Variants in MTNR1B influence fasting glucose levels

I. Prokopenko, C. Langenberg, J.C. Florez, R. Saxena, N. Soranzo, G. Thorleifsson, R.J.F. Loos, A.K. Manning, A.U. Jackson, Y.S. Aulchenko, S.C. Potter, M.R. Erdos, S. Sanna, J.J. Hottenga, E. Wheeler, M. Kaakinen, V. Lyssenko, W.-M. Chen, K. Ahmadi, J.S. Beckmann & 79 others R.N. Bergman, M. Bochud, L.L. Bonnycastle, T.A. Buchanan, A. Cao, A. Cervin, L. Coin, F.S. Collins, L. Crisponi, E.J.C. de Geus, A. Dehghan, P. Deloukas, A.S.F. Doney, P. Elliott, N.B. Freimer, V. Gateva, C. Herder, A. Hofman, T.E. Hughes, S. Hunt, T. Illig, M. Inouye, B. Isomaa, T. Johnson, A. Kong, M. Krestyaninova, J. Kuusisto, M. Laaks, N. Lim, U. Lindblad, C.M. Lindgren, O.T. McCann, K.L. Mohlke, A.D. Morris, S. Naitza, M. Orrù, C.N.A. Palmer, A. Pouta, J. Randall, W. Rathmann, J. Saramies, P. Scheet, L.J. Scott, A. Scuteri, S. Sharp, E.J.G. Sijbrands, J.H. Smit, K. Song, V. Steinthorsdottir, H.M. Stringham, T. Tuomi, J. Tuomilehto, A.G. Uitterlinden, B.F. Voight, D. Waterworth, H.-E. Wichmann, G. Willemsen, J.C.M. Witteman, X. Yuan, J.H. Zha, E. Zeggini, D. Schlessinger, M. Sandhu, D.I. Boomsma, M. Uda, T.D. Spector, B.W.J.H. Penninx, D. Altshuler, P. Vollenweider, M.-R. Jarvelin, E. Lakatta, G. Waeber, C.S. Fox, L. Peltonen, L.C. Groop, V. Mooser, L.A. Cupples, U. Thorsteinsdottir, G.R. Abecasis

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

To identify previously unknown genetic loci associated with fasting glucose concentrations, we examined the leading association signals in ten genome-wide association scans involving a total of 36,610 individuals of European descent. Variants in the gene encoding melatonin receptor 1B (MTNR1B) were consistently associated with fasting glucose across all ten studies. The strongest signal was observed at rs10830963, where each G allele (frequency 0.30 in HapMap CEU) was associated with an increase of 0.07 (95% CI = 0.06-0.08) mmol/l in fasting glucose levels (P = 3.2 × 10
Original languageEnglish
Pages (from-to)77-81
JournalNature Genetics
Volume41
Issue number1
DOIs
Publication statusPublished - 2009

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Melatonin MT2 Receptor
Fasting
Glucose
HapMap Project
Genetic Loci
Genome-Wide Association Study
Gene Frequency
Genes

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Prokopenko, I., Langenberg, C., Florez, J. C., Saxena, R., Soranzo, N., Thorleifsson, G., ... Abecasis, G. R. (2009). Variants in MTNR1B influence fasting glucose levels. Nature Genetics, 41(1), 77-81. https://doi.org/10.1038/ng.290
Prokopenko, I. ; Langenberg, C. ; Florez, J.C. ; Saxena, R. ; Soranzo, N. ; Thorleifsson, G. ; Loos, R.J.F. ; Manning, A.K. ; Jackson, A.U. ; Aulchenko, Y.S. ; Potter, S.C. ; Erdos, M.R. ; Sanna, S. ; Hottenga, J.J. ; Wheeler, E. ; Kaakinen, M. ; Lyssenko, V. ; Chen, W.-M. ; Ahmadi, K. ; Beckmann, J.S. ; Bergman, R.N. ; Bochud, M. ; Bonnycastle, L.L. ; Buchanan, T.A. ; Cao, A. ; Cervin, A. ; Coin, L. ; Collins, F.S. ; Crisponi, L. ; de Geus, E.J.C. ; Dehghan, A. ; Deloukas, P. ; Doney, A.S.F. ; Elliott, P. ; Freimer, N.B. ; Gateva, V. ; Herder, C. ; Hofman, A. ; Hughes, T.E. ; Hunt, S. ; Illig, T. ; Inouye, M. ; Isomaa, B. ; Johnson, T. ; Kong, A. ; Krestyaninova, M. ; Kuusisto, J. ; Laaks, M. ; Lim, N. ; Lindblad, U. ; Lindgren, C.M. ; McCann, O.T. ; Mohlke, K.L. ; Morris, A.D. ; Naitza, S. ; Orrù, M. ; Palmer, C.N.A. ; Pouta, A. ; Randall, J. ; Rathmann, W. ; Saramies, J. ; Scheet, P. ; Scott, L.J. ; Scuteri, A. ; Sharp, S. ; Sijbrands, E.J.G. ; Smit, J.H. ; Song, K. ; Steinthorsdottir, V. ; Stringham, H.M. ; Tuomi, T. ; Tuomilehto, J. ; Uitterlinden, A.G. ; Voight, B.F. ; Waterworth, D. ; Wichmann, H.-E. ; Willemsen, G. ; Witteman, J.C.M. ; Yuan, X. ; Zha, J.H. ; Zeggini, E. ; Schlessinger, D. ; Sandhu, M. ; Boomsma, D.I. ; Uda, M. ; Spector, T.D. ; Penninx, B.W.J.H. ; Altshuler, D. ; Vollenweider, P. ; Jarvelin, M.-R. ; Lakatta, E. ; Waeber, G. ; Fox, C.S. ; Peltonen, L. ; Groop, L.C. ; Mooser, V. ; Cupples, L.A. ; Thorsteinsdottir, U. ; Abecasis, G.R. / Variants in MTNR1B influence fasting glucose levels. In: Nature Genetics. 2009 ; Vol. 41, No. 1. pp. 77-81.
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abstract = "To identify previously unknown genetic loci associated with fasting glucose concentrations, we examined the leading association signals in ten genome-wide association scans involving a total of 36,610 individuals of European descent. Variants in the gene encoding melatonin receptor 1B (MTNR1B) were consistently associated with fasting glucose across all ten studies. The strongest signal was observed at rs10830963, where each G allele (frequency 0.30 in HapMap CEU) was associated with an increase of 0.07 (95{\%} CI = 0.06-0.08) mmol/l in fasting glucose levels (P = 3.2 × 10",
author = "I. Prokopenko and C. Langenberg and J.C. Florez and R. Saxena and N. Soranzo and G. Thorleifsson and R.J.F. Loos and A.K. Manning and A.U. Jackson and Y.S. Aulchenko and S.C. Potter and M.R. Erdos and S. Sanna and J.J. Hottenga and E. Wheeler and M. Kaakinen and V. Lyssenko and W.-M. Chen and K. Ahmadi and J.S. Beckmann and R.N. Bergman and M. Bochud and L.L. Bonnycastle and T.A. Buchanan and A. Cao and A. Cervin and L. Coin and F.S. Collins and L. Crisponi and {de Geus}, E.J.C. and A. Dehghan and P. Deloukas and A.S.F. Doney and P. Elliott and N.B. Freimer and V. Gateva and C. Herder and A. Hofman and T.E. Hughes and S. Hunt and T. Illig and M. Inouye and B. Isomaa and T. Johnson and A. Kong and M. Krestyaninova and J. Kuusisto and M. Laaks and N. Lim and U. Lindblad and C.M. Lindgren and O.T. McCann and K.L. Mohlke and A.D. Morris and S. Naitza and M. Orr{\`u} and C.N.A. Palmer and A. Pouta and J. Randall and W. Rathmann and J. Saramies and P. Scheet and L.J. Scott and A. Scuteri and S. Sharp and E.J.G. Sijbrands and J.H. Smit and K. Song and V. Steinthorsdottir and H.M. Stringham and T. Tuomi and J. Tuomilehto and A.G. Uitterlinden and B.F. Voight and D. Waterworth and H.-E. Wichmann and G. Willemsen and J.C.M. Witteman and X. Yuan and J.H. Zha and E. Zeggini and D. Schlessinger and M. Sandhu and D.I. Boomsma and M. Uda and T.D. Spector and B.W.J.H. Penninx and D. Altshuler and P. Vollenweider and M.-R. Jarvelin and E. Lakatta and G. Waeber and C.S. Fox and L. Peltonen and L.C. Groop and V. Mooser and L.A. Cupples and U. Thorsteinsdottir and G.R. Abecasis",
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Prokopenko, I, Langenberg, C, Florez, JC, Saxena, R, Soranzo, N, Thorleifsson, G, Loos, RJF, Manning, AK, Jackson, AU, Aulchenko, YS, Potter, SC, Erdos, MR, Sanna, S, Hottenga, JJ, Wheeler, E, Kaakinen, M, Lyssenko, V, Chen, W-M, Ahmadi, K, Beckmann, JS, Bergman, RN, Bochud, M, Bonnycastle, LL, Buchanan, TA, Cao, A, Cervin, A, Coin, L, Collins, FS, Crisponi, L, de Geus, EJC, Dehghan, A, Deloukas, P, Doney, ASF, Elliott, P, Freimer, NB, Gateva, V, Herder, C, Hofman, A, Hughes, TE, Hunt, S, Illig, T, Inouye, M, Isomaa, B, Johnson, T, Kong, A, Krestyaninova, M, Kuusisto, J, Laaks, M, Lim, N, Lindblad, U, Lindgren, CM, McCann, OT, Mohlke, KL, Morris, AD, Naitza, S, Orrù, M, Palmer, CNA, Pouta, A, Randall, J, Rathmann, W, Saramies, J, Scheet, P, Scott, LJ, Scuteri, A, Sharp, S, Sijbrands, EJG, Smit, JH, Song, K, Steinthorsdottir, V, Stringham, HM, Tuomi, T, Tuomilehto, J, Uitterlinden, AG, Voight, BF, Waterworth, D, Wichmann, H-E, Willemsen, G, Witteman, JCM, Yuan, X, Zha, JH, Zeggini, E, Schlessinger, D, Sandhu, M, Boomsma, DI, Uda, M, Spector, TD, Penninx, BWJH, Altshuler, D, Vollenweider, P, Jarvelin, M-R, Lakatta, E, Waeber, G, Fox, CS, Peltonen, L, Groop, LC, Mooser, V, Cupples, LA, Thorsteinsdottir, U & Abecasis, GR 2009, 'Variants in MTNR1B influence fasting glucose levels' Nature Genetics, vol. 41, no. 1, pp. 77-81. https://doi.org/10.1038/ng.290

Variants in MTNR1B influence fasting glucose levels. / Prokopenko, I.; Langenberg, C.; Florez, J.C.; Saxena, R.; Soranzo, N.; Thorleifsson, G.; Loos, R.J.F.; Manning, A.K.; Jackson, A.U.; Aulchenko, Y.S.; Potter, S.C.; Erdos, M.R.; Sanna, S.; Hottenga, J.J.; Wheeler, E.; Kaakinen, M.; Lyssenko, V.; Chen, W.-M.; Ahmadi, K.; Beckmann, J.S.; Bergman, R.N.; Bochud, M.; Bonnycastle, L.L.; Buchanan, T.A.; Cao, A.; Cervin, A.; Coin, L.; Collins, F.S.; Crisponi, L.; de Geus, E.J.C.; Dehghan, A.; Deloukas, P.; Doney, A.S.F.; Elliott, P.; Freimer, N.B.; Gateva, V.; Herder, C.; Hofman, A.; Hughes, T.E.; Hunt, S.; Illig, T.; Inouye, M.; Isomaa, B.; Johnson, T.; Kong, A.; Krestyaninova, M.; Kuusisto, J.; Laaks, M.; Lim, N.; Lindblad, U.; Lindgren, C.M.; McCann, O.T.; Mohlke, K.L.; Morris, A.D.; Naitza, S.; Orrù, M.; Palmer, C.N.A.; Pouta, A.; Randall, J.; Rathmann, W.; Saramies, J.; Scheet, P.; Scott, L.J.; Scuteri, A.; Sharp, S.; Sijbrands, E.J.G.; Smit, J.H.; Song, K.; Steinthorsdottir, V.; Stringham, H.M.; Tuomi, T.; Tuomilehto, J.; Uitterlinden, A.G.; Voight, B.F.; Waterworth, D.; Wichmann, H.-E.; Willemsen, G.; Witteman, J.C.M.; Yuan, X.; Zha, J.H.; Zeggini, E.; Schlessinger, D.; Sandhu, M.; Boomsma, D.I.; Uda, M.; Spector, T.D.; Penninx, B.W.J.H.; Altshuler, D.; Vollenweider, P.; Jarvelin, M.-R.; Lakatta, E.; Waeber, G.; Fox, C.S.; Peltonen, L.; Groop, L.C.; Mooser, V.; Cupples, L.A.; Thorsteinsdottir, U.; Abecasis, G.R.

In: Nature Genetics, Vol. 41, No. 1, 2009, p. 77-81.

Research output: Contribution to JournalArticleAcademicpeer-review

TY - JOUR

T1 - Variants in MTNR1B influence fasting glucose levels

AU - Prokopenko, I.

AU - Langenberg, C.

AU - Florez, J.C.

AU - Saxena, R.

AU - Soranzo, N.

AU - Thorleifsson, G.

AU - Loos, R.J.F.

AU - Manning, A.K.

AU - Jackson, A.U.

AU - Aulchenko, Y.S.

AU - Potter, S.C.

AU - Erdos, M.R.

AU - Sanna, S.

AU - Hottenga, J.J.

AU - Wheeler, E.

AU - Kaakinen, M.

AU - Lyssenko, V.

AU - Chen, W.-M.

AU - Ahmadi, K.

AU - Beckmann, J.S.

AU - Bergman, R.N.

AU - Bochud, M.

AU - Bonnycastle, L.L.

AU - Buchanan, T.A.

AU - Cao, A.

AU - Cervin, A.

AU - Coin, L.

AU - Collins, F.S.

AU - Crisponi, L.

AU - de Geus, E.J.C.

AU - Dehghan, A.

AU - Deloukas, P.

AU - Doney, A.S.F.

AU - Elliott, P.

AU - Freimer, N.B.

AU - Gateva, V.

AU - Herder, C.

AU - Hofman, A.

AU - Hughes, T.E.

AU - Hunt, S.

AU - Illig, T.

AU - Inouye, M.

AU - Isomaa, B.

AU - Johnson, T.

AU - Kong, A.

AU - Krestyaninova, M.

AU - Kuusisto, J.

AU - Laaks, M.

AU - Lim, N.

AU - Lindblad, U.

AU - Lindgren, C.M.

AU - McCann, O.T.

AU - Mohlke, K.L.

AU - Morris, A.D.

AU - Naitza, S.

AU - Orrù, M.

AU - Palmer, C.N.A.

AU - Pouta, A.

AU - Randall, J.

AU - Rathmann, W.

AU - Saramies, J.

AU - Scheet, P.

AU - Scott, L.J.

AU - Scuteri, A.

AU - Sharp, S.

AU - Sijbrands, E.J.G.

AU - Smit, J.H.

AU - Song, K.

AU - Steinthorsdottir, V.

AU - Stringham, H.M.

AU - Tuomi, T.

AU - Tuomilehto, J.

AU - Uitterlinden, A.G.

AU - Voight, B.F.

AU - Waterworth, D.

AU - Wichmann, H.-E.

AU - Willemsen, G.

AU - Witteman, J.C.M.

AU - Yuan, X.

AU - Zha, J.H.

AU - Zeggini, E.

AU - Schlessinger, D.

AU - Sandhu, M.

AU - Boomsma, D.I.

AU - Uda, M.

AU - Spector, T.D.

AU - Penninx, B.W.J.H.

AU - Altshuler, D.

AU - Vollenweider, P.

AU - Jarvelin, M.-R.

AU - Lakatta, E.

AU - Waeber, G.

AU - Fox, C.S.

AU - Peltonen, L.

AU - Groop, L.C.

AU - Mooser, V.

AU - Cupples, L.A.

AU - Thorsteinsdottir, U.

AU - Abecasis, G.R.

PY - 2009

Y1 - 2009

N2 - To identify previously unknown genetic loci associated with fasting glucose concentrations, we examined the leading association signals in ten genome-wide association scans involving a total of 36,610 individuals of European descent. Variants in the gene encoding melatonin receptor 1B (MTNR1B) were consistently associated with fasting glucose across all ten studies. The strongest signal was observed at rs10830963, where each G allele (frequency 0.30 in HapMap CEU) was associated with an increase of 0.07 (95% CI = 0.06-0.08) mmol/l in fasting glucose levels (P = 3.2 × 10

AB - To identify previously unknown genetic loci associated with fasting glucose concentrations, we examined the leading association signals in ten genome-wide association scans involving a total of 36,610 individuals of European descent. Variants in the gene encoding melatonin receptor 1B (MTNR1B) were consistently associated with fasting glucose across all ten studies. The strongest signal was observed at rs10830963, where each G allele (frequency 0.30 in HapMap CEU) was associated with an increase of 0.07 (95% CI = 0.06-0.08) mmol/l in fasting glucose levels (P = 3.2 × 10

U2 - 10.1038/ng.290

DO - 10.1038/ng.290

M3 - Article

VL - 41

SP - 77

EP - 81

JO - Nature Genetics

JF - Nature Genetics

SN - 1061-4036

IS - 1

ER -

Prokopenko I, Langenberg C, Florez JC, Saxena R, Soranzo N, Thorleifsson G et al. Variants in MTNR1B influence fasting glucose levels. Nature Genetics. 2009;41(1):77-81. https://doi.org/10.1038/ng.290