Ugi-Type Reactions of Spirocyclic Indolenines as a Platform for Compound Library Generation

Veronica Estevez, Laura Kloeters, Natalia Kwietniewska, Esther Vicente-Garcia, Eelco Ruijter, Romano V. A. Orru

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

A simple and efficient method for the synthesis of highly substituted spiroindoline derivatives is presented. A Fischer indolization is combined with Ugi-type reactions to explore the chemical space concerning this privileged structure. Moreover, spiropiperidine derivatives could be postmodified for the production of a small-molecule library that will be part of the Joint European Compound Library of the European Lead Factory.

Original languageEnglish
Article numberst-2016-d0595-l
Pages (from-to)376-380
Number of pages5
JournalSynlett
Volume28
Issue number3
DOIs
Publication statusPublished - Feb 2017

Keywords

  • Ugi-type reaction
  • compound library
  • scaffold
  • spiroindoline

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