Timed performance weaknesses on computerized tasks in pediatric brain tumor survivors: A comparison with sibling controls

Marieke Anna de Ruiter, Martha Alexandra Grootenhuis, Rosa van Mourik, Heleen Maurice-Stam, Marinus Hermanus Maria Breteler, Corrie Gidding, Laura Rachel Beek, Bernd Granzen, Dannis Gilbert van Vuurden, Antoinette Yvonne Narda Schouten-van Meeteren, Jaap Oosterlaan

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

With more children surviving a brain tumor, insight into the late effects of the disease and treatment is of high importance. This study focused on profiling the neurocognitive functions that might be affected after treatment for a pediatric brain tumor, using a broad battery of computerized tests. Predictors that may influence neurocognitive functioning were also investigated. A total of 82 pediatric brain tumor survivors (PBTSs) aged 8–18 years (M = 13.85, SD = 3.15, 49% males) with parent-reported neurocognitive complaints were compared to a control group of 43 siblings (age M = 14.27, SD = 2.44, 40% males) using linear mixed models. Neurocognitive performance was assessed using measures of attention, processing speed, memory, executive functioning, visuomotor integration (VMI), and intelligence. Tumor type, treatment, tumor location, hydrocephalus, gender, age at diagnosis, and time since diagnosis were entered into regression analyzes as predictors for neurocognitive functioning. The PBTSs showed slower processing speeds and lower intelligence (range effect sizes.71–.82, p <.001), as well as deficits in executive attention, short-term memory, executive functioning, and VMI (range effect sizes.40–.57, p <.05). Older age at assessment was associated with better neurocognitive functioning (B =.450, p <.001) and younger age at diagnosis was associated with lower intelligence (B =.328, p <.05). Medical risk factors, e.g., hydrocephalus, did not show an association with neurocognitive functioning. Late effects in PBTSs include a broad range of neurocognitive deficits. The results suggest that even PBTSs that were traditionally viewed as low risk for neurocognitive problems (e.g., surgery only, no hydrocephalus) may suffer from decreased neurocognitive functioning.

Original languageEnglish
Pages (from-to)208-227
Number of pages20
JournalChild Neuropsychology
Volume23
Issue number2
DOIs
Publication statusPublished - 17 Feb 2017

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Brain Neoplasms
Survivors
Siblings
Pediatrics
Hydrocephalus
Intelligence
Short-Term Memory
Linear Models
Neoplasms
Therapeutics
Regression Analysis
Control Groups

Keywords

  • attention
  • brain tumor
  • Cancer
  • memory
  • speed

Cite this

de Ruiter, Marieke Anna ; Grootenhuis, Martha Alexandra ; van Mourik, Rosa ; Maurice-Stam, Heleen ; Breteler, Marinus Hermanus Maria ; Gidding, Corrie ; Beek, Laura Rachel ; Granzen, Bernd ; van Vuurden, Dannis Gilbert ; Schouten-van Meeteren, Antoinette Yvonne Narda ; Oosterlaan, Jaap. / Timed performance weaknesses on computerized tasks in pediatric brain tumor survivors : A comparison with sibling controls. In: Child Neuropsychology. 2017 ; Vol. 23, No. 2. pp. 208-227.
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abstract = "With more children surviving a brain tumor, insight into the late effects of the disease and treatment is of high importance. This study focused on profiling the neurocognitive functions that might be affected after treatment for a pediatric brain tumor, using a broad battery of computerized tests. Predictors that may influence neurocognitive functioning were also investigated. A total of 82 pediatric brain tumor survivors (PBTSs) aged 8–18 years (M = 13.85, SD = 3.15, 49{\%} males) with parent-reported neurocognitive complaints were compared to a control group of 43 siblings (age M = 14.27, SD = 2.44, 40{\%} males) using linear mixed models. Neurocognitive performance was assessed using measures of attention, processing speed, memory, executive functioning, visuomotor integration (VMI), and intelligence. Tumor type, treatment, tumor location, hydrocephalus, gender, age at diagnosis, and time since diagnosis were entered into regression analyzes as predictors for neurocognitive functioning. The PBTSs showed slower processing speeds and lower intelligence (range effect sizes.71–.82, p <.001), as well as deficits in executive attention, short-term memory, executive functioning, and VMI (range effect sizes.40–.57, p <.05). Older age at assessment was associated with better neurocognitive functioning (B =.450, p <.001) and younger age at diagnosis was associated with lower intelligence (B =.328, p <.05). Medical risk factors, e.g., hydrocephalus, did not show an association with neurocognitive functioning. Late effects in PBTSs include a broad range of neurocognitive deficits. The results suggest that even PBTSs that were traditionally viewed as low risk for neurocognitive problems (e.g., surgery only, no hydrocephalus) may suffer from decreased neurocognitive functioning.",
keywords = "attention, brain tumor, Cancer, memory, speed",
author = "{de Ruiter}, {Marieke Anna} and Grootenhuis, {Martha Alexandra} and {van Mourik}, Rosa and Heleen Maurice-Stam and Breteler, {Marinus Hermanus Maria} and Corrie Gidding and Beek, {Laura Rachel} and Bernd Granzen and {van Vuurden}, {Dannis Gilbert} and {Schouten-van Meeteren}, {Antoinette Yvonne Narda} and Jaap Oosterlaan",
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de Ruiter, MA, Grootenhuis, MA, van Mourik, R, Maurice-Stam, H, Breteler, MHM, Gidding, C, Beek, LR, Granzen, B, van Vuurden, DG, Schouten-van Meeteren, AYN & Oosterlaan, J 2017, 'Timed performance weaknesses on computerized tasks in pediatric brain tumor survivors: A comparison with sibling controls' Child Neuropsychology, vol. 23, no. 2, pp. 208-227. https://doi.org/10.1080/09297049.2015.1108395

Timed performance weaknesses on computerized tasks in pediatric brain tumor survivors : A comparison with sibling controls. / de Ruiter, Marieke Anna; Grootenhuis, Martha Alexandra; van Mourik, Rosa; Maurice-Stam, Heleen; Breteler, Marinus Hermanus Maria; Gidding, Corrie; Beek, Laura Rachel; Granzen, Bernd; van Vuurden, Dannis Gilbert; Schouten-van Meeteren, Antoinette Yvonne Narda; Oosterlaan, Jaap.

In: Child Neuropsychology, Vol. 23, No. 2, 17.02.2017, p. 208-227.

Research output: Contribution to JournalArticleAcademicpeer-review

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AU - Grootenhuis, Martha Alexandra

AU - van Mourik, Rosa

AU - Maurice-Stam, Heleen

AU - Breteler, Marinus Hermanus Maria

AU - Gidding, Corrie

AU - Beek, Laura Rachel

AU - Granzen, Bernd

AU - van Vuurden, Dannis Gilbert

AU - Schouten-van Meeteren, Antoinette Yvonne Narda

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