The sensitivity to change over time of the Amsterdam IADL Questionnaire(C)

N. Koster; D.L. Knol; B.M.J. Uitdehaag; P. Scheltens; S.A.M. Sikkes

doi:10.1016/j.jalz.2014.10.006

The sensitivity to change over time of the Amsterdam IADL Questionnaire(C)

N. Koster, D.L. Knol, B.M.J. Uitdehaag, P. Scheltens, S.A.M. Sikkes

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

Introduction This study aimed to investigate the sensitivity to change over time of a new informant-based instrument to assess instrumental activities of daily living (IADL) during the course of dementia: the Amsterdam IADL Questionnaire© (A-IADL-Q). Methods Participants (n = 102) were patients and their informants who visited the Alzheimer Center of the VU University Medical Center. Linear mixed models with random effects were used to relate longitudinal change on the A-IADL-Q to diagnosis and to longitudinal change in cognitive measures. Results We found longitudinal change on the A-IADL-Q to differ between diagnosis (P = .003), with dementia patients showing the fastest rate of decline (P < .001). In addition, we found longitudinal change on the A-IADL-Q to be related to longitudinal change in cognitive measures (global cognition: P < .001; memory: P = .024; executive functioning: P = .028). Discussion Findings indicate the A-IADL-Q is sensitive to change over time in IADL functioning and can be used in evaluating treatment effects and assessing individual disease progress.

Original language	English
Pages (from-to)	1231-1240
Journal	Alzheimers & Dementia
Volume	11
Issue number	10
DOIs	https://doi.org/10.1016/j.jalz.2014.10.006
Publication status	Published - 2015

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title = "The sensitivity to change over time of the Amsterdam IADL Questionnaire(C)",

abstract = "Introduction This study aimed to investigate the sensitivity to change over time of a new informant-based instrument to assess instrumental activities of daily living (IADL) during the course of dementia: the Amsterdam IADL Questionnaire{\textcopyright} (A-IADL-Q). Methods Participants (n = 102) were patients and their informants who visited the Alzheimer Center of the VU University Medical Center. Linear mixed models with random effects were used to relate longitudinal change on the A-IADL-Q to diagnosis and to longitudinal change in cognitive measures. Results We found longitudinal change on the A-IADL-Q to differ between diagnosis (P = .003), with dementia patients showing the fastest rate of decline (P < .001). In addition, we found longitudinal change on the A-IADL-Q to be related to longitudinal change in cognitive measures (global cognition: P < .001; memory: P = .024; executive functioning: P = .028). Discussion Findings indicate the A-IADL-Q is sensitive to change over time in IADL functioning and can be used in evaluating treatment effects and assessing individual disease progress.",

author = "N. Koster and D.L. Knol and B.M.J. Uitdehaag and P. Scheltens and S.A.M. Sikkes",

year = "2015",

doi = "10.1016/j.jalz.2014.10.006",

language = "English",

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pages = "1231--1240",

journal = "Alzheimers & Dementia",

issn = "1552-5260",

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TY - JOUR

T1 - The sensitivity to change over time of the Amsterdam IADL Questionnaire(C)

AU - Koster, N.

AU - Knol, D.L.

AU - Uitdehaag, B.M.J.

AU - Scheltens, P.

AU - Sikkes, S.A.M.

PY - 2015

Y1 - 2015

N2 - Introduction This study aimed to investigate the sensitivity to change over time of a new informant-based instrument to assess instrumental activities of daily living (IADL) during the course of dementia: the Amsterdam IADL Questionnaire© (A-IADL-Q). Methods Participants (n = 102) were patients and their informants who visited the Alzheimer Center of the VU University Medical Center. Linear mixed models with random effects were used to relate longitudinal change on the A-IADL-Q to diagnosis and to longitudinal change in cognitive measures. Results We found longitudinal change on the A-IADL-Q to differ between diagnosis (P = .003), with dementia patients showing the fastest rate of decline (P < .001). In addition, we found longitudinal change on the A-IADL-Q to be related to longitudinal change in cognitive measures (global cognition: P < .001; memory: P = .024; executive functioning: P = .028). Discussion Findings indicate the A-IADL-Q is sensitive to change over time in IADL functioning and can be used in evaluating treatment effects and assessing individual disease progress.

AB - Introduction This study aimed to investigate the sensitivity to change over time of a new informant-based instrument to assess instrumental activities of daily living (IADL) during the course of dementia: the Amsterdam IADL Questionnaire© (A-IADL-Q). Methods Participants (n = 102) were patients and their informants who visited the Alzheimer Center of the VU University Medical Center. Linear mixed models with random effects were used to relate longitudinal change on the A-IADL-Q to diagnosis and to longitudinal change in cognitive measures. Results We found longitudinal change on the A-IADL-Q to differ between diagnosis (P = .003), with dementia patients showing the fastest rate of decline (P < .001). In addition, we found longitudinal change on the A-IADL-Q to be related to longitudinal change in cognitive measures (global cognition: P < .001; memory: P = .024; executive functioning: P = .028). Discussion Findings indicate the A-IADL-Q is sensitive to change over time in IADL functioning and can be used in evaluating treatment effects and assessing individual disease progress.

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DO - 10.1016/j.jalz.2014.10.006

M3 - Article

SN - 1552-5260

VL - 11

SP - 1231

EP - 1240

JO - Alzheimers & Dementia

JF - Alzheimers & Dementia

IS - 10

ER -

The sensitivity to change over time of the Amsterdam IADL Questionnaire(C)

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