Abstract
This work investigates the role of isochores during preimplantation process. Using RNA-seq data from human and mouse preimplantation stages, we created the spatio-temporal transcriptional profiles of the isochores during preimplantation. We found that from early to late stages, GC-rich isochores increase their expression while GC-poor ones decrease it. Network analysis revealed that modules with few coexpressed isochores are GC-poorer than medium-large ones, characterized by an opposite expression as preimplantation advances, decreasing and increasing respectively. Our results reveal a functional contribution of the isochores, supporting the presence of structural-functional interactions during maturation and early-embryonic development.
Original language | English |
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Pages (from-to) | 2297-2306 |
Number of pages | 10 |
Journal | FEBS Letters |
DOIs | |
Publication status | Published - 1 Jul 2016 |
Externally published | Yes |
Keywords
- base composition
- expression
- GC level
- isochores
- preimplantation
- RNA-seq
- transcriptome