Validation of a capillary electrophoresis method for the enantiomeric purity testing of ropivacaine, a new local anaesthetic compound

C. E. Sänger-Van De Griend; K. Gröningsson

doi:10.1016/0731-7085(95)01642-2

Validation of a capillary electrophoresis method for the enantiomeric purity testing of ropivacaine, a new local anaesthetic compound

C. E. Sänger-Van De Griend
, K. Gröningsson^*

^*Corresponding author for this work

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

A capillary electrophoresis method for the determination of the enantiomeric purity of ropivacaine, a new local anaesthetic compound developed by Astra Pain Control AB, has been validated. The method showed the required limit of quantitation of 0.1%, enantiomeric impurity and proved to be robust. Good performances were also shown for specificity, linearity, system repeatability and accuracy. The same capillary electrophoresis method can also be used to simultaneously chirally resolve homologues and impurities of ropivacaine.

Original language	English
Pages (from-to)	295-304
Number of pages	10
Journal	Journal of Pharmaceutical and Biomedical Analysis
Volume	14
Issue number	3
DOIs	https://doi.org/10.1016/0731-7085(95)01642-2
Publication status	Published - Jan 1996

Keywords

Capillary electrophoresis
Enantiomer separation
Local anaesthetics
Pharmaceutical analysis
Ropivacaine
Validation

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10.1016/0731-7085(95)01642-2

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title = "Validation of a capillary electrophoresis method for the enantiomeric purity testing of ropivacaine, a new local anaesthetic compound",

abstract = "A capillary electrophoresis method for the determination of the enantiomeric purity of ropivacaine, a new local anaesthetic compound developed by Astra Pain Control AB, has been validated. The method showed the required limit of quantitation of 0.1\%, enantiomeric impurity and proved to be robust. Good performances were also shown for specificity, linearity, system repeatability and accuracy. The same capillary electrophoresis method can also be used to simultaneously chirally resolve homologues and impurities of ropivacaine.",

keywords = "Capillary electrophoresis, Enantiomer separation, Local anaesthetics, Pharmaceutical analysis, Ropivacaine, Validation",

author = "\{S{\"a}nger-Van De Griend\}, \{C. E.\} and K. Gr{\"o}ningsson",

year = "1996",

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N2 - A capillary electrophoresis method for the determination of the enantiomeric purity of ropivacaine, a new local anaesthetic compound developed by Astra Pain Control AB, has been validated. The method showed the required limit of quantitation of 0.1%, enantiomeric impurity and proved to be robust. Good performances were also shown for specificity, linearity, system repeatability and accuracy. The same capillary electrophoresis method can also be used to simultaneously chirally resolve homologues and impurities of ropivacaine.

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KW - Capillary electrophoresis

KW - Enantiomer separation

KW - Local anaesthetics

KW - Pharmaceutical analysis

KW - Ropivacaine

KW - Validation

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JF - Journal of Pharmaceutical and Biomedical Analysis

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ER -

Validation of a capillary electrophoresis method for the enantiomeric purity testing of ropivacaine, a new local anaesthetic compound

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Keywords

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