TY - JOUR
T1 - Validation of a capillary electrophoresis method for the enantiomeric purity testing of ropivacaine, a new local anaesthetic compound
AU - Sänger-Van De Griend, C. E.
AU - Gröningsson, K.
PY - 1996/1
Y1 - 1996/1
N2 - A capillary electrophoresis method for the determination of the enantiomeric purity of ropivacaine, a new local anaesthetic compound developed by Astra Pain Control AB, has been validated. The method showed the required limit of quantitation of 0.1%, enantiomeric impurity and proved to be robust. Good performances were also shown for specificity, linearity, system repeatability and accuracy. The same capillary electrophoresis method can also be used to simultaneously chirally resolve homologues and impurities of ropivacaine.
AB - A capillary electrophoresis method for the determination of the enantiomeric purity of ropivacaine, a new local anaesthetic compound developed by Astra Pain Control AB, has been validated. The method showed the required limit of quantitation of 0.1%, enantiomeric impurity and proved to be robust. Good performances were also shown for specificity, linearity, system repeatability and accuracy. The same capillary electrophoresis method can also be used to simultaneously chirally resolve homologues and impurities of ropivacaine.
KW - Capillary electrophoresis
KW - Enantiomer separation
KW - Local anaesthetics
KW - Pharmaceutical analysis
KW - Ropivacaine
KW - Validation
UR - http://www.scopus.com/inward/record.url?scp=0342398234&partnerID=8YFLogxK
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U2 - 10.1016/0731-7085(95)01642-2
DO - 10.1016/0731-7085(95)01642-2
M3 - Article
C2 - 8851754
AN - SCOPUS:0342398234
VL - 14
SP - 295
EP - 304
JO - Journal of Pharmaceutical and Biomedical Analysis
JF - Journal of Pharmaceutical and Biomedical Analysis
SN - 0731-7085
IS - 3
ER -