Two prospective studies found that elevated 2-hr glucose predicted male mortality independent of fasting glucose and HbA1c

Q. Qiao; J.M. Dekker; F. de Vegt; G. Nijpels; A. Nissinen; C.D.A. Stehouwer; L.M. Bouter; R.J. Heine; J. Tuomilehto

doi:10.1016/j.jclinepi.2003.10.007

Two prospective studies found that elevated 2-hr glucose predicted male mortality independent of fasting glucose and HbA1c

Q. Qiao, J.M. Dekker, F. de Vegt, G. Nijpels, A. Nissinen, C.D.A. Stehouwer, L.M. Bouter, R.J. Heine, J. Tuomilehto

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Abstract

OBJECTIVE: To quantify the relative contribution of elevated 2-hr glucose, fasting glucose (FPG), and HbA1c to all-cause mortality.

STUDY DESIGN AND SETTING: A joint analysis of two prospective studies with baseline glycemia measurements.

RESULTS: The multivariate adjusted hazard ratios (HRs) corresponding to a one standard deviation increase in HbA1c were 1.14 (95% CI 1.03-1.25), 1.08 (0.98-1.19) for FPG and 1.15 (1.05-1.27) for 2-hr glucose, respectively. Entering the 2-hr glucose to the model based on the FPG and HbA1c significantly improved the prediction of mortality, whereas neither FPG, nor HbA1c added significant information once 2-hr glucose was in the models. In subjects with FPG <7.0 mmol/L and HbA1c < or = 6.5%, the HR was 1.35 (1.03-1.78) in men with 2-hr glucose > or = 7.8 mmol/L compared with men with 2-hr glucose <7.8 mmol/L.

CONCLUSION: Elevated 2-hr glucose was a predictor of mortality independent of the levels of fasting glucose and HbA1c.

Original language	English
Pages (from-to)	590-596
Number of pages	7
Journal	Journal of Clinical Epidemiology
Volume	57
Issue number	6
DOIs	https://doi.org/10.1016/j.jclinepi.2003.10.007
Publication status	Published - Jun 2004

Keywords

Aged
Aged, 80 and over
Blood Glucose
Cause of Death
Diabetes Mellitus
Fasting
Glucose Tolerance Test
Glycated Hemoglobin A
Humans
Male
Middle Aged
Predictive Value of Tests
Proportional Hazards Models
Prospective Studies
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

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title = "Two prospective studies found that elevated 2-hr glucose predicted male mortality independent of fasting glucose and HbA1c",

abstract = "OBJECTIVE: To quantify the relative contribution of elevated 2-hr glucose, fasting glucose (FPG), and HbA1c to all-cause mortality.STUDY DESIGN AND SETTING: A joint analysis of two prospective studies with baseline glycemia measurements.RESULTS: The multivariate adjusted hazard ratios (HRs) corresponding to a one standard deviation increase in HbA1c were 1.14 (95% CI 1.03-1.25), 1.08 (0.98-1.19) for FPG and 1.15 (1.05-1.27) for 2-hr glucose, respectively. Entering the 2-hr glucose to the model based on the FPG and HbA1c significantly improved the prediction of mortality, whereas neither FPG, nor HbA1c added significant information once 2-hr glucose was in the models. In subjects with FPG <7.0 mmol/L and HbA1c < or = 6.5%, the HR was 1.35 (1.03-1.78) in men with 2-hr glucose > or = 7.8 mmol/L compared with men with 2-hr glucose <7.8 mmol/L.CONCLUSION: Elevated 2-hr glucose was a predictor of mortality independent of the levels of fasting glucose and HbA1c.",

keywords = "Aged, Aged, 80 and over, Blood Glucose, Cause of Death, Diabetes Mellitus, Fasting, Glucose Tolerance Test, Glycated Hemoglobin A, Humans, Male, Middle Aged, Predictive Value of Tests, Proportional Hazards Models, Prospective Studies, Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.",

author = "Q. Qiao and J.M. Dekker and {de Vegt}, F. and G. Nijpels and A. Nissinen and C.D.A. Stehouwer and L.M. Bouter and R.J. Heine and J. Tuomilehto",

year = "2004",

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doi = "10.1016/j.jclinepi.2003.10.007",

language = "English",

volume = "57",

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journal = "Journal of Clinical Epidemiology",

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T1 - Two prospective studies found that elevated 2-hr glucose predicted male mortality independent of fasting glucose and HbA1c

AU - Qiao, Q.

AU - Dekker, J.M.

AU - de Vegt, F.

AU - Nijpels, G.

AU - Nissinen, A.

AU - Stehouwer, C.D.A.

AU - Bouter, L.M.

AU - Heine, R.J.

AU - Tuomilehto, J.

PY - 2004/6

Y1 - 2004/6

N2 - OBJECTIVE: To quantify the relative contribution of elevated 2-hr glucose, fasting glucose (FPG), and HbA1c to all-cause mortality.STUDY DESIGN AND SETTING: A joint analysis of two prospective studies with baseline glycemia measurements.RESULTS: The multivariate adjusted hazard ratios (HRs) corresponding to a one standard deviation increase in HbA1c were 1.14 (95% CI 1.03-1.25), 1.08 (0.98-1.19) for FPG and 1.15 (1.05-1.27) for 2-hr glucose, respectively. Entering the 2-hr glucose to the model based on the FPG and HbA1c significantly improved the prediction of mortality, whereas neither FPG, nor HbA1c added significant information once 2-hr glucose was in the models. In subjects with FPG <7.0 mmol/L and HbA1c < or = 6.5%, the HR was 1.35 (1.03-1.78) in men with 2-hr glucose > or = 7.8 mmol/L compared with men with 2-hr glucose <7.8 mmol/L.CONCLUSION: Elevated 2-hr glucose was a predictor of mortality independent of the levels of fasting glucose and HbA1c.

AB - OBJECTIVE: To quantify the relative contribution of elevated 2-hr glucose, fasting glucose (FPG), and HbA1c to all-cause mortality.STUDY DESIGN AND SETTING: A joint analysis of two prospective studies with baseline glycemia measurements.RESULTS: The multivariate adjusted hazard ratios (HRs) corresponding to a one standard deviation increase in HbA1c were 1.14 (95% CI 1.03-1.25), 1.08 (0.98-1.19) for FPG and 1.15 (1.05-1.27) for 2-hr glucose, respectively. Entering the 2-hr glucose to the model based on the FPG and HbA1c significantly improved the prediction of mortality, whereas neither FPG, nor HbA1c added significant information once 2-hr glucose was in the models. In subjects with FPG <7.0 mmol/L and HbA1c < or = 6.5%, the HR was 1.35 (1.03-1.78) in men with 2-hr glucose > or = 7.8 mmol/L compared with men with 2-hr glucose <7.8 mmol/L.CONCLUSION: Elevated 2-hr glucose was a predictor of mortality independent of the levels of fasting glucose and HbA1c.

KW - Aged

KW - Aged, 80 and over

KW - Blood Glucose

KW - Cause of Death

KW - Diabetes Mellitus

KW - Fasting

KW - Glucose Tolerance Test

KW - Glycated Hemoglobin A

KW - Humans

KW - Male

KW - Middle Aged

KW - Predictive Value of Tests

KW - Proportional Hazards Models

KW - Prospective Studies

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

KW - Research Support, U.S. Gov't, P.H.S.

U2 - 10.1016/j.jclinepi.2003.10.007

DO - 10.1016/j.jclinepi.2003.10.007

M3 - Article

C2 - 15246127

SN - 0895-4356

VL - 57

SP - 590

EP - 596

JO - Journal of Clinical Epidemiology

JF - Journal of Clinical Epidemiology

IS - 6

ER -

Two prospective studies found that elevated 2-hr glucose predicted male mortality independent of fasting glucose and HbA1c

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