Ugi Four-Center Three-Component Reaction as a Direct Approach to Racetams

Razvan C. Cioc, Lola Schaepkens van Riempst, Peter Schuckman, Eelco Ruijter, Romano V. A. Orru

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We report the synthesis of racetams, a diverse class of small molecule drugs, by means of the Ugi four-center three-component reaction (U4C-3CR). For the first time, γ-aminobutyric acid is employed as bifunctional input in the Ugi reaction. This protocol is simple, general, and allows one-pot access to a range of drugs and bioactive small molecules.

Original languageEnglish
Article numberss-2016-t0732-op
Pages (from-to)1664-1674
Number of pages11
Issue number7
Early online date16 Dec 2016
Publication statusPublished - Apr 2017


  • Ugi reaction
  • medicinal chemistry
  • multicomponent reactions
  • pyrrolidones
  • racetams


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