Validation of a capillary electrophoresis method for the enantiomeric purity testing of ropivacaine, a new local anaesthetic compound

C. E. Sänger-Van De Griend, K. Gröningsson*

*Corresponding author for this work

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

A capillary electrophoresis method for the determination of the enantiomeric purity of ropivacaine, a new local anaesthetic compound developed by Astra Pain Control AB, has been validated. The method showed the required limit of quantitation of 0.1%, enantiomeric impurity and proved to be robust. Good performances were also shown for specificity, linearity, system repeatability and accuracy. The same capillary electrophoresis method can also be used to simultaneously chirally resolve homologues and impurities of ropivacaine.

Original languageEnglish
Pages (from-to)295-304
Number of pages10
JournalJournal of Pharmaceutical and Biomedical Analysis
Volume14
Issue number3
DOIs
Publication statusPublished - Jan 1996

Keywords

  • Capillary electrophoresis
  • Enantiomer separation
  • Local anaesthetics
  • Pharmaceutical analysis
  • Ropivacaine
  • Validation

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