Two-locus linkage analysis applied to putative quantitative trait loci for Lp(a) levels

M. Beekman; B.T. Heijmans; N.G. Martin; J.B. Whitfield; N.L. Pedersen; U. DeFaire; H. Snieder; N. Lakenberg; P. de Knijff; R.R. Frants; G.J.B van Ommen; C. Kluft; G.P. Vogler; P.E. Slagboom; D.I. Boomsma

doi:10.1375/136905203322296692

Two-locus linkage analysis applied to putative quantitative trait loci for Lp(a) levels

M. Beekman, B.T. Heijmans, N.G. Martin, J.B. Whitfield, N.L. Pedersen, U. DeFaire, H. Snieder, N. Lakenberg, P. de Knijff, R.R. Frants, G.J.B van Ommen, C. Kluft, G.P. Vogler, P.E. Slagboom, D.I. Boomsma

Biological Psychology

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Abstract

Plasma levels of lipoprotein(a) - Lp(a) - are associated with cardiovascular risk (Danesh et al., 2000) and were long believed to be influenced by the LPA locus on chromosome 6q27 only. However, a recent report of Broeckel et al. (2002) suggested the presence of a second quantitative trait locus on chromosome 1 influencing Lp(a) levels. Using a two-locus model, we found no evidence for an additional Lp(a) locus on chromosome 1 in a linkage study among 483 dizygotic twin pairs.

Original language	English
Pages (from-to)	322-324
Journal	Twin Research
Volume	6
Issue number	4
DOIs	https://doi.org/10.1375/136905203322296692
Publication status	Published - 2003

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Beekman Twin Research 6(4) 2003 uFinal published version, 85.9 KB

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Beekman, M., Heijmans, B. T., Martin, N. G., Whitfield, J. B., Pedersen, N. L., DeFaire, U., Snieder, H., Lakenberg, N., de Knijff, P., Frants, R. R., van Ommen, G. J. B., Kluft, C., Vogler, G. P., Slagboom, P. E., & Boomsma, D. I. (2003). Two-locus linkage analysis applied to putative quantitative trait loci for Lp(a) levels. Twin Research, 6(4), 322-324. https://doi.org/10.1375/136905203322296692

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title = "Two-locus linkage analysis applied to putative quantitative trait loci for Lp(a) levels",

abstract = "Plasma levels of lipoprotein(a) - Lp(a) - are associated with cardiovascular risk (Danesh et al., 2000) and were long believed to be influenced by the LPA locus on chromosome 6q27 only. However, a recent report of Broeckel et al. (2002) suggested the presence of a second quantitative trait locus on chromosome 1 influencing Lp(a) levels. Using a two-locus model, we found no evidence for an additional Lp(a) locus on chromosome 1 in a linkage study among 483 dizygotic twin pairs.",

author = "M. Beekman and B.T. Heijmans and N.G. Martin and J.B. Whitfield and N.L. Pedersen and U. DeFaire and H. Snieder and N. Lakenberg and {de Knijff}, P. and R.R. Frants and {van Ommen}, G.J.B and C. Kluft and G.P. Vogler and P.E. Slagboom and D.I. Boomsma",

year = "2003",

doi = "10.1375/136905203322296692",

language = "English",

volume = "6",

pages = "322--324",

journal = "Twin Research",

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publisher = "Australian Academic Press",

number = "4",

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Beekman, M, Heijmans, BT, Martin, NG, Whitfield, JB, Pedersen, NL, DeFaire, U, Snieder, H, Lakenberg, N, de Knijff, P, Frants, RR, van Ommen, GJB, Kluft, C, Vogler, GP, Slagboom, PE & Boomsma, DI 2003, 'Two-locus linkage analysis applied to putative quantitative trait loci for Lp(a) levels', Twin Research, vol. 6, no. 4, pp. 322-324. https://doi.org/10.1375/136905203322296692

TY - JOUR

T1 - Two-locus linkage analysis applied to putative quantitative trait loci for Lp(a) levels

AU - Beekman, M.

AU - Heijmans, B.T.

AU - Martin, N.G.

AU - Whitfield, J.B.

AU - Pedersen, N.L.

AU - DeFaire, U.

AU - Snieder, H.

AU - Lakenberg, N.

AU - de Knijff, P.

AU - Frants, R.R.

AU - van Ommen, G.J.B

AU - Kluft, C.

AU - Vogler, G.P.

AU - Slagboom, P.E.

AU - Boomsma, D.I.

PY - 2003

Y1 - 2003

N2 - Plasma levels of lipoprotein(a) - Lp(a) - are associated with cardiovascular risk (Danesh et al., 2000) and were long believed to be influenced by the LPA locus on chromosome 6q27 only. However, a recent report of Broeckel et al. (2002) suggested the presence of a second quantitative trait locus on chromosome 1 influencing Lp(a) levels. Using a two-locus model, we found no evidence for an additional Lp(a) locus on chromosome 1 in a linkage study among 483 dizygotic twin pairs.

AB - Plasma levels of lipoprotein(a) - Lp(a) - are associated with cardiovascular risk (Danesh et al., 2000) and were long believed to be influenced by the LPA locus on chromosome 6q27 only. However, a recent report of Broeckel et al. (2002) suggested the presence of a second quantitative trait locus on chromosome 1 influencing Lp(a) levels. Using a two-locus model, we found no evidence for an additional Lp(a) locus on chromosome 1 in a linkage study among 483 dizygotic twin pairs.

U2 - 10.1375/136905203322296692

DO - 10.1375/136905203322296692

M3 - Article

SN - 1369-0523

VL - 6

SP - 322

EP - 324

JO - Twin Research

JF - Twin Research

IS - 4

ER -

Two-locus linkage analysis applied to putative quantitative trait loci for Lp(a) levels

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