Thinner Medial Temporal Cortex in Adolescents With Attention-Deficit/Hyperactivity Disorder and the Effects of Stimulants

L. Schweren, C.A. Hartman, D.J. Heslenfeld, D. van der Meer, B. Franke, J. Oosterlaan, J.K. Buitelaar, S.V. Farone, P.J. Hoekstra

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

Objective Attention-deficit/hyperactivity disorder (ADHD) has been associated with widespread changes in cortical thickness (CT). Findings have been inconsistent, however, possibly due to age differences between samples. Cortical changes have also been suggested to be reduced or to disappear with stimulant treatment. We investigated differences in CT between adolescents/young adults with and without ADHD in the largest ADHD sample to date, the NeuroIMAGE sample. Second, we investigated how such differences were related to age and stimulant treatment. Method Participants (participants with ADHD = 306; healthy controls = 184, 61% male, 8-28 years of age, mean age = 17 years) underwent structural magnetic resonance imaging. Participants and pharmacies provided detailed information regarding lifetime stimulant treatment, including cumulative intake and age of treatment initiation and cessation. Vertexwise statistics were performed in Freesurfer, modeling the main effect of diagnosis on CT and its interaction with age. Effects of stimulant treatment parameters on CT were modeled within the sample with ADHD. Results After correction for multiple comparisons, participants with ADHD showed decreased medial temporal CT in both left (p
Original languageEnglish
Pages (from-to)660-667
JournalJournal of the American Academy of Child and Adolescent Psychiatry
Volume54
DOIs
Publication statusPublished - 2015

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