Transcription Factor-Based Fate Specification and Forward Programming for Neural Regeneration

Lea Flitsch, Karen Laupman, Oliver Brüstle*

*Corresponding author for this work

Research output: Contribution to JournalReview articleAcademicpeer-review

Abstract

Traditionally, in vitro generation of donor cells for brain repair has been dominated by the application of extrinsic growth factors and morphogens. Recent advances in cell engineering strategies such as reprogramming of somatic cells into induced pluripotent stem cells and direct cell fate conversion have impressively demonstrated the feasibility to manipulate cell identities by the overexpression of cell fate-determining transcription factors. These strategies are now increasingly implemented for transcription factor-guided differentiation of neural precursors and forward programming of pluripotent stem cells toward specific neural subtypes. This review covers major achievements, pros and cons, as well as future prospects of transcription factor-based cell fate specification and the applicability of these approaches for the generation of donor cells for brain repair.
Original languageEnglish
Article number121
Pages (from-to)1/22
Number of pages22
JournalFrontiers in Cellular Neuroscience
Volume14
DOIs
Publication statusPublished - 20 May 2020

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