TY - JOUR
T1 - Topographic Maps of Visual Space in the Human Cerebellum
AU - van Es, Daniel M.
AU - van der Zwaag, Wietske
AU - Knapen, Tomas
PY - 2019/5/20
Y1 - 2019/5/20
N2 - The purported role of the cerebellum has shifted from one that is exclusively sensorimotor related to one that encompasses a wide range of cognitive and associative functions [1–5]. Within sensorimotor areas of the cerebellum, functional organization is characterized by ipsilateral representations of the body [6]. Yet, in the remaining cerebellar cognitive and associative networks, functional organization remains less well understood. Regions of cerebral cortex [7–9] and subcortex [10] important for visual perception and cognition are organized topographically: neural organization mirrors the retina. Recently, it was shown that known retinotopic areas in cerebral cortex are functionally connected to nodes in the cerebellum [2, 11, 12]. In fact, this revealed signals with visuospatial selectivity in the cerebellum [13]. Here, we analyzed the highly powered Human Connectome Project (HCP) retinotopy dataset [14] to create a comprehensive and detailed overview of visuospatial organization in the cerebellum. This revealed 5 ipsilateral topographic maps in 3 cerebellar clusters (oculomotor vermis [OMV]-lobule VIIb-lobule VIIIb), of which we quantified visual field coverage and topography. These quantifications dovetail with the known roles of these areas in eye movements (OMV) [5, 15], attention (OMV-VIIb) [5, 13], working memory (VIIb) [13], and the integration of visuomotor information with respect to effector movements (VIIIb) [5]. To aid future research on visual perception in the cerebellum, we provide an online atlas of the visuospatial maps in Montreal Neurological Institute (MNI) space. Our findings demonstrate that the cerebellum is abundant with visuospatial information and, moreover, that it is organized according to known retinotopic properties. van Es et al. find the cerebellum's responses to visual stimuli to be retinotopically organized and highly similar to visual responses in the cerebral visual system. They publish an atlas of 5 visually selective regions in 3 cerebellar clusters.
AB - The purported role of the cerebellum has shifted from one that is exclusively sensorimotor related to one that encompasses a wide range of cognitive and associative functions [1–5]. Within sensorimotor areas of the cerebellum, functional organization is characterized by ipsilateral representations of the body [6]. Yet, in the remaining cerebellar cognitive and associative networks, functional organization remains less well understood. Regions of cerebral cortex [7–9] and subcortex [10] important for visual perception and cognition are organized topographically: neural organization mirrors the retina. Recently, it was shown that known retinotopic areas in cerebral cortex are functionally connected to nodes in the cerebellum [2, 11, 12]. In fact, this revealed signals with visuospatial selectivity in the cerebellum [13]. Here, we analyzed the highly powered Human Connectome Project (HCP) retinotopy dataset [14] to create a comprehensive and detailed overview of visuospatial organization in the cerebellum. This revealed 5 ipsilateral topographic maps in 3 cerebellar clusters (oculomotor vermis [OMV]-lobule VIIb-lobule VIIIb), of which we quantified visual field coverage and topography. These quantifications dovetail with the known roles of these areas in eye movements (OMV) [5, 15], attention (OMV-VIIb) [5, 13], working memory (VIIb) [13], and the integration of visuomotor information with respect to effector movements (VIIIb) [5]. To aid future research on visual perception in the cerebellum, we provide an online atlas of the visuospatial maps in Montreal Neurological Institute (MNI) space. Our findings demonstrate that the cerebellum is abundant with visuospatial information and, moreover, that it is organized according to known retinotopic properties. van Es et al. find the cerebellum's responses to visual stimuli to be retinotopically organized and highly similar to visual responses in the cerebral visual system. They publish an atlas of 5 visually selective regions in 3 cerebellar clusters.
KW - cerebellum
KW - fMRI
KW - pRF
KW - receptive field
KW - retinotopy
KW - visual perception
UR - http://www.scopus.com/inward/record.url?scp=85065674917&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85065674917&partnerID=8YFLogxK
U2 - 10.1016/j.cub.2019.04.012
DO - 10.1016/j.cub.2019.04.012
M3 - Article
C2 - 31080082
AN - SCOPUS:85065674917
SN - 0960-9822
VL - 29
SP - 1689-1694.e3
JO - Current Biology
JF - Current Biology
IS - 10
ER -