The Young Netherlands Twin Register (YNTR): Longitudinal Twin and Family Studies in Over 70,000 Children

C.E.M. van Beijsterveldt, M.M. Groen-Blokhuis, S. Franic, J.J. Hudziak, D.J. Lamb, C. Huppertz, L.E.J. de Zeeuw, M.G. Nivard, N.M. Schutte, S.C. Swagerman, T.J. Glasner, M.J. van Fulpen, C.D. Brouwer, T.M. Stroet, D. Nowotny, E.A. Ehli, G.E. Davies, P. Scheet, J.F. Orlebeke, K.J. Kan & 6 others D.J.A. Smit, C.V. Dolan, C.M. Middeldorp, E.J.C. de Geus, M. Bartels, D.I. Boomsma

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

The Netherlands Twin Register (NTR) began in 1987 with data collection in twins and their families, including families with newborn twins and triplets. Twenty-five years later, the NTR has collected at least one survey for 70,784 children, born after 1985. For the majority of twins, longitudinal data collection has been done by age-specific surveys. Shortly after giving birth, mothers receive a first survey with items on pregnancy and birth. At age 2, a survey on growth and achievement of milestones is sent. At ages 3, 7, 9/10, and 12 parents and teachers receive a series of surveys that are targeted at the development of emotional and behavior problems. From age 14 years onward, adolescent twins and their siblings report on their behavior problems, health, and lifestyle. When the twins are 18 years and older, parents are also invited to take part in survey studies. In sub-groups of different ages, in-depth phenotyping was done for IQ, electroencephalography , MRI, growth, hormones, neuropsychological assessments, and cardiovascular measures. DNA and biological samples have also been collected and large numbers of twin pairs and parents have been genotyped for zygosity by either micro-satellites or sets of short nucleotide polymorphisms and repeat polymorphisms in candidate genes. Subject recruitment and data collection is still ongoing and the longitudinal database is growing. Data collection by record linkage in the Netherlands is beginning and we expect these combined longitudinal data to provide increased insights into the genetic etiology of development of mental and physical health in children and adolescents. Copyright © The Authors 2012.
Original languageEnglish
Pages (from-to)252-267
JournalTwin Research and Human Genetics
Volume16
Issue number1
Early online date28 Nov 2012
DOIs
Publication statusPublished - 2013

Fingerprint

Twin Studies
Netherlands
Parents
Parturition
Growth Hormone
Surveys and Questionnaires
Life Style
Siblings
Electroencephalography
Mental Health
Nucleotides
Age Groups
Mothers
Newborn Infant
Databases
Pregnancy
DNA
Health
Growth

Cite this

van Beijsterveldt, C.E.M. ; Groen-Blokhuis, M.M. ; Franic, S. ; Hudziak, J.J. ; Lamb, D.J. ; Huppertz, C. ; de Zeeuw, L.E.J. ; Nivard, M.G. ; Schutte, N.M. ; Swagerman, S.C. ; Glasner, T.J. ; van Fulpen, M.J. ; Brouwer, C.D. ; Stroet, T.M. ; Nowotny, D. ; Ehli, E.A. ; Davies, G.E. ; Scheet, P. ; Orlebeke, J.F. ; Kan, K.J. ; Smit, D.J.A. ; Dolan, C.V. ; Middeldorp, C.M. ; de Geus, E.J.C. ; Bartels, M. ; Boomsma, D.I. / The Young Netherlands Twin Register (YNTR): Longitudinal Twin and Family Studies in Over 70,000 Children. In: Twin Research and Human Genetics. 2013 ; Vol. 16, No. 1. pp. 252-267.
@article{3979ebeb333c451d81daef6d0770c322,
title = "The Young Netherlands Twin Register (YNTR): Longitudinal Twin and Family Studies in Over 70,000 Children",
abstract = "The Netherlands Twin Register (NTR) began in 1987 with data collection in twins and their families, including families with newborn twins and triplets. Twenty-five years later, the NTR has collected at least one survey for 70,784 children, born after 1985. For the majority of twins, longitudinal data collection has been done by age-specific surveys. Shortly after giving birth, mothers receive a first survey with items on pregnancy and birth. At age 2, a survey on growth and achievement of milestones is sent. At ages 3, 7, 9/10, and 12 parents and teachers receive a series of surveys that are targeted at the development of emotional and behavior problems. From age 14 years onward, adolescent twins and their siblings report on their behavior problems, health, and lifestyle. When the twins are 18 years and older, parents are also invited to take part in survey studies. In sub-groups of different ages, in-depth phenotyping was done for IQ, electroencephalography , MRI, growth, hormones, neuropsychological assessments, and cardiovascular measures. DNA and biological samples have also been collected and large numbers of twin pairs and parents have been genotyped for zygosity by either micro-satellites or sets of short nucleotide polymorphisms and repeat polymorphisms in candidate genes. Subject recruitment and data collection is still ongoing and the longitudinal database is growing. Data collection by record linkage in the Netherlands is beginning and we expect these combined longitudinal data to provide increased insights into the genetic etiology of development of mental and physical health in children and adolescents. Copyright {\circledC} The Authors 2012.",
author = "{van Beijsterveldt}, C.E.M. and M.M. Groen-Blokhuis and S. Franic and J.J. Hudziak and D.J. Lamb and C. Huppertz and {de Zeeuw}, L.E.J. and M.G. Nivard and N.M. Schutte and S.C. Swagerman and T.J. Glasner and {van Fulpen}, M.J. and C.D. Brouwer and T.M. Stroet and D. Nowotny and E.A. Ehli and G.E. Davies and P. Scheet and J.F. Orlebeke and K.J. Kan and D.J.A. Smit and C.V. Dolan and C.M. Middeldorp and {de Geus}, E.J.C. and M. Bartels and D.I. Boomsma",
year = "2013",
doi = "10.1017/thg.2012.118",
language = "English",
volume = "16",
pages = "252--267",
journal = "Twin Research and Human Genetics",
issn = "1832-4274",
publisher = "Australian Academic Press",
number = "1",

}

van Beijsterveldt, CEM, Groen-Blokhuis, MM, Franic, S, Hudziak, JJ, Lamb, DJ, Huppertz, C, de Zeeuw, LEJ, Nivard, MG, Schutte, NM, Swagerman, SC, Glasner, TJ, van Fulpen, MJ, Brouwer, CD, Stroet, TM, Nowotny, D, Ehli, EA, Davies, GE, Scheet, P, Orlebeke, JF, Kan, KJ, Smit, DJA, Dolan, CV, Middeldorp, CM, de Geus, EJC, Bartels, M & Boomsma, DI 2013, 'The Young Netherlands Twin Register (YNTR): Longitudinal Twin and Family Studies in Over 70,000 Children' Twin Research and Human Genetics, vol. 16, no. 1, pp. 252-267. https://doi.org/10.1017/thg.2012.118

The Young Netherlands Twin Register (YNTR): Longitudinal Twin and Family Studies in Over 70,000 Children. / van Beijsterveldt, C.E.M.; Groen-Blokhuis, M.M.; Franic, S.; Hudziak, J.J.; Lamb, D.J.; Huppertz, C.; de Zeeuw, L.E.J.; Nivard, M.G.; Schutte, N.M.; Swagerman, S.C.; Glasner, T.J.; van Fulpen, M.J.; Brouwer, C.D.; Stroet, T.M.; Nowotny, D.; Ehli, E.A.; Davies, G.E.; Scheet, P.; Orlebeke, J.F.; Kan, K.J.; Smit, D.J.A.; Dolan, C.V.; Middeldorp, C.M.; de Geus, E.J.C.; Bartels, M.; Boomsma, D.I.

In: Twin Research and Human Genetics, Vol. 16, No. 1, 2013, p. 252-267.

Research output: Contribution to JournalArticleAcademicpeer-review

TY - JOUR

T1 - The Young Netherlands Twin Register (YNTR): Longitudinal Twin and Family Studies in Over 70,000 Children

AU - van Beijsterveldt, C.E.M.

AU - Groen-Blokhuis, M.M.

AU - Franic, S.

AU - Hudziak, J.J.

AU - Lamb, D.J.

AU - Huppertz, C.

AU - de Zeeuw, L.E.J.

AU - Nivard, M.G.

AU - Schutte, N.M.

AU - Swagerman, S.C.

AU - Glasner, T.J.

AU - van Fulpen, M.J.

AU - Brouwer, C.D.

AU - Stroet, T.M.

AU - Nowotny, D.

AU - Ehli, E.A.

AU - Davies, G.E.

AU - Scheet, P.

AU - Orlebeke, J.F.

AU - Kan, K.J.

AU - Smit, D.J.A.

AU - Dolan, C.V.

AU - Middeldorp, C.M.

AU - de Geus, E.J.C.

AU - Bartels, M.

AU - Boomsma, D.I.

PY - 2013

Y1 - 2013

N2 - The Netherlands Twin Register (NTR) began in 1987 with data collection in twins and their families, including families with newborn twins and triplets. Twenty-five years later, the NTR has collected at least one survey for 70,784 children, born after 1985. For the majority of twins, longitudinal data collection has been done by age-specific surveys. Shortly after giving birth, mothers receive a first survey with items on pregnancy and birth. At age 2, a survey on growth and achievement of milestones is sent. At ages 3, 7, 9/10, and 12 parents and teachers receive a series of surveys that are targeted at the development of emotional and behavior problems. From age 14 years onward, adolescent twins and their siblings report on their behavior problems, health, and lifestyle. When the twins are 18 years and older, parents are also invited to take part in survey studies. In sub-groups of different ages, in-depth phenotyping was done for IQ, electroencephalography , MRI, growth, hormones, neuropsychological assessments, and cardiovascular measures. DNA and biological samples have also been collected and large numbers of twin pairs and parents have been genotyped for zygosity by either micro-satellites or sets of short nucleotide polymorphisms and repeat polymorphisms in candidate genes. Subject recruitment and data collection is still ongoing and the longitudinal database is growing. Data collection by record linkage in the Netherlands is beginning and we expect these combined longitudinal data to provide increased insights into the genetic etiology of development of mental and physical health in children and adolescents. Copyright © The Authors 2012.

AB - The Netherlands Twin Register (NTR) began in 1987 with data collection in twins and their families, including families with newborn twins and triplets. Twenty-five years later, the NTR has collected at least one survey for 70,784 children, born after 1985. For the majority of twins, longitudinal data collection has been done by age-specific surveys. Shortly after giving birth, mothers receive a first survey with items on pregnancy and birth. At age 2, a survey on growth and achievement of milestones is sent. At ages 3, 7, 9/10, and 12 parents and teachers receive a series of surveys that are targeted at the development of emotional and behavior problems. From age 14 years onward, adolescent twins and their siblings report on their behavior problems, health, and lifestyle. When the twins are 18 years and older, parents are also invited to take part in survey studies. In sub-groups of different ages, in-depth phenotyping was done for IQ, electroencephalography , MRI, growth, hormones, neuropsychological assessments, and cardiovascular measures. DNA and biological samples have also been collected and large numbers of twin pairs and parents have been genotyped for zygosity by either micro-satellites or sets of short nucleotide polymorphisms and repeat polymorphisms in candidate genes. Subject recruitment and data collection is still ongoing and the longitudinal database is growing. Data collection by record linkage in the Netherlands is beginning and we expect these combined longitudinal data to provide increased insights into the genetic etiology of development of mental and physical health in children and adolescents. Copyright © The Authors 2012.

U2 - 10.1017/thg.2012.118

DO - 10.1017/thg.2012.118

M3 - Article

VL - 16

SP - 252

EP - 267

JO - Twin Research and Human Genetics

JF - Twin Research and Human Genetics

SN - 1832-4274

IS - 1

ER -