Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies

C.E. Elks; J.R.B. Perry; P. Sulem; D.I. Chasman; N. Franceschini; C. He; K.L. Lunetta; J.A. Visser; E.M. Byrne; D.L. Cousminer; J.J. Hottenga; E.J.C. de Geus; N.G. Martin; L. Peltonen; G. Willemsen; D.I. Boomsma; C.M. van Duijn; S.A. Loos; GW Montgomery; P.M. Ridker; T.D. Spector; E.A. Streeten; K. Stefansson; U. Thorsteinsdottir; A.G. Uitterlinden; E. Widen; J.M. Murabito; K.K. Ong; A. Murray

doi:10.1038/ng.714

Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies

C.E. Elks, J.R.B. Perry, P. Sulem, D.I. Chasman, N. Franceschini, C. He, K.L. Lunetta, J.A. Visser, E.M. Byrne, D.L. Cousminer, J.J. Hottenga, E.J.C. de Geus, N.G. Martin, L. Peltonen, G. Willemsen, D.I. Boomsma, C.M. van Duijn, S.A. Loos, GW Montgomery, P.M. RidkerT.D. Spector, E.A. Streeten, K. Stefansson, U. Thorsteinsdottir, A.G. Uitterlinden, E. Widen, J.M. Murabito, K.K. Ong, A. Murray

Biological Psychology

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

To identify loci for age at menarche, we performed a meta-analysis of 32 genome-wide association studies in 87,802 women of European descent, with replication in up to 14,731 women. In addition to the known loci at LIN28B (P = 5.4 × 10 -60) and 9q31.2 (P = 2.2 × 10 -33), we identified 30 new menarche loci (all P < 5 × 10 -8) and found suggestive evidence for a further 10 loci (P < 1.9 × 10 -6). The new loci included four previously associated with body mass index (in or near FTO, SEC16B, TRA2B and TMEM18), three in or near other genes implicated in energy homeostasis (BSX, CRTC1 and MCHR2) and three in or near genes implicated in hormonal regulation (INHBA, PCSK2 and RXRG). Ingenuity and gene-set enrichment pathway analyses identified coenzyme A and fatty acid biosynthesis as biological processes related to menarche timing. © 2010 Nature America, Inc. All rights reserved.

Original language	English
Pages (from-to)	1077-1085
Journal	Nature Genetics
Volume	42
Issue number	12
DOIs	https://doi.org/10.1038/ng.714
Publication status	Published - 2010

Cohort Studies

Netherlands Twin Register (NTR)

Access to Document

10.1038/ng.714

http://www.tweelingenregister.org/nederlands/verslaggeving/NTR-publicaties_2010/Elks_NG_2010.pdf

Persistent URL (handle)

Persistent link

Cite this

Elks, C. E., Perry, J. R. B., Sulem, P., Chasman, D. I., Franceschini, N., He, C., Lunetta, K. L., Visser, J. A., Byrne, E. M., Cousminer, D. L., Hottenga, J. J., de Geus, E. J. C., Martin, N. G., Peltonen, L., Willemsen, G., Boomsma, D. I., van Duijn, C. M., Loos, S. A., Montgomery, GW., ... Murray, A. (2010). Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies. Nature Genetics, 42(12), 1077-1085. https://doi.org/10.1038/ng.714

@article{d2edc7209f3647048bc58867f496837a,

title = "Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies",

abstract = "To identify loci for age at menarche, we performed a meta-analysis of 32 genome-wide association studies in 87,802 women of European descent, with replication in up to 14,731 women. In addition to the known loci at LIN28B (P = 5.4 × 10 -60) and 9q31.2 (P = 2.2 × 10 -33), we identified 30 new menarche loci (all P < 5 × 10 -8) and found suggestive evidence for a further 10 loci (P < 1.9 × 10 -6). The new loci included four previously associated with body mass index (in or near FTO, SEC16B, TRA2B and TMEM18), three in or near other genes implicated in energy homeostasis (BSX, CRTC1 and MCHR2) and three in or near genes implicated in hormonal regulation (INHBA, PCSK2 and RXRG). Ingenuity and gene-set enrichment pathway analyses identified coenzyme A and fatty acid biosynthesis as biological processes related to menarche timing. {\textcopyright} 2010 Nature America, Inc. All rights reserved.",

author = "C.E. Elks and J.R.B. Perry and P. Sulem and D.I. Chasman and N. Franceschini and C. He and K.L. Lunetta and J.A. Visser and E.M. Byrne and D.L. Cousminer and J.J. Hottenga and {de Geus}, E.J.C. and N.G. Martin and L. Peltonen and G. Willemsen and D.I. Boomsma and {van Duijn}, C.M. and S.A. Loos and GW Montgomery and P.M. Ridker and T.D. Spector and E.A. Streeten and K. Stefansson and U. Thorsteinsdottir and A.G. Uitterlinden and E. Widen and J.M. Murabito and K.K. Ong and A. Murray",

year = "2010",

doi = "10.1038/ng.714",

language = "English",

volume = "42",

pages = "1077--1085",

journal = "Nature Genetics",

issn = "1061-4036",

publisher = "Nature Research",

number = "12",

}

Elks, CE, Perry, JRB, Sulem, P, Chasman, DI, Franceschini, N, He, C, Lunetta, KL, Visser, JA, Byrne, EM, Cousminer, DL, Hottenga, JJ , de Geus, EJC, Martin, NG, Peltonen, L, Willemsen, G, Boomsma, DI, van Duijn, CM, Loos, SA, Montgomery, GW, Ridker, PM, Spector, TD, Streeten, EA, Stefansson, K, Thorsteinsdottir, U, Uitterlinden, AG, Widen, E, Murabito, JM, Ong, KK & Murray, A 2010, 'Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies', Nature Genetics, vol. 42, no. 12, pp. 1077-1085. https://doi.org/10.1038/ng.714

TY - JOUR

T1 - Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies

AU - Elks, C.E.

AU - Perry, J.R.B.

AU - Sulem, P.

AU - Chasman, D.I.

AU - Franceschini, N.

AU - He, C.

AU - Lunetta, K.L.

AU - Visser, J.A.

AU - Byrne, E.M.

AU - Cousminer, D.L.

AU - Hottenga, J.J.

AU - de Geus, E.J.C.

AU - Martin, N.G.

AU - Peltonen, L.

AU - Willemsen, G.

AU - Boomsma, D.I.

AU - van Duijn, C.M.

AU - Loos, S.A.

AU - Montgomery, GW

AU - Ridker, P.M.

AU - Spector, T.D.

AU - Streeten, E.A.

AU - Stefansson, K.

AU - Thorsteinsdottir, U.

AU - Uitterlinden, A.G.

AU - Widen, E.

AU - Murabito, J.M.

AU - Ong, K.K.

AU - Murray, A.

PY - 2010

Y1 - 2010

N2 - To identify loci for age at menarche, we performed a meta-analysis of 32 genome-wide association studies in 87,802 women of European descent, with replication in up to 14,731 women. In addition to the known loci at LIN28B (P = 5.4 × 10 -60) and 9q31.2 (P = 2.2 × 10 -33), we identified 30 new menarche loci (all P < 5 × 10 -8) and found suggestive evidence for a further 10 loci (P < 1.9 × 10 -6). The new loci included four previously associated with body mass index (in or near FTO, SEC16B, TRA2B and TMEM18), three in or near other genes implicated in energy homeostasis (BSX, CRTC1 and MCHR2) and three in or near genes implicated in hormonal regulation (INHBA, PCSK2 and RXRG). Ingenuity and gene-set enrichment pathway analyses identified coenzyme A and fatty acid biosynthesis as biological processes related to menarche timing. © 2010 Nature America, Inc. All rights reserved.

AB - To identify loci for age at menarche, we performed a meta-analysis of 32 genome-wide association studies in 87,802 women of European descent, with replication in up to 14,731 women. In addition to the known loci at LIN28B (P = 5.4 × 10 -60) and 9q31.2 (P = 2.2 × 10 -33), we identified 30 new menarche loci (all P < 5 × 10 -8) and found suggestive evidence for a further 10 loci (P < 1.9 × 10 -6). The new loci included four previously associated with body mass index (in or near FTO, SEC16B, TRA2B and TMEM18), three in or near other genes implicated in energy homeostasis (BSX, CRTC1 and MCHR2) and three in or near genes implicated in hormonal regulation (INHBA, PCSK2 and RXRG). Ingenuity and gene-set enrichment pathway analyses identified coenzyme A and fatty acid biosynthesis as biological processes related to menarche timing. © 2010 Nature America, Inc. All rights reserved.

U2 - 10.1038/ng.714

DO - 10.1038/ng.714

M3 - Article

SN - 1061-4036

VL - 42

SP - 1077

EP - 1085

JO - Nature Genetics

JF - Nature Genetics

IS - 12

ER -

Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies

Abstract

Cohort Studies

Access to Document

Persistent URL (handle)

Fingerprint

Cite this