Ubiquitination of CXCR7 controls receptor trafficking

M. Canals, D.J. Scholten, S.M. de Munnik, M.K.L. Han, M.J. Smit, R. Leurs

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The chemokine receptor CXCR7 binds CXCL11 and CXCL12 with high affinity, chemokines that were previously thought to bind exclusively to CXCR4 and CXCR3, respectively. Expression of CXCR7 has been associated with cardiac development as well as with tumor growth and progression. Despite having all the canonical features of G protein-coupled receptors (GPCRs), the signalling pathways following CXCR7 activation remain controversial, since unlike typical chemokine receptors, CXCR7 fails to activate Gα
Original languageEnglish
Pages (from-to)e34192
JournalPLoS ONE
Publication statusPublished - 2012


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