A flexible, convergent synthesis of Cyclotheonamide B (1b) was developed, starting from the constituent amino acids, using conventional benzyl-, t-butyl- and allyl-based protecting groups. By modification of the key intermediates, this approach allows the preparation of cyclotheonamide analogues. © 1995.
Bastiaans, H. M. M., van der Baan, J. L., & Ottenheijm, H. C. J. (1995). Total synthesis of Cyclotheonamide B, a facile route towards analogues. Tetrahedron Letters, 36(33), 5963-5966. https://doi.org/10.1016/0040-4039(95)01153-9