Abstract
Background Wellbeing is relatively stable over the life span. However, individuals differ in this stability and change. One explanation for these differences could be the influence of different genetic or environmental factors on wellbeing over time. Methods To investigate causes of stability and change of wellbeing across the lifespan, we used cohort-sequential data on wellbeing from twins and their siblings of the Netherlands Twin Register (NTR) (total N = 46.885, 56% females). We organized wellbeing data in multiple age groups, from childhood (age 5), to adolescence, up to old age (age 61+). Applying a longitudinal genetic simplex model, we investigated the phenotypic stability of wellbeing and continuity and change in genetic and environmental influences. Results Wellbeing peaked in childhood, decreased during adolescence, and stabilized during adulthood. In childhood and adolescence, around 40% of the individual differences was explained by genetic effects. The heritability decreased toward old adulthood (35-24%) and the contribution of unique environmental effects increased to 76%. Environmental innovation was found at every age, whereas genetic innovation was only observed during adolescence (10-18 years). In childhood and adulthood, the absence of genetic innovation indicates a stable underlying set of genes influencing wellbeing during these life phases. Conclusion These findings provide insights into the stability and change of wellbeing and the genetic and environmental influences across the lifespan. Genetic effects were mostly stable, except in adolescence, whereas the environmental innovation at every age suggests that changing environmental factors are a source of changes in individual differences in wellbeing over time.
| Original language | English |
|---|---|
| Pages (from-to) | 2572-2584 |
| Number of pages | 13 |
| Journal | Psychological Medicine |
| Volume | 54 |
| Issue number | 10 |
| Early online date | 27 Mar 2024 |
| DOIs | |
| Publication status | Published - Jul 2024 |
Bibliographical note
Publisher Copyright:Copyright © The Author(s), 2024. Published by Cambridge University Press.
Funding
The authors would like to thank all participants, who provided data for this stud This work is supported by an ERC consolidation grant (WELL-BEING 771057 PI Bartels), NWO large investment grant (NTR: 480-15-001/674), ZonMW Addiction program (31160008), Spinozapremie (NWO/SPI 56-464-14192), Twin family database for behavior genomics studies (NWO 480-04-004), Genetics of Mental Illness (ERC Advanced, 230374), the Biobank-based integrative omics study (BIOS) funded by BBMRI-NL (NWO projects 184.021.007 and 184.033.111), Genetic and Family influences on Adolescent psychopathology and Wellness (NWO 463-06-001), A twin-sib study of adolescent wellness (NWO-VENI 451-04-034), Determinants Of Adolescent Exercise Behavior (NIH-1R01DK092127-01), and Developmental Study of Attention Problems in Young Twins (National Institute of Mental Health, grant No. RO1 MH58799-03). M. Bartels is funded by an NWO-VICI grant (VI.C.211.054) This work is supported by an ERC consolidation grant (WELL-BEING 771057 PI Bartels), NWO large investment grant (NTR: 480-15-001/674), ZonMW Addiction program (31160008), Spinozapremie (NWO/SPI 56-464-14192), Twin family database for behavior genomics studies (NWO 480–04-004), Genetics of Mental Illness (ERC Advanced, 230374), the Biobank-based integrative omics study (BIOS) funded by BBMRI-NL (NWO projects 184.021.007 and 184.033.111), Genetic and Family influences on Adolescent psychopathology and Wellness (NWO 463-06-001), A twin-sib study of adolescent wellness (NWO-VENI 451-04-034), Determinants Of Adolescent Exercise Behavior (NIH-1R01DK092127-01), and Developmental Study of Attention Problems in Young Twins (National Institute of Mental Health, grant No. RO1 MH58799-03). M. Bartels is funded by an NWO-VICI grant (VI.C.211.054)
| Funders | Funder number |
|---|---|
| Genetics of Mental Illness | |
| European Commission | |
| European Research Council | |
| Developmental Study of Attention Problems in Young Twins | |
| ???publication-publication-funding-organisation-not-added??? | VI.C.211.054 |
| Seventh Framework Programme | 230374 |
| ZonMw | 31160008, NWO 480–04-004, NWO/SPI 56-464-14192 |
| NWO | 480-15-001/674 |
| Horizon 2020 Framework Programme | 771057 |
| National Institute of Mental Health | RO1 MH58799-03 |
| BBMRI-NL | 463-06-001, NWO-VENI 451-04-034, 184.033.111, NIH-1R01DK092127-01, 184.021.007 |
Keywords
- heritability
- longitudinal genetic analysis
- quality of life
- simplex models
- stability
- wellbeing
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