Variants in MTNR1B influence fasting glucose levels

I. Prokopenko, C. Langenberg, J.C. Florez, R. Saxena, N. Soranzo, G. Thorleifsson, R.J.F. Loos, A.K. Manning, A.U. Jackson, Y.S. Aulchenko, S.C. Potter, M.R. Erdos, S. Sanna, J.J. Hottenga, E. Wheeler, M. Kaakinen, V. Lyssenko, W.-M. Chen, K. Ahmadi, J.S. BeckmannR.N. Bergman, M. Bochud, L.L. Bonnycastle, T.A. Buchanan, A. Cao, A. Cervin, L. Coin, F.S. Collins, L. Crisponi, E.J.C. de Geus, A. Dehghan, P. Deloukas, A.S.F. Doney, P. Elliott, N.B. Freimer, V. Gateva, C. Herder, A. Hofman, T.E. Hughes, S. Hunt, T. Illig, M. Inouye, B. Isomaa, T. Johnson, A. Kong, M. Krestyaninova, J. Kuusisto, M. Laaks, N. Lim, U. Lindblad, C.M. Lindgren, O.T. McCann, K.L. Mohlke, A.D. Morris, S. Naitza, M. Orrù, C.N.A. Palmer, A. Pouta, J. Randall, W. Rathmann, J. Saramies, P. Scheet, L.J. Scott, A. Scuteri, S. Sharp, E.J.G. Sijbrands, J.H. Smit, K. Song, V. Steinthorsdottir, H.M. Stringham, T. Tuomi, J. Tuomilehto, A.G. Uitterlinden, B.F. Voight, D. Waterworth, H.-E. Wichmann, G. Willemsen, J.C.M. Witteman, X. Yuan, J.H. Zha, E. Zeggini, D. Schlessinger, M. Sandhu, D.I. Boomsma, M. Uda, T.D. Spector, B.W.J.H. Penninx, D. Altshuler, P. Vollenweider, M.-R. Jarvelin, E. Lakatta, G. Waeber, C.S. Fox, L. Peltonen, L.C. Groop, V. Mooser, L.A. Cupples, U. Thorsteinsdottir, G.R. Abecasis

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Abstract

To identify previously unknown genetic loci associated with fasting glucose concentrations, we examined the leading association signals in ten genome-wide association scans involving a total of 36,610 individuals of European descent. Variants in the gene encoding melatonin receptor 1B (MTNR1B) were consistently associated with fasting glucose across all ten studies. The strongest signal was observed at rs10830963, where each G allele (frequency 0.30 in HapMap CEU) was associated with an increase of 0.07 (95% CI = 0.06-0.08) mmol/l in fasting glucose levels (P = 3.2 × 10
Original languageEnglish
Pages (from-to)77-81
JournalNature Genetics
Volume41
Issue number1
DOIs
Publication statusPublished - 2009

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