Abstract
In this 30th anniversary issue review, we focus on the glucocorticoid modulation of limbic-prefrontocortical circuitry during stress-coping. This action of the stress hormone is mediated by mineralocorticoid receptors (MRs) and glucocorticoid receptors (GRs) that are co-expressed abundantly in these higher brain regions. Via both receptor types, the glucocorticoids demonstrate, in various contexts, rapid nongenomic and slower genomic actions that coordinate consecutive stages of information processing. MR-mediated action optimises stress-coping, whereas, in a complementary fashion, the memory storage of the selected coping strategy is promoted via GR. We highlight the involvement of adipose tissue in the allocation of energy resources to central regulation of stress reactions, point to still poorly understood neuronal ensembles in the prefrontal cortex that underlie cognitive flexibility critical for effective coping, and evaluate the role of cortisol as a pleiotropic regulator in vulnerability to, and treatment of, trauma-related psychiatric disorders.
Original language | English |
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Article number | e12675 |
Pages (from-to) | 1-16 |
Number of pages | 16 |
Journal | Journal of Neuroendocrinology |
Volume | 31 |
Issue number | 3 |
Early online date | 22 Dec 2018 |
DOIs | |
Publication status | Published - Mar 2019 |
Bibliographical note
30th Anniversary Special IssueFunding
Support provided for the present work by KNAW (ERdK), NWO (SFdK) and NIH R00 grant R00HL125805‐01 (ADdK) is gratefully acknowledged.
Funders | Funder number |
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ADdK | |
ERdK | |
National Institutes of Health | R00HL125805‐01 |
National Heart, Lung, and Blood Institute | R01HL145028 |
Koninklijke Nederlandse Akademie van Wetenschappen | |
Nederlandse Organisatie voor Wetenschappelijk Onderzoek |
Keywords
- adipose tissue
- brain
- cognitive flexibility
- glucocorticoid receptors
- limbic-prefrontocortical circuitry
- mineralocorticoid receptors
- PTSD