Use cases, best practice and reporting standards for metabolomics in regulatory toxicology

Mark R. Viant; Timothy M.D. Ebbels; Richard D. Beger; Drew R. Ekman; David J.T. Epps; Hennicke Kamp; Pim E.G. Leonards; George D. Loizou; James I. MacRae; Bennard van Ravenzwaay; Philippe Rocca-Serra; Reza M. Salek; Tilmann Walk; Ralf J.M. Weber

doi:10.1038/s41467-019-10900-y

Use cases, best practice and reporting standards for metabolomics in regulatory toxicology

Mark R. Viant^*
, Timothy M.D. Ebbels
, Richard D. Beger
, Drew R. Ekman
, David J.T. Epps
, Hennicke Kamp
, Pim E.G. Leonards
, George D. Loizou
, James I. MacRae
, Bennard van Ravenzwaay
, Philippe Rocca-Serra
, Reza M. Salek
, Tilmann Walk
, Ralf J.M. Weber

^*Corresponding author for this work

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

Lack of best practice guidelines currently limits the application of metabolomics in the regulatory sciences. Here, the MEtabolomics standaRds Initiative in Toxicology (MERIT) proposes methods and reporting standards for several important applications of metabolomics in regulatory toxicology.

Original language	English
Article number	3041
Pages (from-to)	1-10
Number of pages	10
Journal	Nature Communications
Volume	10
Early online date	10 Jul 2019
DOIs	https://doi.org/10.1038/s41467-019-10900-y
Publication status	Published - 2019

Funding

We thank the European Centre for Ecotoxicology and Toxicology of Chemicals (ECE-TOC) for financial support, and thank the following for comments received during the consultation phase of this paper: Masanori Arita, National Institute of Genetics, Japan; Adam Biales, EPA, USA; Saravanan Dayalan, Metabolomics Australia, Australia; Warwick Dunn, University of Birmingham, UK; Thomas Hartung, Johns Hopkins University, USA; Michael P. Mawn, Corteva Agriscience, Agriculture Division of DowDuPont, Haskell Global Centre for Health Sciences USA; Serge Rudaz, University of Geneva, University of Lausanne, Switzerland; Jinchun Sun, National Center for Toxicological Research (NCTR) USA; Fidele Tugizimana, University of Johannesburg, South Africa; Juan Antonio Vizcaino, EMBL-EBI, UK; Rosemary T. Zaleski, ExxonMobil Biomedical Sciences, USA; Krista A. Zanetti, National Cancer Institute, USA.

Funders	Funder number
Thomas Hartung
National Center for Toxicological Research
ExxonMobil Biomedical Sciences
Université de Lausanne
Johns Hopkins University
Haskell Global Centre for Health Sciences USA
University of Johannesburg
National Institute of Genetics, Japan
National Cancer Institute
DowDuPont
European Bioinformatics Institute
European Centre for Ecotoxicology and Toxicology of Chemicals
Serge Rudaz, University of Geneva
Biotechnology and Biological Sciences Research Council	BB/L024101/1

Access to Document

10.1038/s41467-019-10900-y

Persistent URL (handle)

Persistent link

Cite this

Viant, M. R., Ebbels, T. M. D., Beger, R. D., Ekman, D. R., Epps, D. J. T., Kamp, H., Leonards, P. E. G., Loizou, G. D., MacRae, J. I., van Ravenzwaay, B., Rocca-Serra, P., Salek, R. M., Walk, T., & Weber, R. J. M. (2019). Use cases, best practice and reporting standards for metabolomics in regulatory toxicology. Nature Communications, 10, 1-10. Article 3041. https://doi.org/10.1038/s41467-019-10900-y

@article{4bad97b0ecac40dea88cb185707ac89f,

title = "Use cases, best practice and reporting standards for metabolomics in regulatory toxicology",

abstract = "Lack of best practice guidelines currently limits the application of metabolomics in the regulatory sciences. Here, the MEtabolomics standaRds Initiative in Toxicology (MERIT) proposes methods and reporting standards for several important applications of metabolomics in regulatory toxicology.",

author = "Viant, \{Mark R.\} and Ebbels, \{Timothy M.D.\} and Beger, \{Richard D.\} and Ekman, \{Drew R.\} and Epps, \{David J.T.\} and Hennicke Kamp and Leonards, \{Pim E.G.\} and Loizou, \{George D.\} and MacRae, \{James I.\} and \{van Ravenzwaay\}, Bennard and Philippe Rocca-Serra and Salek, \{Reza M.\} and Tilmann Walk and Weber, \{Ralf J.M.\}",

year = "2019",

doi = "10.1038/s41467-019-10900-y",

language = "English",

volume = "10",

pages = "1--10",

journal = "Nature Communications",

issn = "2041-1723",

publisher = "Nature Research",

}

TY - JOUR

T1 - Use cases, best practice and reporting standards for metabolomics in regulatory toxicology

AU - Viant, Mark R.

AU - Ebbels, Timothy M.D.

AU - Beger, Richard D.

AU - Ekman, Drew R.

AU - Epps, David J.T.

AU - Kamp, Hennicke

AU - Leonards, Pim E.G.

AU - Loizou, George D.

AU - MacRae, James I.

AU - van Ravenzwaay, Bennard

AU - Rocca-Serra, Philippe

AU - Salek, Reza M.

AU - Walk, Tilmann

AU - Weber, Ralf J.M.

PY - 2019

Y1 - 2019

N2 - Lack of best practice guidelines currently limits the application of metabolomics in the regulatory sciences. Here, the MEtabolomics standaRds Initiative in Toxicology (MERIT) proposes methods and reporting standards for several important applications of metabolomics in regulatory toxicology.

AB - Lack of best practice guidelines currently limits the application of metabolomics in the regulatory sciences. Here, the MEtabolomics standaRds Initiative in Toxicology (MERIT) proposes methods and reporting standards for several important applications of metabolomics in regulatory toxicology.

UR - https://www.scopus.com/pages/publications/85068898392

UR - https://www.scopus.com/pages/publications/85068898392#tab=citedBy

U2 - 10.1038/s41467-019-10900-y

DO - 10.1038/s41467-019-10900-y

M3 - Article

AN - SCOPUS:85068898392

SN - 2041-1723

VL - 10

SP - 1

EP - 10

JO - Nature Communications

JF - Nature Communications

M1 - 3041

ER -

Use cases, best practice and reporting standards for metabolomics in regulatory toxicology

Abstract

Funding

Access to Document

Persistent URL (handle)

Other files and links

Fingerprint

Cite this