Visibility of fiducial markers used for image-guided radiation therapy on optical coherence tomography for registration with CT: An esophageal phantom study

Pouya Jelvehgaran, Tanja Alderliesten, Jelmer J. A. Weda, Martijn de Bruin, Dirk J. Faber, Maarten C. C. M. Hulshof, Ton G. van Leeuwen, Marcel van Herk, Johannes F. de Boer

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

Optical coherence tomography (OCT) is of interest to visualize microscopic esophageal tumor extensions to improve tumor delineation for radiation therapy (RT) planning. Fiducial marker placement is a common method to ensure target localization during planning and treatment. Visualization of these fiducial markers on OCT permits integrating OCT and computed tomography (CT) images used for RT planning via image registration. We studied the visibility of 13 (eight types) commercially available solid and liquid fiducial markers in OCT images at different depths using dedicated esophageal phantoms and evaluated marker placement depth in clinical practice.
Original languageEnglish
Pages (from-to)6570-6582
Number of pages13
JournalMedical Physics
Volume44
Issue number12
DOIs
Publication statusPublished - Dec 2017

Funding

This work was supported by The Netherlands organization for health and development (ZonMw), Elekta Ltd, and Nine-Point Medical, Inc. The authors thank IBA Dosimetry, Naslund Medical AB, CIVCO Medical Solutions, QLRAD Inc., Nanovi, and Augmenix Inc. for providing the fiducial markers. The authors also thank Peng Jin for useful discussion.

FundersFunder number
Elekta Ltd
Netherlands organization for health and development
ZonMw

    Keywords

    • esophageal cancer
    • fiducial marker
    • image-guided radiation therapy (IGRT)
    • optical coherence tomography (OCT)
    • phantom

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