Utility scores for different health states related to depression: individual participant data analysis

S. Kolovos; Judith E Bosmans; Johanna M van Dongen; Birre van Esveld; Dorcas Magai; Annemieke van Straten; Christina van der Feltz-Cornelis; Kirsten M van Steenbergen-Weijenburg; Klaas M Huijbregts; Harm W J van Marwijk; Heleen Riper; Maurits W van Tulder

doi:10.1007/s11136-017-1536-2

Utility scores for different health states related to depression: individual participant data analysis

S. Kolovos, Judith E Bosmans, Johanna M van Dongen, Birre van Esveld, Dorcas Magai, Annemieke van Straten, Christina van der Feltz-Cornelis, Kirsten M van Steenbergen-Weijenburg, Klaas M Huijbregts, Harm W J van Marwijk, Heleen Riper, Maurits W van Tulder

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

OBJECTIVES: Depression is associated with considerable impairments in health-related quality-of-life. However, the relationship between different health states related to depression severity and utility scores is unclear. The aim of this study was to evaluate whether utility scores are different for various health states related to depression severity.

METHODS: We gathered individual participant data from ten randomized controlled trials evaluating depression treatments. The UK EQ-5D and SF-6D tariffs were used to generate utility scores. We defined five health states that were proposed from American Psychiatric Association and National Institute for Clinical Excellence guidelines: remission, minor depression, mild depression, moderate depression, and severe depression. We performed multilevel linear regression analysis.

RESULTS: We included 1629 participants in the analyses. The average EQ-5D utility scores for the five health states were 0.70 (95% CI 0.67-0.73) for remission, 0.62 (95% CI 0.58-0.65) for minor depression, 0.57 (95% CI 0.54-0.61) for mild depression, 0.52 (95%CI 0.49-0.56) for moderate depression, and 0.39 (95% CI 0.35-0.43) for severe depression. In comparison with the EQ-5D, the utility scores based on the SF-6D were similar for remission (EQ-5D = 0.70 vs. SF-6D = 0.69), but higher for severe depression (EQ-5D = 0.39 vs. SF-6D = 0.55).

CONCLUSIONS: We observed statistically significant differences in utility scores between depression health states. Individuals with less severe depressive symptoms had on average statistically significant higher utility scores than individuals suffering from more severe depressive symptomatology. In the present study, EQ-5D had a larger range of values as compared to SF-6D.

Original language	English
Pages (from-to)	1649-1658
Number of pages	10
Journal	Quality of Life Research
Volume	26
Issue number	7
DOIs	https://doi.org/10.1007/s11136-017-1536-2
Publication status	Published - 1 Jul 2017

Funding

The current study has been conducted within the E-COMPARED framework. The E-COMPARED project is funded under the Seventh Framework Program. The content of this article reflects only the authors’ views and the European Community is not liable for any use that may be made of the information contained therein.

Funders	Funder number
Seventh Framework Programme

Keywords

Journal Article
Review

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1007/s11136-017-1536-2

Persistent URL (handle)

Persistent link

Cite this

Kolovos, S., Bosmans, J. E., van Dongen, J. M., van Esveld, B., Magai, D., van Straten, A., van der Feltz-Cornelis, C., van Steenbergen-Weijenburg, K. M., Huijbregts, K. M., van Marwijk, H. W. J., Riper, H., & van Tulder, M. W. (2017). Utility scores for different health states related to depression: individual participant data analysis. Quality of Life Research, 26(7), 1649-1658. https://doi.org/10.1007/s11136-017-1536-2

@article{04f7ae06ef8b47b3964ffc0782ec3173,

title = "Utility scores for different health states related to depression: individual participant data analysis",

abstract = "OBJECTIVES: Depression is associated with considerable impairments in health-related quality-of-life. However, the relationship between different health states related to depression severity and utility scores is unclear. The aim of this study was to evaluate whether utility scores are different for various health states related to depression severity.METHODS: We gathered individual participant data from ten randomized controlled trials evaluating depression treatments. The UK EQ-5D and SF-6D tariffs were used to generate utility scores. We defined five health states that were proposed from American Psychiatric Association and National Institute for Clinical Excellence guidelines: remission, minor depression, mild depression, moderate depression, and severe depression. We performed multilevel linear regression analysis.RESULTS: We included 1629 participants in the analyses. The average EQ-5D utility scores for the five health states were 0.70 (95% CI 0.67-0.73) for remission, 0.62 (95% CI 0.58-0.65) for minor depression, 0.57 (95% CI 0.54-0.61) for mild depression, 0.52 (95%CI 0.49-0.56) for moderate depression, and 0.39 (95% CI 0.35-0.43) for severe depression. In comparison with the EQ-5D, the utility scores based on the SF-6D were similar for remission (EQ-5D = 0.70 vs. SF-6D = 0.69), but higher for severe depression (EQ-5D = 0.39 vs. SF-6D = 0.55).CONCLUSIONS: We observed statistically significant differences in utility scores between depression health states. Individuals with less severe depressive symptoms had on average statistically significant higher utility scores than individuals suffering from more severe depressive symptomatology. In the present study, EQ-5D had a larger range of values as compared to SF-6D.",

keywords = "Journal Article, Review",

author = "S. Kolovos and Bosmans, {Judith E} and {van Dongen}, {Johanna M} and {van Esveld}, Birre and Dorcas Magai and {van Straten}, Annemieke and {van der Feltz-Cornelis}, Christina and {van Steenbergen-Weijenburg}, {Kirsten M} and Huijbregts, {Klaas M} and {van Marwijk}, {Harm W J} and Heleen Riper and {van Tulder}, {Maurits W}",

year = "2017",

month = jul,

day = "1",

doi = "10.1007/s11136-017-1536-2",

language = "English",

volume = "26",

pages = "1649--1658",

journal = "Quality of Life Research",

issn = "0962-9343",

publisher = "Springer Netherlands",

number = "7",

}

Kolovos, S, Bosmans, JE , van Dongen, JM, van Esveld, B, Magai, D, van Straten, A, van der Feltz-Cornelis, C, van Steenbergen-Weijenburg, KM, Huijbregts, KM, van Marwijk, HWJ, Riper, H & van Tulder, MW 2017, 'Utility scores for different health states related to depression: individual participant data analysis', Quality of Life Research, vol. 26, no. 7, pp. 1649-1658. https://doi.org/10.1007/s11136-017-1536-2

TY - JOUR

T1 - Utility scores for different health states related to depression

T2 - individual participant data analysis

AU - Kolovos, S.

AU - Bosmans, Judith E

AU - van Dongen, Johanna M

AU - van Esveld, Birre

AU - Magai, Dorcas

AU - van Straten, Annemieke

AU - van der Feltz-Cornelis, Christina

AU - van Steenbergen-Weijenburg, Kirsten M

AU - Huijbregts, Klaas M

AU - van Marwijk, Harm W J

AU - Riper, Heleen

AU - van Tulder, Maurits W

PY - 2017/7/1

Y1 - 2017/7/1

N2 - OBJECTIVES: Depression is associated with considerable impairments in health-related quality-of-life. However, the relationship between different health states related to depression severity and utility scores is unclear. The aim of this study was to evaluate whether utility scores are different for various health states related to depression severity.METHODS: We gathered individual participant data from ten randomized controlled trials evaluating depression treatments. The UK EQ-5D and SF-6D tariffs were used to generate utility scores. We defined five health states that were proposed from American Psychiatric Association and National Institute for Clinical Excellence guidelines: remission, minor depression, mild depression, moderate depression, and severe depression. We performed multilevel linear regression analysis.RESULTS: We included 1629 participants in the analyses. The average EQ-5D utility scores for the five health states were 0.70 (95% CI 0.67-0.73) for remission, 0.62 (95% CI 0.58-0.65) for minor depression, 0.57 (95% CI 0.54-0.61) for mild depression, 0.52 (95%CI 0.49-0.56) for moderate depression, and 0.39 (95% CI 0.35-0.43) for severe depression. In comparison with the EQ-5D, the utility scores based on the SF-6D were similar for remission (EQ-5D = 0.70 vs. SF-6D = 0.69), but higher for severe depression (EQ-5D = 0.39 vs. SF-6D = 0.55).CONCLUSIONS: We observed statistically significant differences in utility scores between depression health states. Individuals with less severe depressive symptoms had on average statistically significant higher utility scores than individuals suffering from more severe depressive symptomatology. In the present study, EQ-5D had a larger range of values as compared to SF-6D.

AB - OBJECTIVES: Depression is associated with considerable impairments in health-related quality-of-life. However, the relationship between different health states related to depression severity and utility scores is unclear. The aim of this study was to evaluate whether utility scores are different for various health states related to depression severity.METHODS: We gathered individual participant data from ten randomized controlled trials evaluating depression treatments. The UK EQ-5D and SF-6D tariffs were used to generate utility scores. We defined five health states that were proposed from American Psychiatric Association and National Institute for Clinical Excellence guidelines: remission, minor depression, mild depression, moderate depression, and severe depression. We performed multilevel linear regression analysis.RESULTS: We included 1629 participants in the analyses. The average EQ-5D utility scores for the five health states were 0.70 (95% CI 0.67-0.73) for remission, 0.62 (95% CI 0.58-0.65) for minor depression, 0.57 (95% CI 0.54-0.61) for mild depression, 0.52 (95%CI 0.49-0.56) for moderate depression, and 0.39 (95% CI 0.35-0.43) for severe depression. In comparison with the EQ-5D, the utility scores based on the SF-6D were similar for remission (EQ-5D = 0.70 vs. SF-6D = 0.69), but higher for severe depression (EQ-5D = 0.39 vs. SF-6D = 0.55).CONCLUSIONS: We observed statistically significant differences in utility scores between depression health states. Individuals with less severe depressive symptoms had on average statistically significant higher utility scores than individuals suffering from more severe depressive symptomatology. In the present study, EQ-5D had a larger range of values as compared to SF-6D.

KW - Journal Article

KW - Review

UR - http://www.scopus.com/inward/record.url?scp=85014323199&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85014323199&partnerID=8YFLogxK

U2 - 10.1007/s11136-017-1536-2

DO - 10.1007/s11136-017-1536-2

M3 - Article

C2 - 28260149

SN - 0962-9343

VL - 26

SP - 1649

EP - 1658

JO - Quality of Life Research

JF - Quality of Life Research

IS - 7

ER -

Utility scores for different health states related to depression: individual participant data analysis

Abstract

Funding

Keywords

UN SDGs

Access to Document

Persistent URL (handle)

Other files and links

Fingerprint

Cite this