Ugi-Type Reactions of Spirocyclic Indolenines as a Platform for Compound Library Generation

Veronica Estevez; Laura Kloeters; Natalia Kwietniewska; Esther Vicente-Garcia; Eelco Ruijter; Romano V. A. Orru

doi:10.1055/s-0036-1588084

Ugi-Type Reactions of Spirocyclic Indolenines as a Platform for Compound Library Generation

Veronica Estevez, Laura Kloeters, Natalia Kwietniewska, Esther Vicente-Garcia, Eelco Ruijter, Romano V. A. Orru

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Abstract

A simple and efficient method for the synthesis of highly substituted spiroindoline derivatives is presented. A Fischer indolization is combined with Ugi-type reactions to explore the chemical space concerning this privileged structure. Moreover, spiropiperidine derivatives could be postmodified for the production of a small-molecule library that will be part of the Joint European Compound Library of the European Lead Factory.

Original language	English
Article number	st-2016-d0595-l
Pages (from-to)	376-380
Number of pages	5
Journal	Synlett
Volume	28
Issue number	3
Early online date	20 Oct 2016
DOIs	https://doi.org/10.1055/s-0036-1588084
Publication status	Published - Feb 2017

Keywords

Ugi-type reaction
compound library
scaffold
spiroindoline

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10.1055/s-0036-1588084

Ugi-Type Reactions of Spirocyclic Indolenines as a Platform for Compound Library GenerationFinal published version, 197 KBLicence: Article 25fa Dutch Copyright Act

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AU - Estevez, Veronica

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AU - Vicente-Garcia, Esther

AU - Ruijter, Eelco

AU - Orru, Romano V. A.

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AB - A simple and efficient method for the synthesis of highly substituted spiroindoline derivatives is presented. A Fischer indolization is combined with Ugi-type reactions to explore the chemical space concerning this privileged structure. Moreover, spiropiperidine derivatives could be postmodified for the production of a small-molecule library that will be part of the Joint European Compound Library of the European Lead Factory.

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Ugi-Type Reactions of Spirocyclic Indolenines as a Platform for Compound Library Generation

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Keywords

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