Use cases, best practice and reporting standards for metabolomics in regulatory toxicology

Mark R. Viant; Timothy M.D. Ebbels; Richard D. Beger; Drew R. Ekman; David J.T. Epps; Hennicke Kamp; Pim E.G. Leonards; George D. Loizou; James I. MacRae; Bennard van Ravenzwaay; Philippe Rocca-Serra; Reza M. Salek; Tilmann Walk; Ralf J.M. Weber

doi:10.1038/s41467-019-10900-y

Use cases, best practice and reporting standards for metabolomics in regulatory toxicology

Mark R. Viant^*, Timothy M.D. Ebbels, Richard D. Beger, Drew R. Ekman, David J.T. Epps, Hennicke Kamp, Pim E.G. Leonards, George D. Loizou, James I. MacRae, Bennard van Ravenzwaay, Philippe Rocca-Serra, Reza M. Salek, Tilmann Walk, Ralf J.M. Weber

^*Corresponding author for this work

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

Lack of best practice guidelines currently limits the application of metabolomics in the regulatory sciences. Here, the MEtabolomics standaRds Initiative in Toxicology (MERIT) proposes methods and reporting standards for several important applications of metabolomics in regulatory toxicology.

Original language	English
Article number	3041
Pages (from-to)	1-10
Number of pages	10
Journal	Nature Communications
Volume	10
DOIs	https://doi.org/10.1038/s41467-019-10900-y
Publication status	Published - 10 Jul 2019

Funding

The MERIT project brought together a team of international experts from industry, government agencies, regulators and academia from across Europe and the United States, including the US Environmental Protection Agency, US Food and Drug Administration, UK Health and Safety Executive, BASF, Imperial College London, University of Birmingham, VU University Amsterdam, The Francis Crick Institute, and the Metabolomics Society Data Standards Task Group. Following the development of a draft guidance document by the core team, it was opened to international consultation (again including a wide range of stakeholders). We thank the European Centre for Ecotoxicology and Toxicology of Chemicals (ECE-TOC) for financial support, and thank the following for comments received during the consultation phase of this paper: Masanori Arita, National Institute of Genetics, Japan; Adam Biales, EPA, USA; Saravanan Dayalan, Metabolomics Australia, Australia; Warwick Dunn, University of Birmingham, UK; Thomas Hartung, Johns Hopkins University, USA; Michael P. Mawn, Corteva Agriscience, Agriculture Division of DowDuPont, Haskell Global Centre for Health Sciences USA; Serge Rudaz, University of Geneva, University of Lausanne, Switzerland; Jinchun Sun, National Center for Toxicological Research (NCTR) USA; Fidele Tugizimana, University of Johannesburg, South Africa; Juan Antonio Vizcaino, EMBL-EBI, UK; Rosemary T. Zaleski, ExxonMobil Biomedical Sciences, USA; Krista A. Zanetti, National Cancer Institute, USA.

Funders	Funder number
DowDuPont
European Centre for Ecotoxicology and Toxicology of Chemicals
ExxonMobil Biomedical Sciences
Haskell Global Centre for Health Sciences USA
National Center for Toxicological Research
National Institute of Genetics, Japan
Serge Rudaz, University of Geneva
Thomas Hartung
National Cancer Institute
Johns Hopkins University
European Bioinformatics Institute
Université de Lausanne
University of Johannesburg

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Viant, M. R., Ebbels, T. M. D., Beger, R. D., Ekman, D. R., Epps, D. J. T., Kamp, H., Leonards, P. E. G., Loizou, G. D., MacRae, J. I., van Ravenzwaay, B., Rocca-Serra, P., Salek, R. M., Walk, T., & Weber, R. J. M. (2019). Use cases, best practice and reporting standards for metabolomics in regulatory toxicology. Nature Communications, 10, 1-10. Article 3041. https://doi.org/10.1038/s41467-019-10900-y

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Use cases, best practice and reporting standards for metabolomics in regulatory toxicology

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