Thiosulfonates as Emerging Reactants: Synthesis and Applications

P. Mampuys, C. R. McElroy, J. H. Clark, R. V.A. Orru, B. U.W. Maes*

*Corresponding author for this work

Research output: Contribution to JournalReview articleAcademicpeer-review


The synthetic strategies towards thiosulfonates (RSO2SR1) are comprehensively reviewed from their original discovery to recent advances. Incorporation of the green credentials of the synthetic procedures towards thiosulfonates allows one to judge the merits of the state of the art, beyond the typical yield of a product and availability of the reactants. As reactant for organic transformations, thiosulfonates are particularly interesting given their possibility to react with nucleophiles, electrophiles and radicals. This review aims to give researchers, not familiar with the field, a good understanding of the general applications of thiosulfonates, while not skipping the recent important advances. The related, but less explored, selenosulfonates (RSO2SeR1) are also covered. (Figure presented.).

Original languageEnglish
Pages (from-to)1-63
Number of pages63
JournalAdvanced Synthesis and Catalysis
Issue number1
Publication statusE-pub ahead of print - 14 Oct 2019


  • green chemistry
  • multicomponent reactions
  • sulfur
  • synthetic applications
  • thiosulfonates

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