Trans fatty acids and cardiovascular health: research completed?

I.A. Brouwer, A.J. Wanders, M.B. Katan

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

This review asks the question if further research on trans fatty acids and cardiovascular health is needed. We therefore review the evidence from human studies on trans fatty acids and cardiovascular health, and provide a quantitative review of effects of trans fatty acid intake on lipoproteins. The results show that the effect of industrially produced trans fatty acids on heart health seen in observational studies is larger than predicted from changes in lipoprotein concentrations. There is debate on the effect of ruminant trans fatty acids and cardiovascular disease. Of special interest is conjugated linoleic acid (CLA), which is produced industrially for sale as supplements. Observational studies do not show higher risks of cardiovascular disease with higher intakes of ruminant trans fatty acids. However, CLA, industrial and ruminant trans fatty acids all raise plasma low-density lipoprotein and the total to high-density lipoprotein ratio. Gram for gram, all trans fatty acids have largely the same effect on blood lipoproteins. In conclusion, the detrimental effects of industrial trans fatty acids on heart health are beyond dispute. The exact size of effect will remain hard to determine. Further research is warranted on the effects of ruminant trans fatty acids and CLA on cardiovascular disease and its risk factors. © 2013 Macmillan Publishers Limited.
Original languageEnglish
Pages (from-to)541-547
JournalEuropean Journal of Clinical Nutrition
Volume67
Issue number5
Early online date27 Mar 2013
DOIs
Publication statusPublished - 2013

Fingerprint

Trans Fatty Acids
Health
Research
Ruminants
Conjugated Linoleic Acids
Lipoproteins
Cardiovascular Diseases
Observational Studies
Dissent and Disputes
HDL Lipoproteins
LDL Lipoproteins

Cite this

@article{c7a6987a16e64f11a4f15fd54eaf451b,
title = "Trans fatty acids and cardiovascular health: research completed?",
abstract = "This review asks the question if further research on trans fatty acids and cardiovascular health is needed. We therefore review the evidence from human studies on trans fatty acids and cardiovascular health, and provide a quantitative review of effects of trans fatty acid intake on lipoproteins. The results show that the effect of industrially produced trans fatty acids on heart health seen in observational studies is larger than predicted from changes in lipoprotein concentrations. There is debate on the effect of ruminant trans fatty acids and cardiovascular disease. Of special interest is conjugated linoleic acid (CLA), which is produced industrially for sale as supplements. Observational studies do not show higher risks of cardiovascular disease with higher intakes of ruminant trans fatty acids. However, CLA, industrial and ruminant trans fatty acids all raise plasma low-density lipoprotein and the total to high-density lipoprotein ratio. Gram for gram, all trans fatty acids have largely the same effect on blood lipoproteins. In conclusion, the detrimental effects of industrial trans fatty acids on heart health are beyond dispute. The exact size of effect will remain hard to determine. Further research is warranted on the effects of ruminant trans fatty acids and CLA on cardiovascular disease and its risk factors. {\circledC} 2013 Macmillan Publishers Limited.",
author = "I.A. Brouwer and A.J. Wanders and M.B. Katan",
year = "2013",
doi = "10.1038/ejcn.2013.43",
language = "English",
volume = "67",
pages = "541--547",
journal = "European Journal of Clinical Nutrition",
issn = "0954-3007",
publisher = "Nature Publishing Group",
number = "5",

}

Trans fatty acids and cardiovascular health: research completed? / Brouwer, I.A.; Wanders, A.J.; Katan, M.B.

In: European Journal of Clinical Nutrition, Vol. 67, No. 5, 2013, p. 541-547.

Research output: Contribution to JournalArticleAcademicpeer-review

TY - JOUR

T1 - Trans fatty acids and cardiovascular health: research completed?

AU - Brouwer, I.A.

AU - Wanders, A.J.

AU - Katan, M.B.

PY - 2013

Y1 - 2013

N2 - This review asks the question if further research on trans fatty acids and cardiovascular health is needed. We therefore review the evidence from human studies on trans fatty acids and cardiovascular health, and provide a quantitative review of effects of trans fatty acid intake on lipoproteins. The results show that the effect of industrially produced trans fatty acids on heart health seen in observational studies is larger than predicted from changes in lipoprotein concentrations. There is debate on the effect of ruminant trans fatty acids and cardiovascular disease. Of special interest is conjugated linoleic acid (CLA), which is produced industrially for sale as supplements. Observational studies do not show higher risks of cardiovascular disease with higher intakes of ruminant trans fatty acids. However, CLA, industrial and ruminant trans fatty acids all raise plasma low-density lipoprotein and the total to high-density lipoprotein ratio. Gram for gram, all trans fatty acids have largely the same effect on blood lipoproteins. In conclusion, the detrimental effects of industrial trans fatty acids on heart health are beyond dispute. The exact size of effect will remain hard to determine. Further research is warranted on the effects of ruminant trans fatty acids and CLA on cardiovascular disease and its risk factors. © 2013 Macmillan Publishers Limited.

AB - This review asks the question if further research on trans fatty acids and cardiovascular health is needed. We therefore review the evidence from human studies on trans fatty acids and cardiovascular health, and provide a quantitative review of effects of trans fatty acid intake on lipoproteins. The results show that the effect of industrially produced trans fatty acids on heart health seen in observational studies is larger than predicted from changes in lipoprotein concentrations. There is debate on the effect of ruminant trans fatty acids and cardiovascular disease. Of special interest is conjugated linoleic acid (CLA), which is produced industrially for sale as supplements. Observational studies do not show higher risks of cardiovascular disease with higher intakes of ruminant trans fatty acids. However, CLA, industrial and ruminant trans fatty acids all raise plasma low-density lipoprotein and the total to high-density lipoprotein ratio. Gram for gram, all trans fatty acids have largely the same effect on blood lipoproteins. In conclusion, the detrimental effects of industrial trans fatty acids on heart health are beyond dispute. The exact size of effect will remain hard to determine. Further research is warranted on the effects of ruminant trans fatty acids and CLA on cardiovascular disease and its risk factors. © 2013 Macmillan Publishers Limited.

U2 - 10.1038/ejcn.2013.43

DO - 10.1038/ejcn.2013.43

M3 - Article

VL - 67

SP - 541

EP - 547

JO - European Journal of Clinical Nutrition

JF - European Journal of Clinical Nutrition

SN - 0954-3007

IS - 5

ER -