The seroprevalence of cytomegalovirus infection in Belgium anno 2002 and 2006: A comparative analysis with hepatitis a virus seroprevalence

G. S.A. Smit*, S. Abrams, P. Dorny, N. Speybroeck, B. Devleesschauwer, V. Hutse, H. Jansens, H. Theeten, P. Beutels, N. Hens

*Corresponding author for this work

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

Cytomegalovirus (CMV) infection is endemic worldwide but its seroprevalence varies widely. The goal of this study was to estimate the age-specific seroprevalence of CMV infection in Belgium based on two cross-sectional serological datasets from 2002 and 2006. The seroprevalence was estimated relying on diagnostic test results based on cut-off values pre-specified by the manufacturers of the tests as well as relying on mixture models applied to continuous pathogen-specific immunoglobulin G antibody titre concentrations. The age-specific seroprevalence of hepatitis A virus (HAV), based on three Belgian cross-sectional serological datasets from 1993, 2002 and 2006, was used as a comparator since individuals acquire lifelong immunity upon recovery, implying an increasing seroprevalence with age. The age group weighted overall CMV seroprevalence derived from the mixture model was 32% (95% confidence interval (CI) 31–34%) in 2002 and 31% (95% CI 30–32%) in 2006. We demonstrated that CMV epidemiology differs from the immunizing infection HAV. This was the first large-scale study of CMV and HAV serial datasets in Belgium, estimating seroprevalence specified by age and birth cohort.

Original languageEnglish
Article numbere154
JournalEpidemiology and Infection
Volume147
DOIs
Publication statusPublished - 1 Jan 2019
Externally publishedYes

Keywords

  • Cytomegalovirus
  • Estimating age and birth cohort-specific seroprevalence
  • Hepatitis A virus
  • Mixture modelling
  • Seroincidence

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