Ultra-high field MRI: Advancing systems neuroscience towards mesoscopic human brain function

Serge O. Dumoulin*, Alessio Fracasso, Wietske van der Zwaag, Jeroen C.W. Siero, Natalia Petridou

*Corresponding author for this work

Research output: Contribution to JournalArticleAcademicpeer-review

176 Downloads (Pure)

Abstract

Human MRI scanners at ultra-high magnetic field strengths of 7 T and higher are increasingly available to the neuroscience community. A key advantage brought by ultra-high field MRI is the possibility to increase the spatial resolution at which data is acquired, with little reduction in image quality. This opens a new set of opportunities for neuroscience, allowing investigators to map the human cortex at an unprecedented level of detail. In this review, we present recent work that capitalizes on the increased signal-to-noise ratio available at ultra-high field and discuss the theoretical advances with a focus on sensory and motor systems neuroscience. Further, we review research performed at sub-millimeter spatial resolution and discuss the limits and the potential of ultra-high field imaging for structural and functional imaging in human cortex. The increased spatial resolution achievable at ultra-high field has the potential to unveil the fundamental computations performed within a given cortical area, ultimately allowing the visualization of the mesoscopic organization of human cortex at the functional and structural level.

Original languageEnglish
Pages (from-to)345-357
Number of pages13
JournalNeuroImage
Volume168
Early online date16 Jan 2017
DOIs
Publication statusPublished - Mar 2018

Bibliographical note

Funding Information:
This work has supported by the European Union's Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement No 641805 (S.D.), Ammodo KNAW Award (S.D.) and a Netherlands Organization for Scientific Research (NWO) Vidi Grant 13339 (N.P.). The Spinoza Centre is a joint initiative of the University of Amsterdam, Academic Medical Center, VU University, VU University Medical Center, Netherlands Institute for Neuroscience and the Royal Netherlands Academy of Sciences.

Funding Information:
This work has supported by the European Union's Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement No 641805 (S.D.), Ammodo KNAW Award (S.D.) and a Netherlands Organization for Scientific Research (NWO) Vidi Grant 13339 (N.P.). The Spinoza Centre is a joint initiative of the University of Amsterdam, Academic Medical Center, VU University, VU University Medical Center, Netherlands Institute for Neuroscience and the Royal Netherlands Academy of Sciences.

Publisher Copyright:
© 2017 Elsevier Inc.

Copyright:
Copyright 2019 Elsevier B.V., All rights reserved.

Funding

This work has supported by the European Union's Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement No 641805 (S.D.), Ammodo KNAW Award (S.D.) and a Netherlands Organization for Scientific Research (NWO) Vidi Grant 13339 (N.P.). The Spinoza Centre is a joint initiative of the University of Amsterdam, Academic Medical Center, VU University, VU University Medical Center, Netherlands Institute for Neuroscience and the Royal Netherlands Academy of Sciences. This work has supported by the European Union's Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement No 641805 (S.D.), Ammodo KNAW Award (S.D.) and a Netherlands Organization for Scientific Research (NWO) Vidi Grant 13339 (N.P.). The Spinoza Centre is a joint initiative of the University of Amsterdam, Academic Medical Center, VU University, VU University Medical Center, Netherlands Institute for Neuroscience and the Royal Netherlands Academy of Sciences.

Keywords

  • 7 T
  • Cortical organization
  • Cortical processing unit
  • Hypercolumn
  • MRI
  • Ultra-high field

Fingerprint

Dive into the research topics of 'Ultra-high field MRI: Advancing systems neuroscience towards mesoscopic human brain function'. Together they form a unique fingerprint.

Cite this