Tomosyn-2 is required for normal motor performance in mice and sustains neurotransmission at motor endplates.

C.J. Geerts; J.J. Plomp; B. Koopmans; M. Loos; EM van der Pijl; M.A. van der Valk; M. Verhage; A.J.A. Groffen

doi:10.1007/s00429-014-0766-0

Tomosyn-2 is required for normal motor performance in mice and sustains neurotransmission at motor endplates.

C.J. Geerts
, J.J. Plomp
, B. Koopmans
, M. Loos
, EM van der Pijl
, M.A. van der Valk
, M. Verhage
, A.J.A. Groffen

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

Tomosyn-1 (STXBP5) is a soluble NSF attachment protein receptor complex-binding protein that inhibits vesicle fusion, but the role of tomosyn-2 (STXBP5L) in the mammalian nervous system is still unclear. Here we generated tomosyn-2 null (Tom2

Original language	English
Pages (from-to)	1971-1982
Journal	Brain Structure and Function
Volume	220
Issue number	4
DOIs	https://doi.org/10.1007/s00429-014-0766-0
Publication status	Published - 2015

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10.1007/s00429-014-0766-0

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title = "Tomosyn-2 is required for normal motor performance in mice and sustains neurotransmission at motor endplates.",

abstract = "Tomosyn-1 (STXBP5) is a soluble NSF attachment protein receptor complex-binding protein that inhibits vesicle fusion, but the role of tomosyn-2 (STXBP5L) in the mammalian nervous system is still unclear. Here we generated tomosyn-2 null (Tom2",

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T1 - Tomosyn-2 is required for normal motor performance in mice and sustains neurotransmission at motor endplates.

AU - Geerts, C.J.

AU - Plomp, J.J.

AU - Koopmans, B.

AU - Loos, M.

AU - van der Pijl, EM

AU - van der Valk, M.A.

AU - Verhage, M.

AU - Groffen, A.J.A.

PY - 2015

Y1 - 2015

N2 - Tomosyn-1 (STXBP5) is a soluble NSF attachment protein receptor complex-binding protein that inhibits vesicle fusion, but the role of tomosyn-2 (STXBP5L) in the mammalian nervous system is still unclear. Here we generated tomosyn-2 null (Tom2

AB - Tomosyn-1 (STXBP5) is a soluble NSF attachment protein receptor complex-binding protein that inhibits vesicle fusion, but the role of tomosyn-2 (STXBP5L) in the mammalian nervous system is still unclear. Here we generated tomosyn-2 null (Tom2

U2 - 10.1007/s00429-014-0766-0

DO - 10.1007/s00429-014-0766-0

M3 - Article

SN - 1863-2653

VL - 220

SP - 1971

EP - 1982

JO - Brain Structure and Function

JF - Brain Structure and Function

IS - 4

ER -

Tomosyn-2 is required for normal motor performance in mice and sustains neurotransmission at motor endplates.

Abstract

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