Abstract
We report the synthesis of racetams, a diverse class of small molecule drugs, by means of the Ugi four-center three-component reaction (U4C-3CR). For the first time, γ-aminobutyric acid is employed as bifunctional input in the Ugi reaction. This protocol is simple, general, and allows one-pot access to a range of drugs and bioactive small molecules.
Original language | English |
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Article number | ss-2016-t0732-op |
Pages (from-to) | 1664-1674 |
Number of pages | 11 |
Journal | Synthesis |
Volume | 49 |
Issue number | 7 |
Early online date | 16 Dec 2016 |
DOIs | |
Publication status | Published - Apr 2017 |
Keywords
- Ugi reaction
- medicinal chemistry
- multicomponent reactions
- pyrrolidones
- racetams