Towards a rational design of faecal transplant analogues

Olaf F.A. Larsen*, Anton H.J. Koning, Peter J. van der Spek, Eric Claassen

*Corresponding author for this work

Research output: Contribution to JournalArticleAcademicpeer-review


Faecal transplants (microbiota transfer) have shown to be promising therapies having a wide range of therapeutic applications. However, current safety considerations hamper further valorisation. As such, well designed faecal transplant analogues provide an interesting alternative to minimize possible safety aspects. However, to date little knowledge on how to rationally design such analogues exists. Here, we show by applying first order basic graph theory that such analogues dedicated to restoring a specific physiological functionality (a microbial guild) should consist of 5–6 species to maximize stability, efficiency, and minimize safety issues and production costs.

Original languageEnglish
Article number5558
Pages (from-to)1-6
Number of pages6
JournalScientific Reports
Publication statusPublished - 3 Apr 2019


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