Thyroid stimulating hormone levels in newborns and early life exposure to endocrine disrupting chemicals - analysis of three European mother-child cohorts

Marijke de Cock, Michiel R de Boer, Eva Govarts, Nina Iszatt, Lubica Palkovicova, Marja H Lamoree, Greet Schoeters, Merete Eggesbø, Tomas Trnovec, Juliette Legler, Margot van de Bor

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

BACKGROUND: Various studies report interactions between thyroid hormones and early life chemical exposure. Our objective was to analyse associations between markers of endocrine disrupting chemical exposure and thyroid function in newborns, determined in heel prick blood spots.

METHODS: Three European mother-child cohorts (FLEHSI - Belgium, HUMIS - Norway, and the PCB cohort - Slovakia. Total n=1784) were pooled for the purpose of this study. Data on Thyroid Stimulating Hormone (TSH) was obtained from national neonatal screening registries, and cord plasma and/or breast milk was collected to determine exposure to various chemicals. Multiple regression models were composed with exposure and cohort as fixed factors, and adjustments were made for a priori defined covariates.

RESULTS: Median TSH concentrations were 1.00, 1.10, and 2.76 mU/l, for the Belgian, Norwegian, and the Slovak cohort, respectively. For polychlorinated biphenyl (PCB)-153 and dichlorodiphenyldichloroethylene (p,p'-DDE), children in the third exposure quartiles had a 12 - 15% lower TSH at birth. Results remained unchanged after additional adjustment for birth weight and gestational weight gain. No effect on TSH was observed for the other compounds.

CONCLUSION: Early life exposure to PCB-153, and p,p'-DDE was associated with newborn TSH levels. Higher exposure levels were associated with 12-15% lower TSH levels.Pediatric Research (2017); doi:10.1038/pr.2017.50.

Original languageEnglish
Pages (from-to)429-437
Number of pages9
JournalPediatric Research
Volume82
Early online date13 Mar 2017
DOIs
Publication statusPublished - 7 Jun 2017

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Endocrine Disruptors
Thyrotropin
Mothers
Newborn Infant
Polychlorinated Biphenyls
Dichlorodiphenyl Dichloroethylene
Social Adjustment
Neonatal Screening
Slovakia
Heel
Belgium
Human Milk
Norway
Thyroid Hormones
Birth Weight
Weight Gain
Registries
Thyroid Gland
Parturition
Pediatrics

Keywords

  • Journal Article

Cite this

de Cock, Marijke ; de Boer, Michiel R ; Govarts, Eva ; Iszatt, Nina ; Palkovicova, Lubica ; Lamoree, Marja H ; Schoeters, Greet ; Eggesbø, Merete ; Trnovec, Tomas ; Legler, Juliette ; van de Bor, Margot. / Thyroid stimulating hormone levels in newborns and early life exposure to endocrine disrupting chemicals - analysis of three European mother-child cohorts. In: Pediatric Research. 2017 ; Vol. 82. pp. 429-437.
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Thyroid stimulating hormone levels in newborns and early life exposure to endocrine disrupting chemicals - analysis of three European mother-child cohorts. / de Cock, Marijke; de Boer, Michiel R; Govarts, Eva; Iszatt, Nina; Palkovicova, Lubica; Lamoree, Marja H; Schoeters, Greet; Eggesbø, Merete; Trnovec, Tomas; Legler, Juliette; van de Bor, Margot.

In: Pediatric Research, Vol. 82, 07.06.2017, p. 429-437.

Research output: Contribution to JournalArticleAcademicpeer-review

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T1 - Thyroid stimulating hormone levels in newborns and early life exposure to endocrine disrupting chemicals - analysis of three European mother-child cohorts

AU - de Cock, Marijke

AU - de Boer, Michiel R

AU - Govarts, Eva

AU - Iszatt, Nina

AU - Palkovicova, Lubica

AU - Lamoree, Marja H

AU - Schoeters, Greet

AU - Eggesbø, Merete

AU - Trnovec, Tomas

AU - Legler, Juliette

AU - van de Bor, Margot

PY - 2017/6/7

Y1 - 2017/6/7

N2 - BACKGROUND: Various studies report interactions between thyroid hormones and early life chemical exposure. Our objective was to analyse associations between markers of endocrine disrupting chemical exposure and thyroid function in newborns, determined in heel prick blood spots.METHODS: Three European mother-child cohorts (FLEHSI - Belgium, HUMIS - Norway, and the PCB cohort - Slovakia. Total n=1784) were pooled for the purpose of this study. Data on Thyroid Stimulating Hormone (TSH) was obtained from national neonatal screening registries, and cord plasma and/or breast milk was collected to determine exposure to various chemicals. Multiple regression models were composed with exposure and cohort as fixed factors, and adjustments were made for a priori defined covariates.RESULTS: Median TSH concentrations were 1.00, 1.10, and 2.76 mU/l, for the Belgian, Norwegian, and the Slovak cohort, respectively. For polychlorinated biphenyl (PCB)-153 and dichlorodiphenyldichloroethylene (p,p'-DDE), children in the third exposure quartiles had a 12 - 15% lower TSH at birth. Results remained unchanged after additional adjustment for birth weight and gestational weight gain. No effect on TSH was observed for the other compounds.CONCLUSION: Early life exposure to PCB-153, and p,p'-DDE was associated with newborn TSH levels. Higher exposure levels were associated with 12-15% lower TSH levels.Pediatric Research (2017); doi:10.1038/pr.2017.50.

AB - BACKGROUND: Various studies report interactions between thyroid hormones and early life chemical exposure. Our objective was to analyse associations between markers of endocrine disrupting chemical exposure and thyroid function in newborns, determined in heel prick blood spots.METHODS: Three European mother-child cohorts (FLEHSI - Belgium, HUMIS - Norway, and the PCB cohort - Slovakia. Total n=1784) were pooled for the purpose of this study. Data on Thyroid Stimulating Hormone (TSH) was obtained from national neonatal screening registries, and cord plasma and/or breast milk was collected to determine exposure to various chemicals. Multiple regression models were composed with exposure and cohort as fixed factors, and adjustments were made for a priori defined covariates.RESULTS: Median TSH concentrations were 1.00, 1.10, and 2.76 mU/l, for the Belgian, Norwegian, and the Slovak cohort, respectively. For polychlorinated biphenyl (PCB)-153 and dichlorodiphenyldichloroethylene (p,p'-DDE), children in the third exposure quartiles had a 12 - 15% lower TSH at birth. Results remained unchanged after additional adjustment for birth weight and gestational weight gain. No effect on TSH was observed for the other compounds.CONCLUSION: Early life exposure to PCB-153, and p,p'-DDE was associated with newborn TSH levels. Higher exposure levels were associated with 12-15% lower TSH levels.Pediatric Research (2017); doi:10.1038/pr.2017.50.

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DO - 10.1038/pr.2017.50

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VL - 82

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JO - Pediatric Research

JF - Pediatric Research

SN - 0031-3998

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