamás

AU - Szarvas, Zsófia

AU - Horváth, Krisztián

AU - Mukli, Peter

AU - Balog, Piroska

AU - Bodizs, Robert

AU - Ujma, Peter

AU - Stauder, Adrienne

AU - Belsky, Daniel W.

AU - Kovács, Illés

AU - Yabluchanskiy, Andriy

AU - Maier, Andrea B.

AU - Moizs, Mariann

AU - Östlin, Piroska

AU - Yon, Yongjie

AU - Varga, Péter

AU - Vokó, Zoltán

AU - Papp, Magor

AU - Takács, István

AU - Vásárhelyi, Barna

AU - Torzsa, Péter

AU - Ferdinandy, Péter

AU - Csiszar, Anna

AU - Benyó, Zoltán

AU - Szabó, Attila J.

AU - Dörnyei, Gabriella

AU - Kivimäki, Mika

AU - Kellermayer, Miklos

AU - Merkely, Bela

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N2 - The Semmelweis Study is a prospective occupational cohort study that seeks to enroll all employees of Semmelweis University (Budapest, Hungary) aged 25 years and older, with a population of 8866 people, 70.5% of whom are women. The study builds on the successful experiences of the Whitehall II study and aims to investigate the complex relationships between lifestyle, environmental, and occupational risk factors, and the development and progression of chronic age-associated diseases. An important goal of the Semmelweis Study is to identify groups of people who are aging unsuccessfully and therefore have an increased risk of developing age-associated diseases. To achieve this, the study takes a multidisciplinary approach, collecting economic, social, psychological, cognitive, health, and biological data. The Semmelweis Study comprises a baseline data collection with open healthcare data linkage, followed by repeated data collection waves every 5 years. Data are collected through computer-assisted self-completed questionnaires, followed by a physical health examination, physiological measurements, and the assessment of biomarkers. This article provides a comprehensive overview of the Semmelweis Study, including its origin, context, objectives, design, relevance, and expected contributions.

AB - The Semmelweis Study is a prospective occupational cohort study that seeks to enroll all employees of Semmelweis University (Budapest, Hungary) aged 25 years and older, with a population of 8866 people, 70.5% of whom are women. The study builds on the successful experiences of the Whitehall II study and aims to investigate the complex relationships between lifestyle, environmental, and occupational risk factors, and the development and progression of chronic age-associated diseases. An important goal of the Semmelweis Study is to identify groups of people who are aging unsuccessfully and therefore have an increased risk of developing age-associated diseases. To achieve this, the study takes a multidisciplinary approach, collecting economic, social, psychological, cognitive, health, and biological data. The Semmelweis Study comprises a baseline data collection with open healthcare data linkage, followed by repeated data collection waves every 5 years. Data are collected through computer-assisted self-completed questionnaires, followed by a physical health examination, physiological measurements, and the assessment of biomarkers. This article provides a comprehensive overview of the Semmelweis Study, including its origin, context, objectives, design, relevance, and expected contributions.

KW - Age-associated diseases

KW - Biological age

KW - Central Europe

KW - Epidemiology

KW - Health Promoting University

KW - Healthy aging

KW - Workplace cohort

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DO - 10.1007/s11357-023-01018-7

M3 - Review article

C2 - 38060158

SN - 2509-2715

VL - 46

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EP - 218

JO - GeroScience

JF - GeroScience

IS - 1

ER -

The Semmelweis Study: a longitudinal occupational cohort study within the framework of the Semmelweis Caring University Model Program for supporting healthy aging

Abstract

Bibliographical note

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Keywords

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