Thrombophilia Mediates Lowering Cardiovascular Risk Factors in Women with a History of Preeclampsia

M. van der Horst; M.M. van Weissenbruch; J.I.P. de Vries

doi:10.3109/10641955.2010.506230

Thrombophilia Mediates Lowering Cardiovascular Risk Factors in Women with a History of Preeclampsia

M. van der Horst, M.M. van Weissenbruch, J.I.P. de Vries

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

Objective. Preeclampsia is associated with increased risk of cardiovascular disease. The aim of this pilot study was to assess whether the presence of thrombophilia results in a greater tendency to develop endothelial dysfunction and cardiovascular diseases. Methods. Ten women with thrombophilia were matched with 10 women without thrombophilia for a history of hypertensive disorders during pregnancy. Laboratory measurements: blood pressure, insulin sensitivity, and micro- and macrovascular function were determined. Results. Women with thrombophilia had significant lower total- and low-density cholesterol, were more insulin sensitive, and had better microvascular function. Conclusion. This study suggests that thrombophilia "mediates" in lowering of cardiovascular risk factors in women with a history of preeclampsia. © 2011 Informa Healthcare USA, Inc.

Original language	English
Pages (from-to)	421-432
Journal	Hypertension in Pregnancy
Volume	30
Issue number	4
DOIs	https://doi.org/10.3109/10641955.2010.506230
Publication status	Published - 2011

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title = "Thrombophilia Mediates Lowering Cardiovascular Risk Factors in Women with a History of Preeclampsia",

abstract = "Objective. Preeclampsia is associated with increased risk of cardiovascular disease. The aim of this pilot study was to assess whether the presence of thrombophilia results in a greater tendency to develop endothelial dysfunction and cardiovascular diseases. Methods. Ten women with thrombophilia were matched with 10 women without thrombophilia for a history of hypertensive disorders during pregnancy. Laboratory measurements: blood pressure, insulin sensitivity, and micro- and macrovascular function were determined. Results. Women with thrombophilia had significant lower total- and low-density cholesterol, were more insulin sensitive, and had better microvascular function. Conclusion. This study suggests that thrombophilia {"}mediates{"} in lowering of cardiovascular risk factors in women with a history of preeclampsia. {\textcopyright} 2011 Informa Healthcare USA, Inc.",

author = "{van der Horst}, M. and {van Weissenbruch}, M.M. and {de Vries}, J.I.P.",

year = "2011",

doi = "10.3109/10641955.2010.506230",

language = "English",

volume = "30",

pages = "421--432",

journal = "Hypertension in Pregnancy",

issn = "1064-1955",

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T1 - Thrombophilia Mediates Lowering Cardiovascular Risk Factors in Women with a History of Preeclampsia

AU - van der Horst, M.

AU - van Weissenbruch, M.M.

AU - de Vries, J.I.P.

PY - 2011

Y1 - 2011

N2 - Objective. Preeclampsia is associated with increased risk of cardiovascular disease. The aim of this pilot study was to assess whether the presence of thrombophilia results in a greater tendency to develop endothelial dysfunction and cardiovascular diseases. Methods. Ten women with thrombophilia were matched with 10 women without thrombophilia for a history of hypertensive disorders during pregnancy. Laboratory measurements: blood pressure, insulin sensitivity, and micro- and macrovascular function were determined. Results. Women with thrombophilia had significant lower total- and low-density cholesterol, were more insulin sensitive, and had better microvascular function. Conclusion. This study suggests that thrombophilia "mediates" in lowering of cardiovascular risk factors in women with a history of preeclampsia. © 2011 Informa Healthcare USA, Inc.

AB - Objective. Preeclampsia is associated with increased risk of cardiovascular disease. The aim of this pilot study was to assess whether the presence of thrombophilia results in a greater tendency to develop endothelial dysfunction and cardiovascular diseases. Methods. Ten women with thrombophilia were matched with 10 women without thrombophilia for a history of hypertensive disorders during pregnancy. Laboratory measurements: blood pressure, insulin sensitivity, and micro- and macrovascular function were determined. Results. Women with thrombophilia had significant lower total- and low-density cholesterol, were more insulin sensitive, and had better microvascular function. Conclusion. This study suggests that thrombophilia "mediates" in lowering of cardiovascular risk factors in women with a history of preeclampsia. © 2011 Informa Healthcare USA, Inc.

U2 - 10.3109/10641955.2010.506230

DO - 10.3109/10641955.2010.506230

M3 - Article

SN - 1064-1955

VL - 30

SP - 421

EP - 432

JO - Hypertension in Pregnancy

JF - Hypertension in Pregnancy

IS - 4

ER -

Thrombophilia Mediates Lowering Cardiovascular Risk Factors in Women with a History of Preeclampsia

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