Ubiquitination of CXCR7 controls receptor trafficking

M. Canals, D.J. Scholten, S.M. de Munnik, M.K.L. Han, M.J. Smit, R. Leurs

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

The chemokine receptor CXCR7 binds CXCL11 and CXCL12 with high affinity, chemokines that were previously thought to bind exclusively to CXCR4 and CXCR3, respectively. Expression of CXCR7 has been associated with cardiac development as well as with tumor growth and progression. Despite having all the canonical features of G protein-coupled receptors (GPCRs), the signalling pathways following CXCR7 activation remain controversial, since unlike typical chemokine receptors, CXCR7 fails to activate Gα
Original languageEnglish
Pages (from-to)e34192
JournalPLoS ONE
Volume7
DOIs
Publication statusPublished - 2012

Fingerprint

Chemokine Receptors
Ubiquitination
receptors
chemokines
G-Protein-Coupled Receptors
Chemokines
Tumors
Chemical activation
neoplasms
Growth
Neoplasms
ubiquitination
chemokine receptors
G-protein coupled receptors

Cite this

Canals, M. ; Scholten, D.J. ; de Munnik, S.M. ; Han, M.K.L. ; Smit, M.J. ; Leurs, R. / Ubiquitination of CXCR7 controls receptor trafficking. In: PLoS ONE. 2012 ; Vol. 7. pp. e34192.
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author = "M. Canals and D.J. Scholten and {de Munnik}, S.M. and M.K.L. Han and M.J. Smit and R. Leurs",
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Ubiquitination of CXCR7 controls receptor trafficking. / Canals, M.; Scholten, D.J.; de Munnik, S.M.; Han, M.K.L.; Smit, M.J.; Leurs, R.

In: PLoS ONE, Vol. 7, 2012, p. e34192.

Research output: Contribution to JournalArticleAcademicpeer-review

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AU - Canals, M.

AU - Scholten, D.J.

AU - de Munnik, S.M.

AU - Han, M.K.L.

AU - Smit, M.J.

AU - Leurs, R.

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AB - The chemokine receptor CXCR7 binds CXCL11 and CXCL12 with high affinity, chemokines that were previously thought to bind exclusively to CXCR4 and CXCR3, respectively. Expression of CXCR7 has been associated with cardiac development as well as with tumor growth and progression. Despite having all the canonical features of G protein-coupled receptors (GPCRs), the signalling pathways following CXCR7 activation remain controversial, since unlike typical chemokine receptors, CXCR7 fails to activate Gα

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M3 - Article

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SP - e34192

JO - PLoS ONE

JF - PLoS ONE

SN - 1932-6203

ER -