Thrombophilias and adverse pregnancy outcome - a confounded problem!

W.J. Kist, N.G. Janssen, J.J. Kalk, W.M. Hague, G.A. Dekker, J.I. de Vries

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It was the objective of this study to analyse the influence of confounders, such as ethnicity, severity of illness and method of testing, in articles concerning the still moot relationship of thrombophilias to adverse pregnancy outcome (APO). Relevant case-control studies were identified using Medline and EMBASE data-bases between 1966 and 2006. Search terms were recurrent fetal loss, intrauterine fetal death, preeclampsia, HELLP-syndrome, eclampsia, fetal growth restriction, abruptio placentae, combined with maternal thrombophilias. Data was extracted from the articles per subgroup of APO regardless of confounder. These subgroups were tested if they fulfilled the heterogeneity testing criterion (I
Original languageEnglish
Pages (from-to)77-85
Number of pages9
JournalThrombosis and Haemostasis
Issue number1
Publication statusPublished - 2008


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