Transcriptome activity of isochores during preimplantation process in human and mouse

Carl Barton, Costas S. Iliopoulos, Solon P. Pissis, Stilianos Arhondakis*

*Corresponding author for this work

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

This work investigates the role of isochores during preimplantation process. Using RNA-seq data from human and mouse preimplantation stages, we created the spatio-temporal transcriptional profiles of the isochores during preimplantation. We found that from early to late stages, GC-rich isochores increase their expression while GC-poor ones decrease it. Network analysis revealed that modules with few coexpressed isochores are GC-poorer than medium-large ones, characterized by an opposite expression as preimplantation advances, decreasing and increasing respectively. Our results reveal a functional contribution of the isochores, supporting the presence of structural-functional interactions during maturation and early-embryonic development.

Original languageEnglish
Pages (from-to)2297-2306
Number of pages10
JournalFEBS Letters
DOIs
Publication statusPublished - 1 Jul 2016
Externally publishedYes

Keywords

  • base composition
  • expression
  • GC level
  • isochores
  • preimplantation
  • RNA-seq
  • transcriptome

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