Understanding specificity of the mycosin proteases in ESX/type VII secretion by structural and functional analysis

J.M. Wagner; T.J. Evans; J. Chen; H.N. Zhu; E.N.G. Houben; W. Bitter; K.V. Korotkov

doi:10.1016/j.jsb.2013.09.022

Understanding specificity of the mycosin proteases in ESX/type VII secretion by structural and functional analysis

J.M. Wagner, T.J. Evans, J. Chen, H.N. Zhu, E.N.G. Houben, W. Bitter, K.V. Korotkov

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Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

Mycobacteria use specialized ESX secretion systems to transport proteins across their cell membranes in order to manipulate their environment. In pathogenic Mycobacterium tuberculosis there are five paralogous ESX secretion systems, named ESX-1 through ESX-5. Each system includes a subtilisin-like protease (mycosin or MycP) as a core component essential for secretion. Here we report crystal structures of MycP

Original language	English
Pages (from-to)	115-128
Journal	Journal of Structural Biology
Volume	184
Issue number	2
DOIs	https://doi.org/10.1016/j.jsb.2013.09.022
Publication status	Published - 2013

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10.1016/j.jsb.2013.09.022

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title = "Understanding specificity of the mycosin proteases in ESX/type VII secretion by structural and functional analysis",

abstract = "Mycobacteria use specialized ESX secretion systems to transport proteins across their cell membranes in order to manipulate their environment. In pathogenic Mycobacterium tuberculosis there are five paralogous ESX secretion systems, named ESX-1 through ESX-5. Each system includes a subtilisin-like protease (mycosin or MycP) as a core component essential for secretion. Here we report crystal structures of MycP",

author = "J.M. Wagner and T.J. Evans and J. Chen and H.N. Zhu and E.N.G. Houben and W. Bitter and K.V. Korotkov",

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journal = "Journal of Structural Biology",

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T1 - Understanding specificity of the mycosin proteases in ESX/type VII secretion by structural and functional analysis

AU - Wagner, J.M.

AU - Evans, T.J.

AU - Chen, J.

AU - Zhu, H.N.

AU - Houben, E.N.G.

AU - Bitter, W.

AU - Korotkov, K.V.

PY - 2013

Y1 - 2013

N2 - Mycobacteria use specialized ESX secretion systems to transport proteins across their cell membranes in order to manipulate their environment. In pathogenic Mycobacterium tuberculosis there are five paralogous ESX secretion systems, named ESX-1 through ESX-5. Each system includes a subtilisin-like protease (mycosin or MycP) as a core component essential for secretion. Here we report crystal structures of MycP

AB - Mycobacteria use specialized ESX secretion systems to transport proteins across their cell membranes in order to manipulate their environment. In pathogenic Mycobacterium tuberculosis there are five paralogous ESX secretion systems, named ESX-1 through ESX-5. Each system includes a subtilisin-like protease (mycosin or MycP) as a core component essential for secretion. Here we report crystal structures of MycP

U2 - 10.1016/j.jsb.2013.09.022

DO - 10.1016/j.jsb.2013.09.022

M3 - Article

SN - 1047-8477

VL - 184

SP - 115

EP - 128

JO - Journal of Structural Biology

JF - Journal of Structural Biology

IS - 2

ER -

Understanding specificity of the mycosin proteases in ESX/type VII secretion by structural and functional analysis

Abstract

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