Abstract
Psychotic disorders are characterized by problems in interpersonal, social functioning. Paranoid ideation reflects severe suspiciousness and distrust in others. However, the neural mechanisms underlying these social symptoms are largely unknown. Here, we discuss studies investigating trust in psychosis by means of the interactive trust game, and through trustworthiness ratings of faces. Across all the stages of the continuum reduced baseline trust was found in various studies, possibly suggesting a trait-like vulnerability for psychosis. In repeated interactions chronic patients engage less in trust honouring interactions, although they show intact reactions to facial expressions. Overall, first-episode patients and individuals at high risk for psychosis also show reduced trust, but are able to learn to trust over repeated interactions. Several factors that can influence trust are discussed. At the neural level, differential activation in brain regions associated with theory of mind and reward processing were found in individuals with psychosis across illness stages. Theoretical accounts considering motivation, cognition and affect are discussed and suggestions for future research are formulated.
Original language | English |
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Title of host publication | The Neurobiology of Trust |
Editors | Frank Krueger |
Publisher | Cambridge University Press |
Chapter | 16 |
Pages | 389-431 |
Number of pages | 43 |
ISBN (Electronic) | 9781108770880 |
ISBN (Print) | 9781108488563 |
DOIs | |
Publication status | Published - Dec 2021 |