Ultra-sparse Connectivity within the Lateral Hypothalamus

Denis Burdakov, Mahesh M. Karnani*

*Corresponding author for this work

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

It is unknown how neural activity is coordinated among lateral hypothalamic area (LH) neurons, which generate fundamental behavioral actions such as attack and evasion. Burdakov and Karnani show there is near-zero local connectivity in the LH, suggesting that incoming synaptic input is integrated primarily within individual neurons.

Original languageEnglish
Pages (from-to)4063-4070.e2
JournalCurrent Biology
Volume30
Issue number20
DOIs
Publication statusAccepted/In press - 1 Jan 2020
Externally publishedYes

Funding

We thank Jesse Jackson, Rebecca Jordan, Han-Tao Li, Karri Lämsä, and three anonymous referees for helpful comments and discussion. This project has received funding from the European Union's Horizon 2020 research and innovation program under Marie Skłodowska-Curie grant agreement DRIVOME (701986). This work was funded by The Francis Crick Institute, which receives its core funding from Cancer Research UK (FC001055), the UK Medical Research Council (FC001055), and the Wellcome Trust (FC001055). Conceptualization, M.M.K.; Methodology, M.M.K.; Software, M.M.K.; Analysis, M.M.K.; Investigation, M.M.K.; Resources, D.B.; Writing – Original Draft, M.M.K.; Writing – Review & Editing, M.M.K. and D.B.; Funding Acquisition, M.M.K. and D.B. The authors declare no competing interests. We thank Jesse Jackson, Rebecca Jordan, Han-Tao Li, Karri Lämsä, and three anonymous referees for helpful comments and discussion. This project has received funding from the European Union ’s Horizon 2020 research and innovation program under Marie Skłodowska-Curie grant agreement DRIVOME ( 701986 ). This work was funded by The Francis Crick Institute , which receives its core funding from Cancer Research UK ( FC001055 ), the UK Medical Research Council ( FC001055 ), and the Wellcome Trust ( FC001055 ).

FundersFunder number
DRIVOME
European Union ’s Horizon 2020 research and innovation program
Jesse Jackson
Wellcome Trust
Francis Crick Institute
Horizon 2020 Framework Programme701986
Medical Research Council
Cancer Research UKFC001055
Horizon 2020

    Keywords

    • gamma oscillation
    • lateral hypothalamus
    • MCH
    • orexin
    • patch clamp
    • synaptic connectivity

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