TRPV4 deficiency causes sexual dimorphism in bone metabolism and osteoporotic fracture risk

B.C.J. van der Eerden; L. Oei; P. Roschger; N. Fratzl-Zelman; J.G.J. Hoenderop; N.M. van Schoor; U. Pettersson-Kymmer; M. Schreuders-Koedam; A. G. Uitterlinden; A. Hofman; M. Suzuki; K. Klaushofer; C. Ohlsson; P.T.A.M. Lips; F. Rivadeneira; R.J.M. Bindels; J.P.T.M. van Leeuwen

doi:10.1016/j.bone.2013.09.017

TRPV4 deficiency causes sexual dimorphism in bone metabolism and osteoporotic fracture risk

B.C.J. van der Eerden, L. Oei, P. Roschger, N. Fratzl-Zelman, J.G.J. Hoenderop, N.M. van Schoor, U. Pettersson-Kymmer, M. Schreuders-Koedam, A. G. Uitterlinden, A. Hofman, M. Suzuki, K. Klaushofer, C. Ohlsson, P.T.A.M. Lips, F. Rivadeneira, R.J.M. Bindels, J.P.T.M. van Leeuwen

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

We explored the role of transient receptor potential vanilloid 4 (TRPV4) in murine bone metabolism and association of TRPV4 gene variants with fractures in humans. Urinary and histomorphometrical analyses demonstrated reduced osteoclast activity and numbers in male Trpv4

Original language	English
Pages (from-to)	443-454
Journal	Bone
Volume	57
Issue number	2
DOIs	https://doi.org/10.1016/j.bone.2013.09.017
Publication status	Published - 2013

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van der Eerden, B. C. J., Oei, L., Roschger, P., Fratzl-Zelman, N., Hoenderop, J. G. J., van Schoor, N. M., Pettersson-Kymmer, U., Schreuders-Koedam, M., Uitterlinden, A. G., Hofman, A., Suzuki, M., Klaushofer, K., Ohlsson, C., Lips, P. T. A. M., Rivadeneira, F., Bindels, R. J. M., & van Leeuwen, J. P. T. M. (2013). TRPV4 deficiency causes sexual dimorphism in bone metabolism and osteoporotic fracture risk. Bone, 57(2), 443-454. https://doi.org/10.1016/j.bone.2013.09.017

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title = "TRPV4 deficiency causes sexual dimorphism in bone metabolism and osteoporotic fracture risk",

abstract = "We explored the role of transient receptor potential vanilloid 4 (TRPV4) in murine bone metabolism and association of TRPV4 gene variants with fractures in humans. Urinary and histomorphometrical analyses demonstrated reduced osteoclast activity and numbers in male Trpv4",

author = "{van der Eerden}, B.C.J. and L. Oei and P. Roschger and N. Fratzl-Zelman and J.G.J. Hoenderop and {van Schoor}, N.M. and U. Pettersson-Kymmer and M. Schreuders-Koedam and Uitterlinden, {A. G.} and A. Hofman and M. Suzuki and K. Klaushofer and C. Ohlsson and P.T.A.M. Lips and F. Rivadeneira and R.J.M. Bindels and {van Leeuwen}, J.P.T.M.",

year = "2013",

doi = "10.1016/j.bone.2013.09.017",

language = "English",

volume = "57",

pages = "443--454",

journal = "Bone",

issn = "8756-3282",

publisher = "Elsevier Inc.",

number = "2",

}

van der Eerden, BCJ, Oei, L, Roschger, P, Fratzl-Zelman, N, Hoenderop, JGJ, van Schoor, NM, Pettersson-Kymmer, U, Schreuders-Koedam, M, Uitterlinden, AG, Hofman, A, Suzuki, M, Klaushofer, K, Ohlsson, C, Lips, PTAM, Rivadeneira, F, Bindels, RJM & van Leeuwen, JPTM 2013, 'TRPV4 deficiency causes sexual dimorphism in bone metabolism and osteoporotic fracture risk', Bone, vol. 57, no. 2, pp. 443-454. https://doi.org/10.1016/j.bone.2013.09.017

TY - JOUR

T1 - TRPV4 deficiency causes sexual dimorphism in bone metabolism and osteoporotic fracture risk

AU - van der Eerden, B.C.J.

AU - Oei, L.

AU - Roschger, P.

AU - Fratzl-Zelman, N.

AU - Hoenderop, J.G.J.

AU - van Schoor, N.M.

AU - Pettersson-Kymmer, U.

AU - Schreuders-Koedam, M.

AU - Uitterlinden, A. G.

AU - Hofman, A.

AU - Suzuki, M.

AU - Klaushofer, K.

AU - Ohlsson, C.

AU - Lips, P.T.A.M.

AU - Rivadeneira, F.

AU - Bindels, R.J.M.

AU - van Leeuwen, J.P.T.M.

PY - 2013

Y1 - 2013

N2 - We explored the role of transient receptor potential vanilloid 4 (TRPV4) in murine bone metabolism and association of TRPV4 gene variants with fractures in humans. Urinary and histomorphometrical analyses demonstrated reduced osteoclast activity and numbers in male Trpv4

AB - We explored the role of transient receptor potential vanilloid 4 (TRPV4) in murine bone metabolism and association of TRPV4 gene variants with fractures in humans. Urinary and histomorphometrical analyses demonstrated reduced osteoclast activity and numbers in male Trpv4

U2 - 10.1016/j.bone.2013.09.017

DO - 10.1016/j.bone.2013.09.017

M3 - Article

SN - 8756-3282

VL - 57

SP - 443

EP - 454

JO - Bone

JF - Bone

IS - 2

ER -

TRPV4 deficiency causes sexual dimorphism in bone metabolism and osteoporotic fracture risk

Abstract

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