The tale of a tail: The secret behind IGF-1R’s oncogenic power

C. Crudden; L. Girnita

doi:10.1126/scisignal.abc8254

The tale of a tail: The secret behind IGF-1R’s oncogenic power

C. Crudden, L. Girnita

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government WorksThe C-terminal tail of insulin-like growth factor 1 receptor (IGF-1R) has long been appreciated to drive much of this receptor’s oncogenic power. In this issue of Science Signaling, Rieger et al. have shown that Tyr1250 and Tyr1251 of IGF-1R are autophosphorylated in a cell adhesion–dependent manner, uncovering a previously unknown plasma membrane–Golgi trafficking route for IGF-1R in migratory cells, an integral part of the malignant phenotype.

Original language	English
Article number	eabb7887
Journal	Science Signaling
Volume	13
Issue number	632
DOIs	https://doi.org/10.1126/scisignal.abc8254
Publication status	Published - 19 May 2020
Externally published	Yes

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AB - Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government WorksThe C-terminal tail of insulin-like growth factor 1 receptor (IGF-1R) has long been appreciated to drive much of this receptor’s oncogenic power. In this issue of Science Signaling, Rieger et al. have shown that Tyr1250 and Tyr1251 of IGF-1R are autophosphorylated in a cell adhesion–dependent manner, uncovering a previously unknown plasma membrane–Golgi trafficking route for IGF-1R in migratory cells, an integral part of the malignant phenotype.

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The tale of a tail: The secret behind IGF-1R’s oncogenic power

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