Towards a rational design of faecal transplant analogues

Olaf F.A. Larsen; Anton H.J. Koning; Peter J. van der Spek; Eric Claassen

doi:10.1038/s41598-019-42043-x

Towards a rational design of faecal transplant analogues

Olaf F.A. Larsen^*, Anton H.J. Koning, Peter J. van der Spek, Eric Claassen

^*Corresponding author for this work

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

Faecal transplants (microbiota transfer) have shown to be promising therapies having a wide range of therapeutic applications. However, current safety considerations hamper further valorisation. As such, well designed faecal transplant analogues provide an interesting alternative to minimize possible safety aspects. However, to date little knowledge on how to rationally design such analogues exists. Here, we show by applying first order basic graph theory that such analogues dedicated to restoring a specific physiological functionality (a microbial guild) should consist of 5–6 species to maximize stability, efficiency, and minimize safety issues and production costs.

Original language	English
Article number	5558
Pages (from-to)	1-6
Number of pages	6
Journal	Scientific Reports
Volume	9
DOIs	https://doi.org/10.1038/s41598-019-42043-x
Publication status	Published - 3 Apr 2019

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1038/s41598-019-42043-x

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447603

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AU - Koning, Anton H.J.

AU - van der Spek, Peter J.

AU - Claassen, Eric

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AB - Faecal transplants (microbiota transfer) have shown to be promising therapies having a wide range of therapeutic applications. However, current safety considerations hamper further valorisation. As such, well designed faecal transplant analogues provide an interesting alternative to minimize possible safety aspects. However, to date little knowledge on how to rationally design such analogues exists. Here, we show by applying first order basic graph theory that such analogues dedicated to restoring a specific physiological functionality (a microbial guild) should consist of 5–6 species to maximize stability, efficiency, and minimize safety issues and production costs.

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Towards a rational design of faecal transplant analogues

Abstract

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