VAR2CSA serology to detect plasmodium falciparum transmission patterns in pregnancy

Ana Maria Fonseca; Raquel González; Azucena Bardají; Chenjerai Jairoce; Maria Rupérez; Alfons Jiménez; Llorenç Quintó; Pau Cisteró; Anifa Vala; Charfudin Sacoor; Himanshu Gupta; Jennifer Hegewisch-Taylor; Joe Brew; Nicaise Tuikue Ndam; Simon Kariuki; Marta López; Carlota Dobaño; Chetan E. Chitnis; Peter Ouma; Michael Ramharter; Salim Abdulla; John J. Aponte; Achille Massougbodji; Valerie Briand; Ghyslain Mombo-Ngoma; Meghna Desai; Michel Cot; Arsenio Nhacolo; Esperança Sevene; Eusebio Macete; Clara Menéndez; Alfredo Mayor

doi:10.3201/eid2510.181177

VAR2CSA serology to detect plasmodium falciparum transmission patterns in pregnancy

Ana Maria Fonseca, Raquel González, Azucena Bardají, Chenjerai Jairoce, Maria Rupérez, Alfons Jiménez, Llorenç Quintó, Pau Cisteró, Anifa Vala, Charfudin Sacoor, Himanshu Gupta, Jennifer Hegewisch-Taylor, Joe Brew, Nicaise Tuikue Ndam, Simon Kariuki, Marta López, Carlota Dobaño, Chetan E. Chitnis, Peter Ouma, Michael RamharterSalim Abdulla, John J. Aponte, Achille Massougbodji, Valerie Briand, Ghyslain Mombo-Ngoma, Meghna Desai, Michel Cot, Arsenio Nhacolo, Esperança Sevene, Eusebio Macete, Clara Menéndez, Alfredo Mayor^*

^*Corresponding author for this work

Athena Institute

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

Pregnant women constitute a promising sentinel group for continuous monitoring of malaria transmission. To identify antibody signatures of recent Plasmodium falciparum exposure during pregnancy, we dissected IgG responses against VAR2CSA, the parasite antigen that mediates placental sequestration. We used a multiplex peptide-based suspension array in 2,354 samples from pregnant women from Mozambique, Benin, Kenya, Gabon, Tanzania, and Spain. Two VAR2CSA peptides of limited polymorphism were immunogenic and targeted by IgG responses readily boosted during infection and with estimated half-lives of <2 years. Seroprevalence against these peptides reflected declines and rebounds of transmission in southern Mozambique during 2004-2012, reduced exposure associated with use of preventive measures during pregnancy, and local clusters of transmission that were missed by detection of P. falciparum infections. These data suggest that VAR2CSA serology can provide a useful adjunct for the fine-scale estimation of the malaria burden among pregnant women over time and space.

Original language	English
Pages (from-to)	1851-1860
Number of pages	10
Journal	Emerging Infectious Diseases
Volume	25
Issue number	10
Early online date	30 Aug 2019
DOIs	https://doi.org/10.3201/eid2510.181177
Publication status	Published - Oct 2019

Funding

This study was supported by the Malaria Eradication Scientific Alliance; the European and Developing Countries Clinical Trials Partnership; the Malaria in Pregnancy Consortium; and grants from Banco de Bilbao, Vizcaya, Argentaria Foundation (BBVA 02-0), Instituto de Salud Carlos III (PS09/01113, PI13/01478, and CES10/021-I3SNS, to A. Mayor), and Ministerio de Ciencia e Innovacion (RYC-2008-02631, to C.D.), the Fundação para a Ciência e Tecnologia (SFRH/BD/51696/2011, to A.M.F.), the Department of Science & Technology, Government of India (SB/OS/PDF-043/2015-16, to H.G.) and the Department d’Universitats I Recerca de la Generalitat de Catalunya (AGAUR; 2017SGR664, to A.M.). The Centro de Investigacao em Saude da Manhica receives core support from the Spanish Agency for International Cooperation and Development. The Malaria in Pregnancy Consortium is funded by a grant from the Bill & Melinda Gates Foundation to the Liverpool School of Tropical Medicine and the Malaria

Funders	Funder number
A.M.F.
Banco de Bilbao, Vizcaya, Argentaria Foundation	BBVA 02-0
Barcelona Institute of
Ci?ncia e Tecnologia
Department of Science & Technology, Government of India
Fundação para a Ciência e Tecnologia	SFRH/BD/51696/2011
Malaria Eradication Scientific
Malaria Eradication Scientific Alliance
Malaria in Pregnancy Consortium
Ministerio de Ciencia e Innovacion	RYC-2008-02631
Spanish Agency for International Cooperation and Development
Bill and Melinda Gates Foundation
Center for Global Health
Center for Outcomes Research and Evaluation, Yale School of Medicine
Liverpool School of Tropical Medicine
European and Developing Countries Clinical Trials Partnership
Generalitat de Catalunya	62523828, p8
Agència de Gestió d'Ajuts Universitaris i de Recerca	2017SGR664
Japan International Cooperation Agency
Instituto de Salud Carlos III	PS09/01113, CES10/021-I3SNS, PI13/01478
Ministerio de Ciencia e Innovación
Department of Science and Technology, Government of Kerala	SB/OS/PDF-043/2015-16
Departament d'Universitats, Recerca i Societat de la Informació

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3201/eid2510.181177

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Fonseca, A. M., González, R., Bardají, A., Jairoce, C., Rupérez, M., Jiménez, A., Quintó, L., Cisteró, P., Vala, A., Sacoor, C., Gupta, H., Hegewisch-Taylor, J., Brew, J., Ndam, N. T., Kariuki, S., López, M., Dobaño, C., Chitnis, C. E., Ouma, P., ... Mayor, A. (2019). VAR2CSA serology to detect plasmodium falciparum transmission patterns in pregnancy. Emerging Infectious Diseases, 25(10), 1851-1860. https://doi.org/10.3201/eid2510.181177

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abstract = "Pregnant women constitute a promising sentinel group for continuous monitoring of malaria transmission. To identify antibody signatures of recent Plasmodium falciparum exposure during pregnancy, we dissected IgG responses against VAR2CSA, the parasite antigen that mediates placental sequestration. We used a multiplex peptide-based suspension array in 2,354 samples from pregnant women from Mozambique, Benin, Kenya, Gabon, Tanzania, and Spain. Two VAR2CSA peptides of limited polymorphism were immunogenic and targeted by IgG responses readily boosted during infection and with estimated half-lives of <2 years. Seroprevalence against these peptides reflected declines and rebounds of transmission in southern Mozambique during 2004-2012, reduced exposure associated with use of preventive measures during pregnancy, and local clusters of transmission that were missed by detection of P. falciparum infections. These data suggest that VAR2CSA serology can provide a useful adjunct for the fine-scale estimation of the malaria burden among pregnant women over time and space.",

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Fonseca, AM, González, R, Bardají, A, Jairoce, C, Rupérez, M, Jiménez, A, Quintó, L, Cisteró, P, Vala, A, Sacoor, C, Gupta, H, Hegewisch-Taylor, J, Brew, J, Ndam, NT, Kariuki, S, López, M, Dobaño, C, Chitnis, CE, Ouma, P, Ramharter, M, Abdulla, S, Aponte, JJ, Massougbodji, A, Briand, V, Mombo-Ngoma, G, Desai, M, Cot, M, Nhacolo, A, Sevene, E, Macete, E, Menéndez, C & Mayor, A 2019, 'VAR2CSA serology to detect plasmodium falciparum transmission patterns in pregnancy', Emerging Infectious Diseases, vol. 25, no. 10, pp. 1851-1860. https://doi.org/10.3201/eid2510.181177

TY - JOUR

T1 - VAR2CSA serology to detect plasmodium falciparum transmission patterns in pregnancy

AU - Fonseca, Ana Maria

AU - González, Raquel

AU - Bardají, Azucena

AU - Jairoce, Chenjerai

AU - Rupérez, Maria

AU - Jiménez, Alfons

AU - Quintó, Llorenç

AU - Cisteró, Pau

AU - Vala, Anifa

AU - Sacoor, Charfudin

AU - Gupta, Himanshu

AU - Hegewisch-Taylor, Jennifer

AU - Brew, Joe

AU - Ndam, Nicaise Tuikue

AU - Kariuki, Simon

AU - López, Marta

AU - Dobaño, Carlota

AU - Chitnis, Chetan E.

AU - Ouma, Peter

AU - Ramharter, Michael

AU - Abdulla, Salim

AU - Aponte, John J.

AU - Massougbodji, Achille

AU - Briand, Valerie

AU - Mombo-Ngoma, Ghyslain

AU - Desai, Meghna

AU - Cot, Michel

AU - Nhacolo, Arsenio

AU - Sevene, Esperança

AU - Macete, Eusebio

AU - Menéndez, Clara

AU - Mayor, Alfredo

PY - 2019/10

Y1 - 2019/10

N2 - Pregnant women constitute a promising sentinel group for continuous monitoring of malaria transmission. To identify antibody signatures of recent Plasmodium falciparum exposure during pregnancy, we dissected IgG responses against VAR2CSA, the parasite antigen that mediates placental sequestration. We used a multiplex peptide-based suspension array in 2,354 samples from pregnant women from Mozambique, Benin, Kenya, Gabon, Tanzania, and Spain. Two VAR2CSA peptides of limited polymorphism were immunogenic and targeted by IgG responses readily boosted during infection and with estimated half-lives of <2 years. Seroprevalence against these peptides reflected declines and rebounds of transmission in southern Mozambique during 2004-2012, reduced exposure associated with use of preventive measures during pregnancy, and local clusters of transmission that were missed by detection of P. falciparum infections. These data suggest that VAR2CSA serology can provide a useful adjunct for the fine-scale estimation of the malaria burden among pregnant women over time and space.

AB - Pregnant women constitute a promising sentinel group for continuous monitoring of malaria transmission. To identify antibody signatures of recent Plasmodium falciparum exposure during pregnancy, we dissected IgG responses against VAR2CSA, the parasite antigen that mediates placental sequestration. We used a multiplex peptide-based suspension array in 2,354 samples from pregnant women from Mozambique, Benin, Kenya, Gabon, Tanzania, and Spain. Two VAR2CSA peptides of limited polymorphism were immunogenic and targeted by IgG responses readily boosted during infection and with estimated half-lives of <2 years. Seroprevalence against these peptides reflected declines and rebounds of transmission in southern Mozambique during 2004-2012, reduced exposure associated with use of preventive measures during pregnancy, and local clusters of transmission that were missed by detection of P. falciparum infections. These data suggest that VAR2CSA serology can provide a useful adjunct for the fine-scale estimation of the malaria burden among pregnant women over time and space.

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VAR2CSA serology to detect plasmodium falciparum transmission patterns in pregnancy

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