Ultra-sparse Connectivity within the Lateral Hypothalamus

Denis Burdakov, Mahesh M. Karnani*

*Corresponding author for this work

Research output: Contribution to JournalArticleAcademicpeer-review


It is unknown how neural activity is coordinated among lateral hypothalamic area (LH) neurons, which generate fundamental behavioral actions such as attack and evasion. Burdakov and Karnani show there is near-zero local connectivity in the LH, suggesting that incoming synaptic input is integrated primarily within individual neurons.

Original languageEnglish
Pages (from-to)4063-4070.e2
JournalCurrent Biology
Issue number20
Publication statusAccepted/In press - 1 Jan 2020
Externally publishedYes


  • gamma oscillation
  • lateral hypothalamus
  • MCH
  • orexin
  • patch clamp
  • synaptic connectivity


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