TY - JOUR
T1 - Towards a biological geriatric assessment
AU - Tuttle, Camilla S.L.
AU - Maier, Andrea B.
PY - 2018/7/1
Y1 - 2018/7/1
N2 - The aging process occurs gradually, is highly individual, with a high degree of inter and intra-individual differences. As such, within an aging population there is significant variation in regards to extent of age related disease and functional impairment. This variability between individuals is thought to be expressed as biological age. Currently, the comprehensive geriatric assessment (CGA), a multidimensional, interdisciplinary diagnostic process is used to determine an individual's medical, psychological and functional capability at older age. However, while the CGA utilises well-established markers of physical and functional parameters, it does not include any molecular measures that indicate an individual's biological age. Combining functional measures with molecular markers of biological age, could improve the current CGA by identifying individuals undergoing a rapid aging process. In this review, the current knowledge and clinical utility of potential biomarkers of aging are presented. Although no biomarkers indicative of biological age are currently being utilized in the clinical setting promising research advancements would suggest their application in the near future.
AB - The aging process occurs gradually, is highly individual, with a high degree of inter and intra-individual differences. As such, within an aging population there is significant variation in regards to extent of age related disease and functional impairment. This variability between individuals is thought to be expressed as biological age. Currently, the comprehensive geriatric assessment (CGA), a multidimensional, interdisciplinary diagnostic process is used to determine an individual's medical, psychological and functional capability at older age. However, while the CGA utilises well-established markers of physical and functional parameters, it does not include any molecular measures that indicate an individual's biological age. Combining functional measures with molecular markers of biological age, could improve the current CGA by identifying individuals undergoing a rapid aging process. In this review, the current knowledge and clinical utility of potential biomarkers of aging are presented. Although no biomarkers indicative of biological age are currently being utilized in the clinical setting promising research advancements would suggest their application in the near future.
KW - Aged
KW - Aging/physiology
KW - Biomarkers
KW - Case Management/organization & administration
KW - Geriatric Assessment/methods
KW - Humans
KW - Patient Care Team/organization & administration
UR - https://www.scopus.com/pages/publications/85031099192
UR - https://www.scopus.com/inward/citedby.url?scp=85031099192&partnerID=8YFLogxK
U2 - 10.1016/j.exger.2017.09.017
DO - 10.1016/j.exger.2017.09.017
M3 - Review article
C2 - 28964828
AN - SCOPUS:85031099192
SN - 0531-5565
VL - 107
SP - 102
EP - 107
JO - Experimental Gerontology
JF - Experimental Gerontology
ER -