Type VII secretion-mycobacteria show the way.

A.M. Abdallah, N.C. Gey van Pittius, P.A. Champion, J. Cox, S. Luirink, C.M.J.E. Vandenbroucke-Grauls, B.J. Appelmelk, W. Bitter

Research output: Contribution to JournalArticleAcademic

Abstract

Recent evidence shows that mycobacteria have developed novel and specialized secretion systems for the transport of extracellular proteins across their hydrophobic, and highly impermeable, cell wall. Strikingly, mycobacterial genomes encode up to five of these transport systems. Two of these systems, ESX-1 and ESX-5, are involved in virulence - they both affect the cell-to-cell migration of pathogenic mycobacteria. Here, we discuss this novel secretion pathway and consider variants that are present in various Gram-positive bacteria. Given the unique composition of this secretion system, and its general importance, we propose that, in line with the accepted nomenclature, it should be called type VII secretion.
Original languageEnglish
Pages (from-to)883-891
JournalNature Reviews Microbiology
Volume5
Issue number11
DOIs
Publication statusPublished - 2007

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Mycobacterium
Secretory Pathway
Gram-Positive Bacteria
Terminology
Cell Wall
Cell Movement
Virulence
Carrier Proteins
Genome

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Abdallah, A. M., Gey van Pittius, N. C., Champion, P. A., Cox, J., Luirink, S., Vandenbroucke-Grauls, C. M. J. E., ... Bitter, W. (2007). Type VII secretion-mycobacteria show the way. Nature Reviews Microbiology, 5(11), 883-891. https://doi.org/10.1038/nrmicro1773
Abdallah, A.M. ; Gey van Pittius, N.C. ; Champion, P.A. ; Cox, J. ; Luirink, S. ; Vandenbroucke-Grauls, C.M.J.E. ; Appelmelk, B.J. ; Bitter, W. / Type VII secretion-mycobacteria show the way. In: Nature Reviews Microbiology. 2007 ; Vol. 5, No. 11. pp. 883-891.
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Abdallah, AM, Gey van Pittius, NC, Champion, PA, Cox, J, Luirink, S, Vandenbroucke-Grauls, CMJE, Appelmelk, BJ & Bitter, W 2007, 'Type VII secretion-mycobacteria show the way.' Nature Reviews Microbiology, vol. 5, no. 11, pp. 883-891. https://doi.org/10.1038/nrmicro1773

Type VII secretion-mycobacteria show the way. / Abdallah, A.M.; Gey van Pittius, N.C.; Champion, P.A.; Cox, J.; Luirink, S.; Vandenbroucke-Grauls, C.M.J.E.; Appelmelk, B.J.; Bitter, W.

In: Nature Reviews Microbiology, Vol. 5, No. 11, 2007, p. 883-891.

Research output: Contribution to JournalArticleAcademic

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Abdallah AM, Gey van Pittius NC, Champion PA, Cox J, Luirink S, Vandenbroucke-Grauls CMJE et al. Type VII secretion-mycobacteria show the way. Nature Reviews Microbiology. 2007;5(11):883-891. https://doi.org/10.1038/nrmicro1773