Time-dependent hierarchical regulation analysis: deciphering cellular adaptation

F.J. Bruggeman, J. de Haan, H.M. Hardin, J.G. Bouwman, S.L. Rossell Aragort, K. van Eunen, B.M. Bakker, H.V. Westerhoff

Research output: Contribution to JournalArticleAcademicpeer-review


Cells adapt to changes in their environment by the concerted action of many different regulatory mechanisms. Examples of such mechanisms are feedback inhibition by intermediates of metabolism, covalent modification of enzymes and changes in the abundance of mRNAs and proteins. These mechanisms act in parallel at different levels in the cellular hierarchy while regulating a single process. Existing hierarchical regulation analysis determines the relative importance of these mechanisms when the cell regulates a transition from one steady-state to another. Here, the analysis is extended to the regulation of time-dependent phenomena, for which two methods are introduced and illustrated with a kinetic model incorporating transcription and translation of metabolic enzymes. © The Institution of Engineering and Technology 2006.
Original languageEnglish
Pages (from-to)318-322
Number of pages5
JournalIEE Proceedings. Systems Biology
Issue number5
Publication statusPublished - Sept 2006
Event12th BTK Meeting: `Systems Biology: redefining BioThermoKinetics' -
Duration: 1 Jan 20061 Jan 2006


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