Total Synthesis of Aspidosperma and Strychnos Alkaloids through Indole Dearomatization

Jordy M. Saya; Eelco Ruijter; Romano V.A. Orru

doi:10.1002/chem.201901130

Total Synthesis of Aspidosperma and Strychnos Alkaloids through Indole Dearomatization

Jordy M. Saya, Eelco Ruijter^*, Romano V.A. Orru

^*Corresponding author for this work

Research output: Contribution to Journal › Review article › Academic › peer-review

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Abstract

Monoterpenoid indole alkaloids are the major class of tryptamine-derived alkaloids found in nature. Together with their structural complexity, this has attracted great interest from synthetic organic chemists. In this Review, the syntheses of Aspidosperma and Strychnos alkaloids through dearomatization of indoles are discussed.

Original language	English
Pages (from-to)	8916-8935
Number of pages	20
Journal	Chemistry - A European Journal
Volume	25
Issue number	38
Early online date	17 Apr 2019
DOIs	https://doi.org/10.1002/chem.201901130
Publication status	Published - 5 Jul 2019

Keywords

alkaloids
biomimetic synthesis
dearomatization
indoles
natural product synthesis

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Total Synthesis of Aspidosperma and Strychnos Alkaloids through Indole DearomatizationFinal published version, 7.82 MBLicence: Article 25fa Dutch Copyright Act

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abstract = "Monoterpenoid indole alkaloids are the major class of tryptamine-derived alkaloids found in nature. Together with their structural complexity, this has attracted great interest from synthetic organic chemists. In this Review, the syntheses of Aspidosperma and Strychnos alkaloids through dearomatization of indoles are discussed.",

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AU - Ruijter, Eelco

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Y1 - 2019/7/5

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AB - Monoterpenoid indole alkaloids are the major class of tryptamine-derived alkaloids found in nature. Together with their structural complexity, this has attracted great interest from synthetic organic chemists. In this Review, the syntheses of Aspidosperma and Strychnos alkaloids through dearomatization of indoles are discussed.

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KW - biomimetic synthesis

KW - dearomatization

KW - indoles

KW - natural product synthesis

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Total Synthesis of Aspidosperma and Strychnos Alkaloids through Indole Dearomatization

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