Toxicokinetic-toxicodynamic modelling of quantal and graded sub-lethal endpoints - a brief discussion of concepts.

R. Ashauer, A. Agatz, C. Albert, V. Ducrot, N. Galic, A.J. Hendriks, T. Jager, A. Kretschmann, I. O'Connor, M.N. Rubach, A.M. Nyman, W. Schmitt, J. Stadnicka, P. van den Brink, T.G. Preuss

    Research output: Contribution to JournalArticleAcademicpeer-review

    Abstract

    We report on the advantages and problems of using toxicokinetic-toxicodynamic (TKTD) models for the analysis, understanding, and simulation of sublethal effects. Only a few toxicodynamic approaches for sublethal effects are available. These differ in their effect mechanism and emphasis on linkages between endpoints. We discuss how the distinction between quantal and graded endpoints and the type of linkage between endpoints can guide model design and selection. Strengths and limitations of two main approaches and possible ways forward are outlined. © 2011 SETAC.
    Original languageEnglish
    Pages (from-to)2519-2524
    JournalEnvironmental Toxicology and Chemistry
    Volume30
    DOIs
    Publication statusPublished - 2011

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