Ultra-sparse Connectivity within the Lateral Hypothalamus

Denis Burdakov; Mahesh M. Karnani

doi:10.1016/j.cub.2020.07.061

Ultra-sparse Connectivity within the Lateral Hypothalamus

Denis Burdakov, Mahesh M. Karnani^*

^*Corresponding author for this work

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

It is unknown how neural activity is coordinated among lateral hypothalamic area (LH) neurons, which generate fundamental behavioral actions such as attack and evasion. Burdakov and Karnani show there is near-zero local connectivity in the LH, suggesting that incoming synaptic input is integrated primarily within individual neurons.

Original language	English
Pages (from-to)	4063-4070.e2
Journal	Current Biology
Volume	30
Issue number	20
DOIs	https://doi.org/10.1016/j.cub.2020.07.061
Publication status	Accepted/In press - 1 Jan 2020
Externally published	Yes

Funding

We thank Jesse Jackson, Rebecca Jordan, Han-Tao Li, Karri Lämsä, and three anonymous referees for helpful comments and discussion. This project has received funding from the European Union's Horizon 2020 research and innovation program under Marie Skłodowska-Curie grant agreement DRIVOME (701986). This work was funded by The Francis Crick Institute, which receives its core funding from Cancer Research UK (FC001055), the UK Medical Research Council (FC001055), and the Wellcome Trust (FC001055). Conceptualization, M.M.K.; Methodology, M.M.K.; Software, M.M.K.; Analysis, M.M.K.; Investigation, M.M.K.; Resources, D.B.; Writing – Original Draft, M.M.K.; Writing – Review & Editing, M.M.K. and D.B.; Funding Acquisition, M.M.K. and D.B. The authors declare no competing interests. We thank Jesse Jackson, Rebecca Jordan, Han-Tao Li, Karri Lämsä, and three anonymous referees for helpful comments and discussion. This project has received funding from the European Union ’s Horizon 2020 research and innovation program under Marie Skłodowska-Curie grant agreement DRIVOME ( 701986 ). This work was funded by The Francis Crick Institute , which receives its core funding from Cancer Research UK ( FC001055 ), the UK Medical Research Council ( FC001055 ), and the Wellcome Trust ( FC001055 ).

Funders	Funder number
DRIVOME
European Union ’s Horizon 2020 research and innovation program
Jesse Jackson
Wellcome Trust
Francis Crick Institute
Horizon 2020 Framework Programme	701986
Medical Research Council
Cancer Research UK	FC001055
Horizon 2020

Keywords

gamma oscillation
lateral hypothalamus
MCH
orexin
patch clamp
synaptic connectivity

Access to Document

10.1016/j.cub.2020.07.061

Persistent URL (handle)

Persistent link

Cite this

@article{3929bb231d884c62b53080d662c27ea3,

title = "Ultra-sparse Connectivity within the Lateral Hypothalamus",

abstract = "It is unknown how neural activity is coordinated among lateral hypothalamic area (LH) neurons, which generate fundamental behavioral actions such as attack and evasion. Burdakov and Karnani show there is near-zero local connectivity in the LH, suggesting that incoming synaptic input is integrated primarily within individual neurons.",

keywords = "gamma oscillation, lateral hypothalamus, MCH, orexin, patch clamp, synaptic connectivity",

author = "Denis Burdakov and Karnani, {Mahesh M.}",

year = "2020",

month = jan,

day = "1",

doi = "10.1016/j.cub.2020.07.061",

language = "English",

volume = "30",

pages = "4063--4070.e2",

journal = "Current Biology",

issn = "0960-9822",

publisher = "Cell Press",

number = "20",

}

TY - JOUR

T1 - Ultra-sparse Connectivity within the Lateral Hypothalamus

AU - Burdakov, Denis

AU - Karnani, Mahesh M.

PY - 2020/1/1

Y1 - 2020/1/1

N2 - It is unknown how neural activity is coordinated among lateral hypothalamic area (LH) neurons, which generate fundamental behavioral actions such as attack and evasion. Burdakov and Karnani show there is near-zero local connectivity in the LH, suggesting that incoming synaptic input is integrated primarily within individual neurons.

AB - It is unknown how neural activity is coordinated among lateral hypothalamic area (LH) neurons, which generate fundamental behavioral actions such as attack and evasion. Burdakov and Karnani show there is near-zero local connectivity in the LH, suggesting that incoming synaptic input is integrated primarily within individual neurons.

KW - gamma oscillation

KW - lateral hypothalamus

KW - MCH

KW - orexin

KW - patch clamp

KW - synaptic connectivity

UR - http://www.scopus.com/inward/record.url?scp=85090187612&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85090187612&partnerID=8YFLogxK

U2 - 10.1016/j.cub.2020.07.061

DO - 10.1016/j.cub.2020.07.061

M3 - Article

AN - SCOPUS:85090187612

SN - 0960-9822

VL - 30

SP - 4063-4070.e2

JO - Current Biology

JF - Current Biology

IS - 20

ER -

Ultra-sparse Connectivity within the Lateral Hypothalamus

Abstract

Funding

Keywords

Access to Document

Persistent URL (handle)

Other files and links

Fingerprint

Cite this