TY - JOUR
T1 - Towards a rational design of faecal transplant analogues
AU - Larsen, Olaf F.A.
AU - Koning, Anton H.J.
AU - van der Spek, Peter J.
AU - Claassen, Eric
PY - 2019/4/3
Y1 - 2019/4/3
N2 - Faecal transplants (microbiota transfer) have shown to be promising therapies having a wide range of therapeutic applications. However, current safety considerations hamper further valorisation. As such, well designed faecal transplant analogues provide an interesting alternative to minimize possible safety aspects. However, to date little knowledge on how to rationally design such analogues exists. Here, we show by applying first order basic graph theory that such analogues dedicated to restoring a specific physiological functionality (a microbial guild) should consist of 5–6 species to maximize stability, efficiency, and minimize safety issues and production costs.
AB - Faecal transplants (microbiota transfer) have shown to be promising therapies having a wide range of therapeutic applications. However, current safety considerations hamper further valorisation. As such, well designed faecal transplant analogues provide an interesting alternative to minimize possible safety aspects. However, to date little knowledge on how to rationally design such analogues exists. Here, we show by applying first order basic graph theory that such analogues dedicated to restoring a specific physiological functionality (a microbial guild) should consist of 5–6 species to maximize stability, efficiency, and minimize safety issues and production costs.
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U2 - 10.1038/s41598-019-42043-x
DO - 10.1038/s41598-019-42043-x
M3 - Article
C2 - 30944372
AN - SCOPUS:85063776285
SN - 2045-2322
VL - 9
SP - 1
EP - 6
JO - Scientific Reports
JF - Scientific Reports
M1 - 5558
ER -
