Toxicokinetics and toxicodynamics of lead in the soil invertebrate Enchytraeus crypticus

Lulu Zhang, Cornelis A.M. Van Gestel*

*Corresponding author for this work

    Research output: Contribution to JournalArticleAcademicpeer-review

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    Abstract

    The aim of the present study was to link Pb toxicokinetics to toxicodynamics in Enchytraeus crypticus. The enchytraeids were exposed for 14 d to different Pb concentrations (uptake phase) in natural Lufa 2.2 soil, followed by a 14-d elimination phase in clean soil. Pb accumulation and enchytraeid mortality were determined at different time intervals. At each exposure concentration, internal Pb concentration increased with exposure time and achieved equilibrium in approximately 7 d. Median lethal concentration (LC50) based on total Pb concentration in soil decreased with exposure time, but did not reach a steady-state level. Pb toxicity, therefore, showed a delay compared to accumulation in E. crypticus. LC50s based on internal Pb concentrations in the surviving animals did reach steady state in approx.14 d, suggesting that linking toxicokinetics to toxicodynamics may reduce the effects of time. This study highlighted that exposure time, as an important factor in metal uptake and toxicity, should be taken into account in ecotoxicological tests for risk assessment.

    Original languageEnglish
    Pages (from-to)534-541
    Number of pages8
    JournalEnvironmental Pollution
    Volume225
    Early online date17 Mar 2017
    DOIs
    Publication statusPublished - Jun 2017

    Keywords

    • Enchytraeus crypticus
    • Lead
    • Toxicodynamics
    • Toxicokinetics

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