TY - JOUR
T1 - Unfolded protein response activates glycogen synthase kinase-3 via selective lysosomal degradation
AU - Nijholt, D.A.T.
AU - Nolle, A.
AU - van Haastert, E.S.
AU - Edelijn, H.
AU - Toonen, R.F.G.
AU - Hoozemans, J.J.M.
AU - Scheper, W.
PY - 2013
Y1 - 2013
N2 - The unfolded protein response (UPR) is a stress response that is activated upon disturbed homeostasis in the endoplasmic reticulum. In Alzheimer's disease, as well as in other tauopathies, the UPR is activated in neurons that contain early tau pathology. A recent genome-wide association study identified genetic variation in a UPR transducer as a risk factor for tauopathy, supporting a functional connection between UPR activation and tau pathology. Here we show that UPR activation increases the activity of the major tau kinase glycogen synthase kinase (GSK)-3 in vitro via a selective removal of inactive GSK-3 phosphorylated at Ser
AB - The unfolded protein response (UPR) is a stress response that is activated upon disturbed homeostasis in the endoplasmic reticulum. In Alzheimer's disease, as well as in other tauopathies, the UPR is activated in neurons that contain early tau pathology. A recent genome-wide association study identified genetic variation in a UPR transducer as a risk factor for tauopathy, supporting a functional connection between UPR activation and tau pathology. Here we show that UPR activation increases the activity of the major tau kinase glycogen synthase kinase (GSK)-3 in vitro via a selective removal of inactive GSK-3 phosphorylated at Ser
UR - https://www.scopus.com/pages/publications/84875855976
UR - https://www.scopus.com/inward/citedby.url?scp=84875855976&partnerID=8YFLogxK
U2 - 10.1016/j.neurobiolaging.2013.01.008
DO - 10.1016/j.neurobiolaging.2013.01.008
M3 - Article
SN - 0197-4580
VL - 34
SP - 1759
EP - 1771
JO - Neurobiology of Aging
JF - Neurobiology of Aging
IS - 7
ER -
