Ubiquitination of CXCR7 controls receptor trafficking

M. Canals; D.J. Scholten; S.M. de Munnik; M.K.L. Han; M.J. Smit; R. Leurs

doi:10.1371/journal.pone.0034192

Ubiquitination of CXCR7 controls receptor trafficking

M. Canals, D.J. Scholten, S.M. de Munnik, M.K.L. Han, M.J. Smit, R. Leurs

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Abstract

The chemokine receptor CXCR7 binds CXCL11 and CXCL12 with high affinity, chemokines that were previously thought to bind exclusively to CXCR4 and CXCR3, respectively. Expression of CXCR7 has been associated with cardiac development as well as with tumor growth and progression. Despite having all the canonical features of G protein-coupled receptors (GPCRs), the signalling pathways following CXCR7 activation remain controversial, since unlike typical chemokine receptors, CXCR7 fails to activate Gα

Original language	English
Pages (from-to)	e34192
Journal	PLoS ONE
Volume	7
DOIs	https://doi.org/10.1371/journal.pone.0034192
Publication status	Published - 2012

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title = "Ubiquitination of CXCR7 controls receptor trafficking",

abstract = "The chemokine receptor CXCR7 binds CXCL11 and CXCL12 with high affinity, chemokines that were previously thought to bind exclusively to CXCR4 and CXCR3, respectively. Expression of CXCR7 has been associated with cardiac development as well as with tumor growth and progression. Despite having all the canonical features of G protein-coupled receptors (GPCRs), the signalling pathways following CXCR7 activation remain controversial, since unlike typical chemokine receptors, CXCR7 fails to activate Gα",

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AU - Canals, M.

AU - Scholten, D.J.

AU - de Munnik, S.M.

AU - Han, M.K.L.

AU - Smit, M.J.

AU - Leurs, R.

PY - 2012

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AB - The chemokine receptor CXCR7 binds CXCL11 and CXCL12 with high affinity, chemokines that were previously thought to bind exclusively to CXCR4 and CXCR3, respectively. Expression of CXCR7 has been associated with cardiac development as well as with tumor growth and progression. Despite having all the canonical features of G protein-coupled receptors (GPCRs), the signalling pathways following CXCR7 activation remain controversial, since unlike typical chemokine receptors, CXCR7 fails to activate Gα

U2 - 10.1371/journal.pone.0034192

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SN - 1932-6203

VL - 7

SP - e34192

JO - PLoS ONE

JF - PLoS ONE

ER -

Ubiquitination of CXCR7 controls receptor trafficking

Abstract

UN SDGs

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