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The stability and change of wellbeing across the lifespan: A longitudinal twin-sibling study

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

Background Wellbeing is relatively stable over the life span. However, individuals differ in this stability and change. One explanation for these differences could be the influence of different genetic or environmental factors on wellbeing over time. Methods To investigate causes of stability and change of wellbeing across the lifespan, we used cohort-sequential data on wellbeing from twins and their siblings of the Netherlands Twin Register (NTR) (total N = 46.885, 56% females). We organized wellbeing data in multiple age groups, from childhood (age 5), to adolescence, up to old age (age 61+). Applying a longitudinal genetic simplex model, we investigated the phenotypic stability of wellbeing and continuity and change in genetic and environmental influences. Results Wellbeing peaked in childhood, decreased during adolescence, and stabilized during adulthood. In childhood and adolescence, around 40% of the individual differences was explained by genetic effects. The heritability decreased toward old adulthood (35-24%) and the contribution of unique environmental effects increased to 76%. Environmental innovation was found at every age, whereas genetic innovation was only observed during adolescence (10-18 years). In childhood and adulthood, the absence of genetic innovation indicates a stable underlying set of genes influencing wellbeing during these life phases. Conclusion These findings provide insights into the stability and change of wellbeing and the genetic and environmental influences across the lifespan. Genetic effects were mostly stable, except in adolescence, whereas the environmental innovation at every age suggests that changing environmental factors are a source of changes in individual differences in wellbeing over time.

Original languageEnglish
Pages (from-to)2572-2584
Number of pages13
JournalPsychological Medicine
Volume54
Issue number10
Early online date27 Mar 2024
DOIs
Publication statusPublished - Jul 2024

Bibliographical note

Publisher Copyright:
Copyright © The Author(s), 2024. Published by Cambridge University Press.

Funding

The authors would like to thank all participants, who provided data for this stud This work is supported by an ERC consolidation grant (WELL-BEING 771057 PI Bartels), NWO large investment grant (NTR: 480-15-001/674), ZonMW Addiction program (31160008), Spinozapremie (NWO/SPI 56-464-14192), Twin family database for behavior genomics studies (NWO 480-04-004), Genetics of Mental Illness (ERC Advanced, 230374), the Biobank-based integrative omics study (BIOS) funded by BBMRI-NL (NWO projects 184.021.007 and 184.033.111), Genetic and Family influences on Adolescent psychopathology and Wellness (NWO 463-06-001), A twin-sib study of adolescent wellness (NWO-VENI 451-04-034), Determinants Of Adolescent Exercise Behavior (NIH-1R01DK092127-01), and Developmental Study of Attention Problems in Young Twins (National Institute of Mental Health, grant No. RO1 MH58799-03). M. Bartels is funded by an NWO-VICI grant (VI.C.211.054) This work is supported by an ERC consolidation grant (WELL-BEING 771057 PI Bartels), NWO large investment grant (NTR: 480-15-001/674), ZonMW Addiction program (31160008), Spinozapremie (NWO/SPI 56-464-14192), Twin family database for behavior genomics studies (NWO 480–04-004), Genetics of Mental Illness (ERC Advanced, 230374), the Biobank-based integrative omics study (BIOS) funded by BBMRI-NL (NWO projects 184.021.007 and 184.033.111), Genetic and Family influences on Adolescent psychopathology and Wellness (NWO 463-06-001), A twin-sib study of adolescent wellness (NWO-VENI 451-04-034), Determinants Of Adolescent Exercise Behavior (NIH-1R01DK092127-01), and Developmental Study of Attention Problems in Young Twins (National Institute of Mental Health, grant No. RO1 MH58799-03). M. Bartels is funded by an NWO-VICI grant (VI.C.211.054)

FundersFunder number
Genetics of Mental Illness
European Commission
European Research Council
Developmental Study of Attention Problems in Young Twins
???publication-publication-funding-organisation-not-added???VI.C.211.054
Seventh Framework Programme230374
ZonMw31160008, NWO 480–04-004, NWO/SPI 56-464-14192
NWO480-15-001/674
Horizon 2020 Framework Programme771057
National Institute of Mental HealthRO1 MH58799-03
BBMRI-NL463-06-001, NWO-VENI 451-04-034, 184.033.111, NIH-1R01DK092127-01, 184.021.007

    Keywords

    • heritability
    • longitudinal genetic analysis
    • quality of life
    • simplex models
    • stability
    • wellbeing

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