Two prospective studies found that elevated 2-hr glucose predicted male mortality independent of fasting glucose and HbA1c

Q. Qiao, J.M. Dekker, F. de Vegt, G. Nijpels, A. Nissinen, C.D.A. Stehouwer, L.M. Bouter, R.J. Heine, J. Tuomilehto

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    Abstract

    OBJECTIVE: To quantify the relative contribution of elevated 2-hr glucose, fasting glucose (FPG), and HbA1c to all-cause mortality.

    STUDY DESIGN AND SETTING: A joint analysis of two prospective studies with baseline glycemia measurements.

    RESULTS: The multivariate adjusted hazard ratios (HRs) corresponding to a one standard deviation increase in HbA1c were 1.14 (95% CI 1.03-1.25), 1.08 (0.98-1.19) for FPG and 1.15 (1.05-1.27) for 2-hr glucose, respectively. Entering the 2-hr glucose to the model based on the FPG and HbA1c significantly improved the prediction of mortality, whereas neither FPG, nor HbA1c added significant information once 2-hr glucose was in the models. In subjects with FPG <7.0 mmol/L and HbA1c < or = 6.5%, the HR was 1.35 (1.03-1.78) in men with 2-hr glucose > or = 7.8 mmol/L compared with men with 2-hr glucose <7.8 mmol/L.

    CONCLUSION: Elevated 2-hr glucose was a predictor of mortality independent of the levels of fasting glucose and HbA1c.

    Original languageEnglish
    Pages (from-to)590-596
    Number of pages7
    JournalJournal of Clinical Epidemiology
    Volume57
    Issue number6
    DOIs
    Publication statusPublished - Jun 2004

    Keywords

    • Aged
    • Aged, 80 and over
    • Blood Glucose
    • Cause of Death
    • Diabetes Mellitus
    • Fasting
    • Glucose Tolerance Test
    • Glycated Hemoglobin A
    • Humans
    • Male
    • Middle Aged
    • Predictive Value of Tests
    • Proportional Hazards Models
    • Prospective Studies
    • Journal Article
    • Research Support, Non-U.S. Gov't
    • Research Support, U.S. Gov't, P.H.S.

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