Thrombophilia Mediates Lowering Cardiovascular Risk Factors in Women with a History of Preeclampsia

M. van der Horst, M.M. van Weissenbruch, J.I.P. de Vries

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    Objective. Preeclampsia is associated with increased risk of cardiovascular disease. The aim of this pilot study was to assess whether the presence of thrombophilia results in a greater tendency to develop endothelial dysfunction and cardiovascular diseases. Methods. Ten women with thrombophilia were matched with 10 women without thrombophilia for a history of hypertensive disorders during pregnancy. Laboratory measurements: blood pressure, insulin sensitivity, and micro- and macrovascular function were determined. Results. Women with thrombophilia had significant lower total- and low-density cholesterol, were more insulin sensitive, and had better microvascular function. Conclusion. This study suggests that thrombophilia "mediates" in lowering of cardiovascular risk factors in women with a history of preeclampsia. © 2011 Informa Healthcare USA, Inc.
    Original languageEnglish
    Pages (from-to)421-432
    JournalHypertension in Pregnancy
    Issue number4
    Publication statusPublished - 2011

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