Abstract
Trifluoromethyl vinyl sulfide, a potential building block for pharmaceutically and agrochemically relevant products, is prepared and used for the first time in high-pressure-mediated 1,3-dipolar cycloaddition reactions with nitrones to synthesize (trifluoromethyl)sulfanyl isoxazolidines.
Original language | English |
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Pages (from-to) | 1779-1789 |
Number of pages | 11 |
Journal | Journal of Organic Chemistry |
Volume | 83 |
Issue number | 4 |
Early online date | 10 Jan 2018 |
DOIs | |
Publication status | Published - 16 Feb 2018 |
Funding
This work has been supported by the FP7Marie Curie Actions of the European Commission via the ITN ECHONET Network (MCITN-2012-316379) and NWO via the Planetary and Exoplanetary Science program (PEPSci) and the Dutch Astrochemistry Network (DAN). We thank Dr. Paul B. White for his help in the assignment of the diastereo-and regioisomers, and Birgit Kuhn (Bayer AG) for the helpful discussions.
Funders | Funder number |
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Dutch Astrochemistry Network | |
FP7Marie Curie Actions of the European Commission | |
ITN ECHONET Network | MCITN-2012-316379 |
Seventh Framework Programme | 316379 |
Nederlandse Organisatie voor Wetenschappelijk Onderzoek |