Using a digital tool to detect early changes in everyday functioning in older adults: A pilot study of the Assessment of Smartphone Everyday Tasks (ASSET)

Mark A. Dubbelman; Tia C. Hall; Isabella M. Levesque; Kayden J. Mimmack; Sietske A. M. Sikkes; Shira H. Fischer; Dorene M. Rentz; Reisa A. Sperling; Kathryn V. Papp; Rebecca E. Amariglio; Gad A. Marshall

doi:10.1002/dad2.12506

Using a digital tool to detect early changes in everyday functioning in older adults: A pilot study of the Assessment of Smartphone Everyday Tasks (ASSET)

Mark A. Dubbelman
, Tia C. Hall
, Isabella M. Levesque
, Kayden J. Mimmack
, Sietske A. M. Sikkes
, Shira H. Fischer
, Dorene M. Rentz
, Reisa A. Sperling
, Kathryn V. Papp
, Rebecca E. Amariglio
, Gad A. Marshall

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

INTRODUCTION: To investigate the utility of a new digital tool for measuring everyday functioning in preclinical Alzheimer's disease, we piloted the Assessment of Smartphone Everyday Tasks (ASSET) application.

METHODS: Forty-six participants (50.3 ± 27.1 years; 67% female; 20 young unimpaired, 17 old unimpaired, 9 mildly cognitively impaired) completed ASSET 7 times. ASSET comprises two main tasks, simulating a Patient Portal and a Calendar. We assessed ASSET's internal consistency, test–retest reliability, and user experience.

RESULTS: ASSET main tasks correlated with each other (r = 0.75, 95% confidence interval [CI] = [0.58, 0.86]). Performance on ASSET's Patient Portal related to cognition (r = 0.64, 95% CI = [0.42, 0.79]) and observer ratings of everyday functioning (r = 0.57, 95% CI = [0.24, 0.79]). Test–retest reliability was good (intraclass correlation coefficient = 0.87, 95% CI = [0.77, 0.93]). Most participants rated their experience with ASSET neutrally or positively.

DISCUSSION: ASSET is a promising smartphone-based digital assessment of everyday functioning. Future studies may investigate its utility for early diagnosis and evaluation of treatment of Alzheimer's disease.

Original language	English
Article number	e12506
Pages (from-to)	1-10
Number of pages	10
Journal	Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
Volume	15
Issue number	4
Early online date	17 Dec 2023
DOIs	https://doi.org/10.1002/dad2.12506
Publication status	Published - Dec 2023

Funding

This work was supported by a grant from the NIH/NIA (R42 AG069629) and the Vettel Family and Polayes Family funds. We would also like to acknowledge the ADK Group, who was partner in the development of ASSET. M.A.D. received grant support from Alzheimer Nederland (WE.06‐2023‐02), paid to his institution. T.C.H., I.M.L., and K.J.M. report no relevant disclosures. S.A.M.S. research programs have been funded by ZonMW (#7330502051 and #73305095008) and Health∼Holland, Topsector Life Sciences & Health (LSHM19051, LSHM20084, LSHM22026‐SGF). S.A.M.S. provided consultancy services to Prothena Biosciences, Aribio, Cogstate, Biogen, Boehringer and Toyama. All funds are paid to her institution. S.H.F., D.M.R., R.A.S., K.V.P., and R.E.A. report no relevant disclosures. G.A.M. has received research salary support for serving as site principal investigator for clinical trials funded by Eisai Inc., Eli Lilly and Company, and Genentech. These relationships are not related to the content in the manuscript. This work was supported by a grant from the NIH/NIA (R42 AG069629) and the Vettel Family and Polayes Family funds. We would also like to acknowledge the ADK Group, who was partner in the development of ASSET. M.A.D. received grant support from Alzheimer Nederland (WE.06-2023-02), paid to his institution. T.C.H., I.M.L., and K.J.M. report no relevant disclosures. S.A.M.S. research programs have been funded by ZonMW (#7330502051 and #73305095008) and Health∼Holland, Topsector Life Sciences & Health (LSHM19051, LSHM20084, LSHM22026-SGF). S.A.M.S. provided consultancy services to Prothena Biosciences, Aribio, Cogstate, Biogen, Boehringer and Toyama. All funds are paid to her institution. S.H.F., D.M.R., R.A.S., K.V.P., and R.E.A. report no relevant disclosures. G.A.M. has received research salary support for serving as site principal investigator for clinical trials funded by Eisai Inc., Eli Lilly and Company, and Genentech. These relationships are not related to the content in the manuscript.

Funders	Funder number
Vettel Family and Polayes Family funds	WE.06‐2023‐02
National Institutes of Health
National Institute on Aging	R42 AG069629
Genentech
ZonMw	7330502051, 73305095008, LSHM19051, LSHM20084
Eisai
Alzheimer Nederland

Access to Document

10.1002/dad2.12506

Persistent URL (handle)

Persistent link

Cite this

Dubbelman, M. A., Hall, T. C., Levesque, I. M., Mimmack, K. J., Sikkes, S. A. M., Fischer, S. H., Rentz, D. M., Sperling, R. A., Papp, K. V., Amariglio, R. E., & Marshall, G. A. (2023). Using a digital tool to detect early changes in everyday functioning in older adults: A pilot study of the Assessment of Smartphone Everyday Tasks (ASSET). Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, 15(4), 1-10. Article e12506. https://doi.org/10.1002/dad2.12506

@article{710e1470deed4922bf84451079a5c71d,

title = "Using a digital tool to detect early changes in everyday functioning in older adults: A pilot study of the Assessment of Smartphone Everyday Tasks (ASSET)",

abstract = "INTRODUCTION: To investigate the utility of a new digital tool for measuring everyday functioning in preclinical Alzheimer's disease, we piloted the Assessment of Smartphone Everyday Tasks (ASSET) application. METHODS: Forty-six participants (50.3 ± 27.1 years; 67\% female; 20 young unimpaired, 17 old unimpaired, 9 mildly cognitively impaired) completed ASSET 7 times. ASSET comprises two main tasks, simulating a Patient Portal and a Calendar. We assessed ASSET's internal consistency, test–retest reliability, and user experience. RESULTS: ASSET main tasks correlated with each other (r = 0.75, 95\% confidence interval [CI] = [0.58, 0.86]). Performance on ASSET's Patient Portal related to cognition (r = 0.64, 95\% CI = [0.42, 0.79]) and observer ratings of everyday functioning (r = 0.57, 95\% CI = [0.24, 0.79]). Test–retest reliability was good (intraclass correlation coefficient = 0.87, 95\% CI = [0.77, 0.93]). Most participants rated their experience with ASSET neutrally or positively. DISCUSSION: ASSET is a promising smartphone-based digital assessment of everyday functioning. Future studies may investigate its utility for early diagnosis and evaluation of treatment of Alzheimer's disease.",

author = "Dubbelman, \{Mark A.\} and Hall, \{Tia C.\} and Levesque, \{Isabella M.\} and Mimmack, \{Kayden J.\} and Sikkes, \{Sietske A. M.\} and Fischer, \{Shira H.\} and Rentz, \{Dorene M.\} and Sperling, \{Reisa A.\} and Papp, \{Kathryn V.\} and Amariglio, \{Rebecca E.\} and Marshall, \{Gad A.\}",

year = "2023",

month = dec,

doi = "10.1002/dad2.12506",

language = "English",

volume = "15",

pages = "1--10",

journal = "Alzheimer's \& Dementia: Diagnosis, Assessment \& Disease Monitoring",

issn = "2352-8729",

publisher = "John Wiley and Sons Inc.",

number = "4",

}

Dubbelman, MA, Hall, TC, Levesque, IM, Mimmack, KJ, Sikkes, SAM, Fischer, SH, Rentz, DM, Sperling, RA, Papp, KV, Amariglio, RE & Marshall, GA 2023, 'Using a digital tool to detect early changes in everyday functioning in older adults: A pilot study of the Assessment of Smartphone Everyday Tasks (ASSET)', Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, vol. 15, no. 4, e12506, pp. 1-10. https://doi.org/10.1002/dad2.12506

Using a digital tool to detect early changes in everyday functioning in older adults: A pilot study of the Assessment of Smartphone Everyday Tasks (ASSET). / Dubbelman, Mark A.; Hall, Tia C.; Levesque, Isabella M. et al.
In: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol. 15, No. 4, e12506, 12.2023, p. 1-10.

Research output: Contribution to Journal › Article › Academic › peer-review

TY - JOUR

T1 - Using a digital tool to detect early changes in everyday functioning in older adults

T2 - A pilot study of the Assessment of Smartphone Everyday Tasks (ASSET)

AU - Dubbelman, Mark A.

AU - Hall, Tia C.

AU - Levesque, Isabella M.

AU - Mimmack, Kayden J.

AU - Sikkes, Sietske A. M.

AU - Fischer, Shira H.

AU - Rentz, Dorene M.

AU - Sperling, Reisa A.

AU - Papp, Kathryn V.

AU - Amariglio, Rebecca E.

AU - Marshall, Gad A.

PY - 2023/12

Y1 - 2023/12

N2 - INTRODUCTION: To investigate the utility of a new digital tool for measuring everyday functioning in preclinical Alzheimer's disease, we piloted the Assessment of Smartphone Everyday Tasks (ASSET) application. METHODS: Forty-six participants (50.3 ± 27.1 years; 67% female; 20 young unimpaired, 17 old unimpaired, 9 mildly cognitively impaired) completed ASSET 7 times. ASSET comprises two main tasks, simulating a Patient Portal and a Calendar. We assessed ASSET's internal consistency, test–retest reliability, and user experience. RESULTS: ASSET main tasks correlated with each other (r = 0.75, 95% confidence interval [CI] = [0.58, 0.86]). Performance on ASSET's Patient Portal related to cognition (r = 0.64, 95% CI = [0.42, 0.79]) and observer ratings of everyday functioning (r = 0.57, 95% CI = [0.24, 0.79]). Test–retest reliability was good (intraclass correlation coefficient = 0.87, 95% CI = [0.77, 0.93]). Most participants rated their experience with ASSET neutrally or positively. DISCUSSION: ASSET is a promising smartphone-based digital assessment of everyday functioning. Future studies may investigate its utility for early diagnosis and evaluation of treatment of Alzheimer's disease.

AB - INTRODUCTION: To investigate the utility of a new digital tool for measuring everyday functioning in preclinical Alzheimer's disease, we piloted the Assessment of Smartphone Everyday Tasks (ASSET) application. METHODS: Forty-six participants (50.3 ± 27.1 years; 67% female; 20 young unimpaired, 17 old unimpaired, 9 mildly cognitively impaired) completed ASSET 7 times. ASSET comprises two main tasks, simulating a Patient Portal and a Calendar. We assessed ASSET's internal consistency, test–retest reliability, and user experience. RESULTS: ASSET main tasks correlated with each other (r = 0.75, 95% confidence interval [CI] = [0.58, 0.86]). Performance on ASSET's Patient Portal related to cognition (r = 0.64, 95% CI = [0.42, 0.79]) and observer ratings of everyday functioning (r = 0.57, 95% CI = [0.24, 0.79]). Test–retest reliability was good (intraclass correlation coefficient = 0.87, 95% CI = [0.77, 0.93]). Most participants rated their experience with ASSET neutrally or positively. DISCUSSION: ASSET is a promising smartphone-based digital assessment of everyday functioning. Future studies may investigate its utility for early diagnosis and evaluation of treatment of Alzheimer's disease.

UR - https://www.scopus.com/pages/publications/85180254427

U2 - 10.1002/dad2.12506

DO - 10.1002/dad2.12506

M3 - Article

SN - 2352-8729

VL - 15

SP - 1

EP - 10

JO - Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring

JF - Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring

IS - 4

M1 - e12506

ER -

Dubbelman MA, Hall TC, Levesque IM, Mimmack KJ, Sikkes SAM, Fischer SH et al. Using a digital tool to detect early changes in everyday functioning in older adults: A pilot study of the Assessment of Smartphone Everyday Tasks (ASSET). Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring. 2023 Dec;15(4):1-10. e12506. Epub 2023 Dec 17. doi: 10.1002/dad2.12506

Using a digital tool to detect early changes in everyday functioning in older adults: A pilot study of the Assessment of Smartphone Everyday Tasks (ASSET)

Abstract

Funding

Access to Document

Persistent URL (handle)

Other files and links

Fingerprint

Cite this