Twin's Birth-Order Differences in Height and Body Mass Index From Birth to Old Age: A Pooled Study of 26 Twin Cohorts Participating in the CODATwins Project

Y. Yokoyama, A. Jelenkovic, R. Sund, J. Sung, J.L. Hopper, S. Ooki, K. Heikkilä, S. Aaltonen, A.D. Tarnoki, D.L. Tarnoki, G. Willemsen, M. Bartels, C.E.M. van Beijsterveldt, K.J. Saudino, T.L. Cutler, T.L. Nelson, K.E. Whitfield, J. Wardle, C.H. Llewellyn, A. FisherM. He, X. Ding, M. Bjerregaard-Andersen, H. Beck-Nielsen, M. Sodemann, Y.M. Song, S. Yang, K. Lee, H.U. Jeong, A. Knafo-Noam, D. Mankuta, L. Abramson, S.A. Burt, K.L. Klump, J.R. Ordonana, J.F. Sanchez-Romera, L. Colodro-Conde, J.R. Harris, I. Brandt, T. Sevenius Nilsen, J.M. Craig, R. Saffery, F. Ji, F. Ning, Z. Pang, L. Dubois, M. Boivin, M. Brendgen, G. Dionne, F. Vitaro, N.G. Martin, S.E. Medland, G.W. Montgomery, P.K.E. Magnusson, N.L. Pedersen, A.K. Dahl Aslan, P. Tynelius, C.M.A. Haworth, R. Plomin, E. Rebato, R.J. Rose, J.H. Goldberg, F. Rasmussen, Y.M. Hur, T.I.A. Sørensen, D.I. Boomsma, J. Kaprio, K. Silventoinen

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

We analyzed birth order differences in means and variances of height and body mass index (BMI) in monozygotic (MZ) and dizygotic (DZ) twins from infancy to old age. The data were derived from the international CODATwins database. The total number of height and BMI measures from 0.5 to 79.5 years of age was 397,466. As expected, first-born twins had greater birth weight than second-born twins. With respect to height, first-born twins were slightly taller than second-born twins in childhood. After adjusting the results for birth weight, the birth order differences decreased and were no longer statistically significant. First-born twins had greater BMI than the second-born twins over childhood and adolescence. After adjusting the results for birth weight, birth order was still associated with BMI until 12 years of age. No interaction effect between birth order and zygosity was found. Only limited evidence was found that birth order influenced variances of height or BMI. The results were similar among boys and girls and also in MZ and DZ twins. Overall, the differences in height and BMI between first- and second-born twins were modest even in early childhood, while adjustment for birth weight reduced the birth order differences but did not remove them for BMI.
Original languageEnglish
Pages (from-to)112-124
JournalTwin Research and Human Genetics
Volume19
Issue number2
DOIs
Publication statusPublished - 2016

Cohort Studies

  • Netherlands Twin Register (NTR)

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